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Risk factors and prognosis for latent tuberculosis infection in dialysis patients: A retrospective cohort study at a single tertiary care center
CONCLUSIONS: Prior TB history, tobacco use, and the elderly can be used to select cost-effective LTBI screening target groups in dialysis patients. LTBI is not only closely related to active TB but also an independent risk factor for higher incidence of MACE in dialysis population.PMID:36823755 | DOI:10.1111/sdi.13150
Source: Seminars in Dialysis - February 24, 2023 Category: Urology & Nephrology Authors: Yun Xia Qiuxia Fan Jieyun Zhang Li Jiang Xiaoyan Huang Zuying Xiong Zibo Xiong Source Type: research

Update of the mechanism and characteristics of tuberculosis in chronic kidney disease : Review article
Wien Klin Wochenschr. 2022 Mar 7. doi: 10.1007/s00508-022-02009-y. Online ahead of print.ABSTRACTThe risk of tuberculosis (TB) is significantly increased in patients with chronic kidney disease (CKD), which is closely related to hyperparathyroidism, malnutrition and oxidative stress as well as immune deficiency in patients with end-stage renal disease (ESRD). Vitamin D deficiency and gender bias are independent risk factors. In the TB screening and diagnosis test of CKD, interferon-gamma release assays (IGRA), including T‑SPOT.TB test (T-SPOT) and QuantiFERON-TB Gold In-Tube (QFT-GIT) have been available. Many studies ha...
Source: Wiener Klinische Wochenschrift - March 7, 2022 Category: General Medicine Authors: Xuehan Zhang Pingshan Chen Gaosi Xu Source Type: research

Trends of treated hepatitis B, hepatitis C, and tuberculosis infection in long-term hemodialysis patients in Taiwan: A nationwide survey in 2010-2018
CONCLUSION: The increasing yearly trend of treated HBV and HCV and a stable trend of treated TB provide evidence for further infection control management and risk population identification of the HD population.PMID:34996670 | DOI:10.1016/j.jfma.2021.12.019
Source: J Formos Med Assoc - January 8, 2022 Category: General Medicine Authors: Jia-Jung Lee Jer-Ming Chang Lii-Jia Yang Chih-Cheng Hsu Ming-Huang Lin Ming-Yen Lin Source Type: research

Lactic acidosis associated with standard dose linezolid in a kidney recipient with impaired renal function
We describe an adult male who underwent kidney transplantation with stably impaired renal function, severe dyspnea, and abdominal discomfort. He received a standard oral dose of LZD (600 mg twice daily) and azithromycin for three weeks with a reduced immunosuppressant dose due to pulmonary non-tuberculosis mycobacterial infection. He was alert and afebrile, with a blood pressure of 140/60 mmHg. Pertinent laboratory data showed: pH 7.12, PaCO2 13.6 mmHg; HCO3- 4.3 mmol/L and serum lactate 18.4 mmol/L. His trough serum LZD concentration reached toxic levels (21.4 μg/mL). With hemodialysis, his clinical symptoms improved, wi...
Source: Braz J Infect Dis - December 23, 2021 Category: Infectious Diseases Authors: Chien-Chou Chen Wei-Ting Liu Shih-Hua Lin Source Type: research

Tuberculosis treatment delay and nosocomial exposure remain important risks for patients undergoing regular hemodialysis
CONCLUSION: Nosocomial exposure attributed to delay in the diagnosis of index pulmonary TB is important in TB transmission among patients undergoing regular hemodialysis. Additional studies investigating how TB can be diagnosed and treated early are warranted.SUMMARY AT A GLANCE: Our study revealed that nosocomial exposure, attributed to delay in pulmonary TB diagnosis, is important in TB transmission among patients undergoing regular hemodialysis. Strategies to diagnose and treat TB early are crucial to infection control, and they warrant further investigations.PMID:34535393 | DOI:10.1016/j.jmii.2021.08.011
Source: Journal of Microbiology, Immunology, and Infection - September 18, 2021 Category: Microbiology Authors: Michael Lu Yuh-Mou Sue Han-Lin Hsu Jun-Fu Zhang Yi-Jun Liu Yu-Chun Yen Tzu-Yun Yu Ming-Chih Yu Chih-Hsin Lee Source Type: research

Epidemiology of Nontuberculous Mycobacterial Infection in Tuberculosis Suspects
Am J Trop Med Hyg. 2021 Aug 23:tpmd210095. doi: 10.4269/ajtmh.21-0095. Online ahead of print.ABSTRACTNontuberculosis mycobacteria (NTM) are opportunistic pathogens that cause a wide range of illnesses. Here, the species distribution and prevalence of NTM infections in tuberculosis suspects was analyzed. A total of 7,073 specimens from pulmonary and extrapulmonary sites were analyzed, and 709 (10%) were found to be culture positive for mycobacteria. Of these, 85.2% were identified as Mycobacterium tuberculosis complex and 14.8% as NTM (65.7% rapid growers and 34.3% slow growers). Speciation of the NTM isolates (n = 69) iden...
Source: Am J Trop Med Hyg - August 23, 2021 Category: Infectious Diseases Authors: Parasmal Suresh Anil Kumar Raja Biswas Divya Vijayakumar Swathy Thulasidharan Gopikrishnan Anjaneyan Akhilesh Kunoor Lalitha Biswas Source Type: research

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