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Total 22100 results found since Jan 2013.

Scoping Review on Search Queries and Social Media for Disease Surveillance: A Chronology of Innovation
Conclusions: The use of search queries and social media for disease surveillance are relatively recent phenomena (first reported in 2006). Both the tools themselves and the methodologies for exploiting them are evolving over time. While their accuracy, speed, and cost compare favorably with existing surveillance systems, the primary challenge is to refine the data signal by reducing surrounding noise. Further developments in digital disease surveillance have the potential to improve sensitivity and specificity, passively through advances in machine learning and actively through engagement of users. Adoption, even as suppor...
Source: Journal of Medical Internet Research - July 18, 2013 Category: Journals (General) Authors: Theresa Marie BernardoAndrijana RajicIan YoungKatie RobiadekMai T PhamJulie A Funk Source Type: research

Burden of Disease and NIH Funding Priorities
Dr. Carrie Wolinetz is NIH’s Associate Director for Science Policy, and writes about biomedical research policy issues on her new blog, Under the Poliscope. Recently, many voices have asked how NIH considers public health needs when setting funding priorities. The quick answer is that public health needs are a critical factor in our decision making—in addition to scientific merit, portfolio balance, and budgetary considerations. But the question of how one measures public health need, as it turns out, isn’t as simple as you might think. Public health needs are not only reflected by how many people have a particular d...
Source: NIH Extramural Nexus - June 19, 2015 Category: Research Authors: Sally Rockey and Carrie Wolinetz Tags: Rock Talk disease burden Funding data RCDC RePORT Science policy Source Type: funding

A Prophylactic and Therapeutic for Preventing and Treating Tularemia by Rapid Activation of Host Cells and Antigen Recognition
The invention is a composition and method for prophylactic and therapeutic treatment of tularemia caused byFrancisella tularensis comprised of Cationic Liposome DNA Complexes (CLDC) complexed with noncoding DNA and membrane antigens isolated fromF. tularensis strain LVS (MPF).F. tularensis is category A pathogen (as designated by the NIH) that was previously weaponized by both the former Soviet Union and the United States of America and is currently a potential bioweapon and bioterrorism threat. Furthermore, tularemia is endemic to the U.S. (majority of the cases occurring in the Midwest) and Europe. The prophylactic and t...
Source: NIH OTT Licensing Opportunities - July 1, 2008 Category: Research Authors: ajoyprabhu3 Source Type: research

Method to Remove Mycoplasma Contamination from Virus Stocks
Mycoplasma are a form of bacteria that are commonly found as contaminants in cell cultures. They adversely affect cell line growth rates and viral vaccine production. Mycoplasma contamination is a challenge for the vaccine industry and virology researchers. Current commercial reagents or kits only temporarily inhibit the growth of mycoplasma, but cannot eliminate the contaminants.CDC has developed a method that can reliably eliminate mycoplasma from enveloped virus stock. This method allows for the removal of the mycoplasma without harming harvested virus. The harvested virus can then be transfected back into a clean cell ...
Source: NIH OTT Licensing Opportunities - June 13, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

NIAID OMNIBUS BROAD AGENCY ANNOUNCEMENT No. HHS-NIH-NIAID-BAA2018: Soliciting Proposals for Antimicrobial Products, Novel Vaccines and Technologies Against Category A, B, and C Agents, and Universal Influenza Vaccines
Notice NOT-AI-18-048 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 12, 2018 Category: Research Source Type: funding

Evolution of a Search: The Use of Dynamic Twitter Searches During Superstorm Sandy
Conclusion The most important lesson learned from Superstorm Sandy was the need for a dynamic and flexible monitoring process and strategy to understand and respond quickly to health needs in the areas impacted by Superstorm Sandy. Search strategies should change as frequently as the unfolding event. The inability to adapt to a changing situation ensures stale and stagnant terminology and search results. Twitter lists and Boolean searches should be used together to maximize situational awareness. The most important information comes from the impacted population, whether news, local government or local citizens. These are t...
Source: PLOS Currents Disasters - September 26, 2014 Category: Global & Universal Authors: Sara Harris Smith Source Type: research

Google’s Flu Project Shows the Failings of Big Data
MoreGoogle Will Start Encrypting Your SearchesScientists Can Now Predict the FluGoogle Will Pay You $15 for Each Business User You Get Hooked on GoogleBig data: as buzzwords go, it’s inescapable. Gigantic corporations like SAS and IBM tout their big data analytics, while experts promise that big data—our exponentially growing ability to collect and analyze information about anything at all—will transform everything from business to sports to cooking. Big data was—no surprise—one of the major themes coming out of this month’s SXSW Interactive conference. It’s inescapable. MoreTwitter Data Reveals W...
Source: TIME.com: Top Science and Health Stories - March 13, 2014 Category: Consumer Health News Authors: Bryan Walsh Tags: Uncategorized analysis big data CDC computer flu Google google flu trends illness influenza Model prediction Search SXSW Source Type: news

Application of Behavioral Theories to Disaster and Emergency Health Preparedness: A Systematic Review
CONCLUSIONS Based on the articles archived and selected, behavioral theories and models are applied to disasters and emergencies preparedness more commonly in developed countries (USA and Europe). In Asia, where the annual number of disasters events and victims exceed those in other continents, only 3 studies applying behavioral theories and models to disasters and emergencies were identifies. This identified a need for additional research to target the use of behavioral change theories in the Asian countries that bear the brunt of disasters and their consequences. This does not, however, mean that these theories have not ...
Source: PLOS Currents Disasters - July 1, 2015 Category: Global & Universal Authors: Luche Tadesse Ejeta Source Type: research

CDC Reports Flu Widespread, Google Search Trends Alarming
According to new surveillance statistics released on Friday from the Centers for Disease Control and Prevention (CDC), forty-seven states in the U.S. are now reporting widespread influenza activity [1]. The virus, which first appeared in the Southeast, has reached epidemic levels. Forty-seven states have reported widespread geographic influenza activity (i.e. incidence of flu) for the week between December 30, 2012 and January 5, 2013, and twenty-four states and New York City have reported high influenza-like illness (ILI) activity (i.e. the proportion of outpatient visits to healthcare providers for influenza-like illne...
Source: Highlight HEALTH - January 15, 2013 Category: Medical Scientists Authors: Walter Jessen, Ph.D. Source Type: blogs

Estimating Influenza Outbreaks Using Both Search Engine Query Data and Social Media Data in South Korea
Conclusions: These results demonstrate the feasibility of using search queries to enhance influenza surveillance in South Korea. In addition, an approach for query selection using social media data seems ideal for supporting influenza surveillance based on search query data.
Source: Journal of Medical Internet Research - July 3, 2016 Category: Journals (General) Authors: Hyekyung WooYoungtae ChoEunyoung ShimJong-Koo LeeChang-Gun LeeSeong Hwan Kim Source Type: research

Using web search queries to monitor influenza-like illness: an exploratory retrospective analysis, Netherlands, 2017/18 influenza season
This study demonstrates the feasibility of accurate, real-time ILI incidence predictions in the Netherlands using Google search query data.
Source: Eurosurveillance - May 28, 2020 Category: Infectious Diseases Authors: Paul P Schneider, Christel JAW van Gool, Peter Spreeuwenberg, Mari ëtte Hooiveld, Gé A Donker, David J Barnett and John Paget Source Type: research

In-silico search of virus-specific host microRNAs regulating avian influenza virus NS1 expression.
In this study, set of differentially expressed chicken miRNA identified by deep sequencing H5N1 infected and SPF chicken lung were computationally analyzed, to identify targets in the NS1 gene. 300 differentially expressed miRNAs were then analyzed individually for target sites in gi|147667147|gb|EF362422.1| influenza A virus (A/chicken/India/NIV33487/06(H5N1)) segment 8, complete sequence using RNAhybrid 2.2. The analysis yielded gga-miR-1658* as the potential miRNA which is targeting the NS1 gene of H5N1 genome. PMID: 25963812 [PubMed - as supplied by publisher]
Source: Theory in Biosciences - May 12, 2015 Category: Biology Authors: Muhasin Asaf VN, Kumar A, Raut AA, Bhatia S, Mishra A Tags: Theory Biosci Source Type: research

Methods Using Social Media and Search Queries to Predict Infectious Disease Outbreaks.
Conclusions: This prediction method could be the core engine for implementing a (near-) real-time digital surveillance system. A digital surveillance system that uses Internet resources has enormous potential to monitor disease outbreaks in the early phase. PMID: 29181246 [PubMed]
Source: Healthcare Informatics Research - November 29, 2017 Category: Information Technology Tags: Healthc Inform Res Source Type: research

Scaffold morphing of arbidol (umifenovir) in search of multi-targeting therapy halting the interaction of SARS-CoV-2 with ACE2 and other proteases involved in COVID-19.
Abstract The rapid emergence of a novel coronavirus, SARS-coronavirus 2 (SARS-CoV-2), originated from Wuhan, China, imposed a global health emergency. Angiotensin-converting enzyme 2 (ACE2) receptor serves as an entry point for this deadly virus while the proteases like furin, transmembrane protease serine 2 (TMPRSS2) and 3 chymotrypsin-like protease (3CLpro) are involved in the further processing and replication of SARS-CoV-2. The interaction of SP with ACE2 and these proteases results in the SARS-CoV-2 invasion and fast epidemic spread. The small molecular inhibitors are reported to limit the interaction of SP w...
Source: Virus Research - August 27, 2020 Category: Virology Authors: Choudhary S, Silakari O Tags: Virus Res Source Type: research