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Infectious Disease: COVID-19
Management: Hospitals

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Total 425 results found since Jan 2013.

STudy of Alteplase for Respiratory failure in SARS-Cov2 COVID-19 (STARS): A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized, Controlled Trial
Chest. 2021 Sep 27:S0012-3692(21)04063-0. doi: 10.1016/j.chest.2021.09.024. Online ahead of print.ABSTRACTBACKGROUND: Pulmonary vascular microthrombi are a proposed mechanism of COVID19 respiratory failure. We hypothesized that early administration of tissue-plasminogen activator(tPA) followed by therapeutic heparin would improve pulmonary function in these patients.RESEARCH QUESTION: Does tPA improve pulmonary function in severe COVID-19 respiratory failure, and is it safe?STUDY DESIGN AND METHODS: Adults with COVID-19-induced respiratory failure were randomized May14,2020-March 3,2021 in two phases: Phase-1(n=36): contro...
Source: Chest - September 30, 2021 Category: Respiratory Medicine Authors: Christopher D Barrett Hunter B Moore Ernest E Moore D Janice Wang Negin Hajizadeh Walter L Biffl Lawrence Lottenberg Purvesh R Patel Michael S Truitt Robert McIntyre Todd M Bull Lee Anne Ammons Arsen Ghasabyan James Chandler Ivor Douglas Eric Schmidt Pete Source Type: research

Bringing WISDOM to Breast Cancer Care
Dr. Laura Esserman answers the door of her bright yellow Victorian home in San Francisco’s Ashbury neighborhood with a phone at her ear. She’s wrapping up one of several meetings that day with her research team at University of California, San Francisco, where she heads the Carol Franc Buck Breast Care Center. She motions me in and reseats herself at a makeshift home office desk in her living room, sandwiched between a grand piano and set of enormous windows overlooking her front yard’s flower garden. It’s her remote base of operations when she’s not seeing patients or operating at the hospita...
Source: TIME: Health - October 22, 2021 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Source Type: news

Functional dependency and COVID-19 in elderly patients with mild to moderate disease. Experience of tertiary geriatric hospital
Exp Gerontol. 2021 Nov 3:111620. doi: 10.1016/j.exger.2021.111620. Online ahead of print.ABSTRACTClinical course of COVID-19 may be associated with functional dependency of geriatric patients. Data from the records of patients admitted to the COVID-19 Geriatric Unit were gathered during three months, including background, clinical aspects, time to resolution of infection and functional status. Functionally dependent patients had higher rates of diabetes (p = 0.03) and stroke (p = 0.004), as well as longer time to resolution of infection (p < 0.001), but less respiratory COVID-19 symptoms (p = 0.007), compared to indepen...
Source: Experimental Gerontology - November 7, 2021 Category: Geriatrics Authors: Lubart Emily Gal Gilad Mizrahi Eliyahu Haim Goltsman Galina Source Type: research

Thrombogenicity markers for early diagnosis and prognosis in COVID-19: a change from the current paradigm?
Standard biomarkers have been widely used for COVID-19 diagnosis and prognosis. We hypothesize that thrombogenicity metrics measured by thromboelastography will provide better diagnostic and prognostic utility versus standard biomarkers in COVID-19 positive patients. In this observational prospective study, we included 119 hospitalized COVID-19 positive patients and 15 COVID-19 negative patients. On admission, we measured standard biomarkers and thrombogenicity using a novel thromboelastography assay (TEG-6s). In-hospital all-cause death and thrombotic occurrences (thromboembolism, myocardial infarction and stroke) were re...
Source: Blood Coagulation and Fibrinolysis - November 19, 2021 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Late Breaking Abstract - Management of COVID-19 pneumonia in an enhanced respiratory step down unit: a novel approach
Throughout the COVID-19 pandemic, patients have received escalated care on specialist respiratory wards outside of intensive care units (ICU) in various forms. We performed this study to review the effectiveness of an enhanced respiratory step-down unit (ECU) during the COVID-19 pandemic at Warrington and Halton Teaching Hospitals NHS Foundation Trust.This was a retrospective observational study of patients admitted to the ECU from ICU between April 2020 and January 2021. Data collected included demographics, treatments given and outcomes.We accepted patients to the ECU following level 2-3 care but still requiring speciali...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Agrawal, V. A., Ravi, A., Prior, A., Proctor, J., Baluwala, A. H. Tags: Respiratory infections and bronchiectasis Source Type: research

Thromboembolic events in COVID-19 patients : A Tunisian case series study
Coronavirus disease 2019 (COVID-19) can lead to systemic coagulation activation and thrombotic complications(TC), which may lead to fatal outcomes if not diagnosed and managed appropriately.We aimed to report the incidence and characteristics of venous and arterial thrombotic complications(TC) in hospitalized patients with COVID-19 and to investigate the predictive factors of their occurrence.A retrospective study including 200 patients with COVID-19 confirmed by a reverse transcription polymerase chain reaction test, admitted between March 2020 and January 2021 in the pulmonary departement B at Abderrahman Mami Hospi...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Louhaichi, S., Ferchichi, M., Khalfallah, I., Belkhir, S., Boubaker, N., Ammar, J., Hamdi, B., Hamzaoui, A. Tags: Respiratory infections and bronchiectasis Source Type: research

Real-time reviews of research findings will help policymakers address global crises such as COVID-19
Real-time reviews of research findings could help policymakers address global crises such as COVID-19, saysthis   articlepublished   inNature. Living evidence was first developed by Cochrane and an important recommendation for future health emergencies that came out of the recent Cochrane Convenes meetings. According to scientists writing in the peer-reviewed journal  Nature, policy missteps will continue to overshadow the global response to COVID-19 because policymakers are overwhelmed with rapidly shifting research evidence. Faced with new challenges such as the Omicron variant, decision-makers can ’t keep up wi...
Source: Cochrane News and Events - December 15, 2021 Category: Information Technology Authors: Lydia Parsonson Source Type: news

EP40 Teleproctoring in neurointerventionism
6 cases of neurovascular treatment with remote assistance are presented. various techniques (zoom, smart glasses and hospital internal system) 2 aneurysm treatments with flow diversion are presented. 1 case with web device. and 3 cases of stroke.All cases occurred during the covid 19 pandemic.Multiple tests were carried out during the simulation courses. Evaluating communication in real time. mastery of the images and mastery of the software.ReferenceBechstein M, et al. Interhospital teleproctoring of endovascular intracranial aneurysm treatment using a dedicated live-streaming technology: first experiences during the COVI...
Source: Journal of NeuroInterventional Surgery - August 24, 2021 Category: Neurosurgery Authors: Pabon, B., Torres, V., Patino, M., Serna, N., Vargas, O., Estrada, C., Pelaez, J., Mejia, J. Tags: Logistics Source Type: research

E-044 Stenting of intracranial stenosis through an angioplasty balloon catheter - A case series
ConclusionDeploying self-expanding stents through an angioplasty balloon catheter is feasible, safe, and can greatly simplify the procedure. The Neuroform Atlas stent is strong enough to prevent immediate recoil of intracranial stenosis after angioplasty.Disclosures A. Takayanagi: None. J. Fields: None. K. Chao: None. D. Rex: None. P. Cheng: None. L. Feng: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Takayanagi, A., Fields, J., Chao, K., Rex, D., Cheng, P., Feng, L. Tags: Electronic poster abstracts Source Type: research

Mini-Review on SARS-CoV-2 Infection and Neurological Manifestations: A Perspective
CNS Neurol Disord Drug Targets. 2021 Jul 6. doi: 10.2174/1871527320666210706103422. Online ahead of print.ABSTRACTThe coronavirus, also known as SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-19), with its rapid rate of transmission, has progressed with a great impact on respiratory function and mortality worldwide. The nasal cavity is the promising gateway of SARS-CoV-2 to reach the brain via systemic circulatory distribution. Recent reports have revealed that the loss of involuntary process of breathing control into the brainstem that results in death is a signal of neurological involvement. Early neurologica...
Source: CNS and Neurological Disorders Drug Targets - December 30, 2021 Category: Drugs & Pharmacology Authors: Vishal Chavda Arif Tasleem Jan Dhananjay Yadav Source Type: research

Relation of interleukin-6 levels in COVID-19 patients with major adverse cardiac events
Proc (Bayl Univ Med Cent). 2021 Sep 1;35(1):6-9. doi: 10.1080/08998280.2021.1961571. eCollection 2022.ABSTRACTElevated interleukin-6 (IL-6) levels may correlate with disease severity in COVID-19. We analyzed whether there was an association between elevated IL-6 levels and major adverse cardiac events (MACE) and/or mortality in COVID-19 patients. A retrospective chart review was performed on COVID-19 patients among four hospitals in one health system from March to May 2020, extracting information on baseline characteristics, MACE (i.e., myocardial infarction, stroke, deep venous thrombosis/pulmonary embolism, or shock requ...
Source: Baylor University Medical Center Proceedings - December 30, 2021 Category: Universities & Medical Training Authors: Nicholas Nguyen Hao Nguyen Chijioke Ukoha Lawrence Hoang Chirag Patel Farukh G Ikram Priyanka Acharya Anmol Dhillon Manavjot Sidhu Source Type: research

Mini-Review on SARS-CoV-2 Infection and Neurological Manifestations: A Perspective
CNS Neurol Disord Drug Targets. 2021 Jul 6. doi: 10.2174/1871527320666210706103422. Online ahead of print.ABSTRACTThe coronavirus, also known as SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-19), with its rapid rate of transmission, has progressed with a great impact on respiratory function and mortality worldwide. The nasal cavity is the promising gateway of SARS-CoV-2 to reach the brain via systemic circulatory distribution. Recent reports have revealed that the loss of involuntary process of breathing control into the brainstem that results in death is a signal of neurological involvement. Early neurologica...
Source: CNS and Neurological Disorders Drug Targets - December 30, 2021 Category: Drugs & Pharmacology Authors: Vishal Chavda Arif Tasleem Jan Dhananjay Yadav Source Type: research

Relation of interleukin-6 levels in COVID-19 patients with major adverse cardiac events
Proc (Bayl Univ Med Cent). 2021 Sep 1;35(1):6-9. doi: 10.1080/08998280.2021.1961571. eCollection 2022.ABSTRACTElevated interleukin-6 (IL-6) levels may correlate with disease severity in COVID-19. We analyzed whether there was an association between elevated IL-6 levels and major adverse cardiac events (MACE) and/or mortality in COVID-19 patients. A retrospective chart review was performed on COVID-19 patients among four hospitals in one health system from March to May 2020, extracting information on baseline characteristics, MACE (i.e., myocardial infarction, stroke, deep venous thrombosis/pulmonary embolism, or shock requ...
Source: Baylor University Medical Center Proceedings - December 30, 2021 Category: Universities & Medical Training Authors: Nicholas Nguyen Hao Nguyen Chijioke Ukoha Lawrence Hoang Chirag Patel Farukh G Ikram Priyanka Acharya Anmol Dhillon Manavjot Sidhu Source Type: research

These Charts Show That COVID-19 is Still the Pandemic of the Unvaccinated
Over the summer of 2021, as the Delta variant swept the nation, Americans’ experience with COVID-19 bifurcated. Among vaccinated people, cases were low and deaths were rare; at the same time, people with no immunity were getting sick and dying at alarming rates. COVID-19 became the pandemic of the unvaccinated. Then in December, Omicron showed up. Cases have surged in recent weeks, blowing past records set during the Delta wave. Driving this trend is Omicron’s extremely high transmissibility, compounded by waning immunity among vaccinated people who are experiencing symptomatic breakthrough infections. With cas...
Source: TIME: Health - January 12, 2022 Category: Consumer Health News Authors: Emily Barone Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news