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Infectious Disease: SARS
Therapy: Stem Cell Therapy

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Total 448 results found since Jan 2013.

The Pathogenesis of COVID-19-Related Taste Disorder and Treatments
J Dent Res. 2023 Sep 20:220345231182926. doi: 10.1177/00220345231182926. Online ahead of print.ABSTRACTCOVID-19, mainly manifested as acute respiratory distress syndrome, has afflicted millions of people worldwide since 2019. Taste dysfunction is a common early-stage symptom of COVID-19 infection that burdens patients for weeks or even permanently in some cases. Owing to its subjectivity and complexity, the mechanism of taste disorder is poorly studied. Previous studies have reported that the COVID-19 entry receptors are highly expressed in taste buds, thereby intensifying the cytocidal effect. Taste receptor cells are vul...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: J Wang R Liu H Ma W Zhang Source Type: research

Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

SARS-CoV-2 viral genes Nsp6, Nsp8, and M compromise cellular ATP levels to impair survival and function of human pluripotent stem cell-derived cardiomyocytes
CONCLUSION: Overall, our findings uncover the extensive damaging effects of Nsp6, Nsp8, and M on hPSC-CMs, underlining the crucial role of ATP homeostasis in CM death and functional abnormalities induced by these SARS-CoV-2 genes, and reveal the potential therapeutic strategies to alleviate these detrimental effects with FDA-approved drugs.PMID:37705046 | DOI:10.1186/s13287-023-03485-3
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Juli Liu Shiyong Wu Yucheng Zhang Cheng Wang Sheng Liu Jun Wan Lei Yang Source Type: research

Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation
This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).PMID:37699145 | DOI:10.1165/rcmb.2023-0104OC
Source: Am J Respir Cell Mol... - September 12, 2023 Category: Respiratory Medicine Authors: Kamakshi Bankoti Wei Wang Gaurang M Amonkar Linjie Xiong Jessica E Shui Caiqi Zhao Eric Van Chimwemwe Mwase Jin-Ah Park Hongmei Mou Yinshan Fang Jianwen Que Yan Bai Paul H Lerou Xingbin Ai Source Type: research

More than Meets the Eye: Orbital Swelling in an Adolescent with Sickle Cell Disease
Int J Hematol Oncol Stem Cell Res. 2023 Jan 1;17(1):56-62. doi: 10.18502/ijhoscr.v17i1.11714.ABSTRACTPeriorbital swelling is a clinical presentation with a broad differential and potentially deleterious consequence. Causes range from benign, including allergic reaction, to vision- and life-threatening, including orbital cellulitis and orbital infarction. The recent climate of SARS-CoV-2 has further complicated this differential, as the virus poses broad clinical presentations with new manifestations reported frequently. Rapid identification of the underlying etiology is crucial, as treatment approaches diverge greatly. Her...
Source: Cell Research - August 28, 2023 Category: Cytology Authors: Rachel Elizabeth Hicks Mohammed Alsabri Mario Peichev Viswanathan Kusum Source Type: research

Anti-Spike Antibody Responses in Allogeneic Stem Cell Transplant Recipients to Two Doses of COVID-19 mRNA Vaccination: A Retrospective, Single-Center Analysis
J Adv Pract Oncol. 2023 Jul;14(5):367-371. doi: 10.6004/jadpro.2023.14.5.2. Epub 2023 Jul 1.ABSTRACTAllogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients were excluded from the initial SARS-CoV-2 mRNA vaccination efficacy trials. Suboptimal vaccine responses have been reported in immunocompromised cohorts such as patients with solid tumors or hematologic malignancies, suggesting the need for additional research. Widespread data on the antibody responses and vaccine efficacy in allo-HSCT recipients is limited. In our single-center, retrospective study, we analyzed the anti-spike IgG antibody responses in...
Source: Adv Data - August 14, 2023 Category: Epidemiology Authors: Jaime L Shahan Robert H Collins Prapti Patel Yazan F Madanat Madhuri Vusirikala Source Type: research

Antibody response after third dose of COVID-19 mRNA vaccination in allogeneic hematopoietic stem cell transplant recipients is comparable to that in healthy counterparts
Int J Hematol. 2023 Aug 10. doi: 10.1007/s12185-023-03648-1. Online ahead of print.ABSTRACTTo determine the efficacy of SARS-CoV-2 mRNA vaccination for allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients, we measured antibody titer serially in 92 allo-HSCT patients. Among the evaluable 87 patients, median age at vaccination was 53 years (range, 18-75). The average time between allo-HSCT and vaccination was 3.3 years (range, 0.5-15.7). One month after the second dose, 70 patients (80.5%) had a positive response, whereas 17 patients (19.5%) had a negative response (< 20 U/mL). Only patients older tha...
Source: International Journal of Hematology - August 10, 2023 Category: Hematology Authors: Erina Takagi Seitaro Terakura Hidetsugu Fujigaki Akinao Okamoto Kotaro Miyao Masashi Sawa Takanobu Morishita Tatsunori Goto Yukiyasu Ozawa Tetsuya Nishida Nobuaki Fukushima Kazutaka Ozeki Ryo Hanajiri Kuniaki Saito Makoto Murata Akihiro Tomita Hitoshi Kiy Source Type: research