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Infectious Disease: Influenza
Therapy: Stem Cell Therapy
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Total 81 results found since Jan 2013.
Multiplex PCR assay to detect nasopharyngeal viruses in immunocompromised patients with acute respiratory failure
Chest. 2023 Aug 9:S0012-3692(23)05262-5. doi: 10.1016/j.chest.2023.07.4222. Online ahead of print.ABSTRACTBACKGROUND: In immunocompromised patients with acute respiratory failure (ARF), the clinical significance of respiratory virus detection in the nasopharynx remains uncertain.RESEARCH QUESTION: Is viral detection in nasopharyngeal swabs associated with causes and outcomes of ARF in immunocompromised patients?STUDY DESIGN AND METHODS: Preplanned post hoc analysis of a randomized controlled trial enrolling immunocompromised patients admitted to 32 ICUs for ARF between May 2016, and December 2017. Nasopharyngeal swabs samp...
Source: Chest - August 11, 2023 Category: Respiratory Medicine Authors: Alexis Maillard J érôme Le Goff Mariame Barry Virginie Lemiale S éverine Mercier-Delarue Alexandre Demoule Linda Feghoul Samir Jaber Kada Klouche Achille Kouatchet Laurent Argaud Francois Barbier Naike Big é Anne-Sophie Moreau Emmanuel Canet Fr édér Source Type: research
Human brain microphysiological systems in the study of neuroinfectious disorders
Exp Neurol. 2023 Apr 13:114409. doi: 10.1016/j.expneurol.2023.114409. Online ahead of print.ABSTRACTMicrophysiological systems (MPS) are 2D or 3D multicellular constructs able to mimic tissue microenvironments. The latest models encompass a range of techniques, including co-culturing of various cell types, utilization of scaffolds and extracellular matrix materials, perfusion systems, 3D culture methods, 3D bioprinting, organ-on-a-chip technology, and examination of tissue structures. Several human brain 3D cultures or brain MPS (BMPS) have emerged in the last decade. These organoids or spheroids are 3D culture systems der...
Source: Experimental Neurology - April 15, 2023 Category: Neurology Authors: Paula Barreras David Pamies Thomas Hartung Carlos A Pardo Source Type: research
Prognostic factors for the development of lower respiratory tract infection after influenza virus infection in allogeneic hematopoietic stem cell transplantation recipients: A KSGCT Multicenter Analysis
CONCLUSIONS: To reduce the risk of LRTI development after IVI, early NAI therapy should be considered in allo-HSCT recipients, especially with older patients and those with chronic graft-versus-host disease.PMID:37001798 | DOI:10.1016/j.ijid.2023.03.045
Source: Cancer Control - March 31, 2023 Category: Cancer & Oncology Authors: Kaito Harada Makoto Onizuka Takehiko Mori Hiroaki Shimizu Sachiko Seo Nobuyuki Aotsuka Yusuke Takeda Noritaka Sekiya Machiko Kusuda Shinichiro Fujihara Sawako Shiraiwa Katsuhiro Shono Naoki Shingai Heiwa Kanamori Mamiko Momoki Satoru Takada Junichi Mukae Source Type: research
Analysis of Influenza A virus infection in human induced pluripotent stem cells (hiPSCs) and their derivatives
Virus Res. 2022 Nov 19:199009. doi: 10.1016/j.virusres.2022.199009. Online ahead of print.ABSTRACTInfluenza A virus (IAV) infection in pregnant women is a major public health concern. However, the effect of IAV infection on human embryogenesis is still unclear. Here we show that human induced pluripotent stem cells (hiPSCs) and hiPSC-derived ectodermal, mesodermal and endodermal cells are susceptible to IAV infection. These cell types stained positive for α2,6-linked sialic acid, the receptor for IAV infection expressed on the cell surface. While hiPSCs produced high viral titers for up to 7 days with increasing infected ...
Source: Cell Research - November 22, 2022 Category: Cytology Authors: Kanyarat Ruangrung Warunya Chakritbudsabong Songkran Thongon Sasitorn Rungarunlert Methichit Wattanapanitch Chompunuch Boonarkart Ornpreya Suptawiwat Naraporn Sirinonthanawech Duncan Richard Smith Prasert Auewarakul Source Type: research
Valeridoids G - Q, Eleven seco-Iridoids from Valeriana jatamansi and Their Bioactivites
Chem Biodivers. 2022 Aug 23:e202200609. doi: 10.1002/cbdv.202200609. Online ahead of print.ABSTRACTEleven new seco-iridoids, valeridoids G-Q (1-6 and 8-12), along with four known products, 9-epi-valtral C (7), desacylbaldrinal (13), 11-methoxyviburtinal (14) and baldrinal (15), were obtained from Valeriana jatamansi. Among them, the new compounds were identified by their NMR, HR-ESI-MS spectroscopic data and ECD calculation. Moreover, valeridoid N and O were a pair of C3 epimers, whose ether bonds between C-1 and C-3 opened, and new ether bonds formed between C-3 and C-6. Valeridoid Q belonged to the C-1 degradation of sec...
Source: Chemistry and Biodiversity - August 23, 2022 Category: Biochemistry Authors: Li-Qiu Quan Yun Wang Jian-Xian Tang Yan Zhou Cai-Cen Liao Dan Liu Xu-Dong Zhao Rong-Tao Li Hong-Mei Li Source Type: research
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages
CONCLUSIONS: Collectively, our findings indicate that severe lung injury in COVID-19 likely results from a macrophage triggered immune activation rather than direct viral damage of the alveolar compartment.PMID:35728978 | DOI:10.1183/13993003.02725-2021
Source: Respiratory Care - June 21, 2022 Category: Respiratory Medicine Authors: Katja H önzke Benedikt Obermayer Christin Mache Diana Fathykova Mirjana Kessler Simon D ökel Emanuel Wyler Morris Baumgardt Anna L öwa Karen Hoffmann Patrick Graff Jessica Schulze Maren Mieth Katharina Hellwig Zeynep Demir Barbara Biere Linda Brunotte Source Type: research
CD34 protein is expressed in murine, canine, and porcine lungs
Can J Vet Res. 2021 Jul;85(3):161-169.ABSTRACTThe cell surface protein CD34 is expressed in various human tissues and cells, including hematopoietic stem cells, vascular endothelial cells, mucosal dendritic cells, mast cells, eosinophils, microglia, fibrocytes, muscle satellite cells, and platelets. There is a lack of data on the expression of CD34 in canine and porcine tissues. Therefore, we designed a series of immunoblotting, immunohistochemistry, and immunofluorescence experiments to observe CD34 expression in murine, canine, and porcine lungs. We used a rabbit antibody (clone EP373Y) to target the conserved human CD34...
Source: Canadian Journal of Veterinary Research - July 12, 2021 Category: Veterinary Research Authors: Gurpreet K Aulakh Sushmita Maltare Le Nguyen Phuong Khanh Baljit Singh Source Type: research
