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Infectious Disease: Influenza
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Total 16141 results found since Jan 2013.
Impact of SARS-CoV-2-Related Hygiene Measures on Community-Acquired Respiratory Virus Infections in Lung Transplant Recipients in Switzerland
Conclusions: We observed a significant decline in CARV infections in the Swiss lung transplant cohort during the first year of the COVID-19 pandemic. These results suggest a relevant impact of hygiene measures when implemented in the population due to the COVID-19 pandemic on the incidence of CARV infections.PMID:37629763 | PMC:PMC10456728 | DOI:10.3390/medicina59081473
Source: Medicina (Kaunas) - August 26, 2023 Category: Universities & Medical Training Authors: Isabelle Baumann Ren é Hage Paola Gasche-Soccal John-David Aubert Mac é M Schuurmans None The Swiss Transplant Cohort Study Source Type: research
Age-specific severity of severe acute respiratory syndrome coronavirus 2 in February 2020 to June 2021 in the Netherlands
CONCLUSION: Whereas the increase in severity of Severe Acute Respiratory Syndrome Coronavirus 2 with age remained stable, the risk of death upon infection decreased over time. A significant drop in risk of death among elderly coincided with the introduction of COVID-19 vaccination.PMID:37621921 | PMC:PMC10444602 | DOI:10.1111/irv.13174
Source: Respiratory Care - August 25, 2023 Category: Respiratory Medicine Authors: Pieter T de Boer Jan van de Kassteele Eric R A Vos Liselotte van Asten Dave A Dongelmans Arianne B van Gageldonk-Lafeber Gerco den Hartog Agnetha Hofhuis Fiona van der Klis Dylan W de Lange Lenny Stoeldraijer RIVM COVID ‐19 epidemiology and surveillance Source Type: research
Discovery of a potent inhibitor targeting the cap-binding domain of the PB2 subunit of influenza RNA-dependent RNA polymerase
Biochem Biophys Res Commun. 2023 Aug 12;678:97-101. doi: 10.1016/j.bbrc.2023.08.027. Online ahead of print.ABSTRACTInfluenza pandemics have emerged as a significant global public health and security concern. PB2, a crucial subunit of the influenza RNA-dependent RNA polymerase (RdRP), has been identified as a promising target for influenza treatment. We herein report the discovery of a potent novel PB2 inhibitor, 7-51A, with a KD value of 1.64 nM as determined by ITC. The high activity of 7-51A was elucidated by the co-crystal structure of the PB2-7-51A complex, and comparative analysis revealed unique interactions that had...
Source: Biochemical and Biophysical Research communications - August 25, 2023 Category: Biochemistry Authors: Weining Sun Ziling Zhang Mingxin Chen Xinlei Liu Yifei Wang Shaohua Yao Linli Li Source Type: research
Age-specific severity of severe acute respiratory syndrome coronavirus 2 in February 2020 to June 2021 in the Netherlands
CONCLUSION: Whereas the increase in severity of Severe Acute Respiratory Syndrome Coronavirus 2 with age remained stable, the risk of death upon infection decreased over time. A significant drop in risk of death among elderly coincided with the introduction of COVID-19 vaccination.PMID:37621921 | PMC:PMC10444602 | DOI:10.1111/irv.13174
Source: Respiratory Care - August 25, 2023 Category: Respiratory Medicine Authors: Pieter T de Boer Jan van de Kassteele Eric R A Vos Liselotte van Asten Dave A Dongelmans Arianne B van Gageldonk-Lafeber Gerco den Hartog Agnetha Hofhuis Fiona van der Klis Dylan W de Lange Lenny Stoeldraijer RIVM COVID ‐19 epidemiology and surveillance Source Type: research
< i > TFOFinder < /i > : Python program for identifying purine-only double-stranded stretches in the predicted secondary structure(s) of RNA targets
by Atara Neugroschl, Irina E. Catrina
Nucleic acid probes are valuable tools in biology and chemistry and are indispensable for PCR amplification of DNA, RNA quantification and visualization, and downregulation of gene expression. Recently, triplex-forming oligonucleotides (TFO) have received increased attention due to their improved selectivity and sensitivity in recognizing purine-rich double-stranded RNA regions at physiological pH by incorporating backbone and base modifications. For example, triplex-forming peptide nucleic acid (PNA) oligomers have been used for imaging a structured RNA in cells and inhibiting influe...
Source: PLoS Computational Biology - August 25, 2023 Category: Biology Authors: Atara Neugroschl Source Type: research
Limited Outbreak of Highly Pathogenic Influenza A(H5N1) in Herring Gull Colony, Canada, 2022
Emerg Infect Dis. 2023 Aug 24;29(10). doi: 10.3201/eid2910.230536. Online ahead of print.ABSTRACTIn summer 2022, highly pathogenic influenza A(H5N1) virus reached the herring gull (Larus argentatus subspecies smithsonianus) breeding colony on Kent Island, New Brunswick, Canada. Real-time monitoring revealed a self-limiting outbreak with low mortality. Proactive seabird surveillance is crucial for monitoring such limited outbreaks, protecting seabirds, and tracing zoonotic transmission routes.PMID:37619593 | DOI:10.3201/eid2910.230536
Source: Emerging Infectious Diseases - August 24, 2023 Category: Infectious Diseases Authors: Liam U Taylor Robert A Ronconi Hayley A Spina Megan E B Jones C Brandon Ogbunugafor Andrea J Ayala Source Type: research
Characterization of antibodies to SARS-CoV-2 in lyophilized plasma prepared with amotosalen-UVA pathogen reduction
CONCLUSIONS: The antibody activity in pooled pathogen-reduced lyophilized CCPs demonstrated minimal impact due to pathogen reduction treatment and lyophilization.PMID:37615329 | DOI:10.1111/trf.17506
Source: Transfusion - August 24, 2023 Category: Hematology Authors: Christophe Martinaud Anil Bagri Cheng-Ting Tsai Rafael R de Assis Michelle Gatmaitan Peter V Robinson David Seftel Saahir Khan Philip L Felgner Laurence M Corash Source Type: research
Interspecies Transmission of Swine Influenza A Viruses and Human Seasonal Vaccine-Mediated Protection Investigated in Ferret Model
Emerg Infect Dis. 2023 Sep;29(9):1798-1807. doi: 10.3201/eid2909.230066.ABSTRACTWe investigated the infection dynamics of 2 influenza A(H1N1) virus isolates from the swine 1A.3.3.2 (pandemic 2009) and 1C (Eurasian, avian-like) lineages. The 1C-lineage virus, A/Pavia/65/2016, although phylogenetically related to swine-origin viruses, was isolated from a human clinical case. This strain infected ferrets, a human influenza model species, and could be transmitted by direct contact and, less efficiently, by airborne exposure. Infecting ferrets and pigs (the natural host) resulted in mild or inapparent clinical signs comparable ...
Source: Emerging Infectious Diseases - August 23, 2023 Category: Infectious Diseases Authors: Pauline M van Diemen Alexander M P Byrne Andrew M Ramsay Samantha Watson Alejandro Nunez Ana V Moreno Chiara Chiapponi Emanuela Foni Ian H Brown Sharon M Brookes Helen E Everett Source Type: research
Shifting Patterns of Influenza Circulation during the COVID-19 Pandemic, Senegal
Emerg Infect Dis. 2023 Sep;29(9):1808-1817. doi: 10.3201/eid2909.230307.ABSTRACTHistorically low levels of seasonal influenza circulation were reported during the first years of the COVID-19 pandemic and were mainly attributed to implementation of nonpharmaceutical interventions. In tropical regions, influenza's seasonality differs largely, and data on this topic are scarce. We analyzed data from Senegal's sentinel syndromic surveillance network before and after the start of the COVID-19 pandemic to assess changes in influenza circulation. We found that influenza shows year-round circulation in Senegal and has 2 distinct e...
Source: Emerging Infectious Diseases - August 23, 2023 Category: Infectious Diseases Authors: Alexandre Lampros Cheikh Talla Maryam Diarra Billo Tall Samba Sagne Mamadou Korka Diallo Boly Diop Ibrahim Oumar Ndongo Dia Amadou Alpha Sall Mamadou Aliou Barry Cheikh Loucoubar Source Type: research
Cell-Cell Fusion Assays to Study Henipavirus Entry and Evaluate Therapeutics
Methods Mol Biol. 2023;2682:59-69. doi: 10.1007/978-1-0716-3283-3_4.ABSTRACTHenipaviruses include the deadly zoonotic Nipah (NiV) and Hendra (HeV) paramyxoviruses, which have caused recurring outbreaks in human populations. A hallmark of henipavirus infection is the induction of cell-cell fusion (syncytia), caused by the expression of the attachment (G) and fusion (F) glycoproteins on the surface of infected cells. The interactions of G and F with each other and with receptors on cellular plasma membranes drive both viral entry and syncytia formation and are thus of great interest. While F shares structural and functional ...
Source: Mol Biol Cell - August 23, 2023 Category: Molecular Biology Authors: I Abrrey Monreal Hector C Aguilar Source Type: research
