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Infectious Disease: Bird Flu
Vaccination: Swine Flu (H1N1) Vaccine
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Total 53 results found since Jan 2013.
Interspecies Transmission of Swine Influenza A Viruses and Human Seasonal Vaccine-Mediated Protection Investigated in Ferret Model
Emerg Infect Dis. 2023 Sep;29(9):1798-1807. doi: 10.3201/eid2909.230066.ABSTRACTWe investigated the infection dynamics of 2 influenza A(H1N1) virus isolates from the swine 1A.3.3.2 (pandemic 2009) and 1C (Eurasian, avian-like) lineages. The 1C-lineage virus, A/Pavia/65/2016, although phylogenetically related to swine-origin viruses, was isolated from a human clinical case. This strain infected ferrets, a human influenza model species, and could be transmitted by direct contact and, less efficiently, by airborne exposure. Infecting ferrets and pigs (the natural host) resulted in mild or inapparent clinical signs comparable ...
Source: Emerging Infectious Diseases - August 23, 2023 Category: Infectious Diseases Authors: Pauline M van Diemen Alexander M P Byrne Andrew M Ramsay Samantha Watson Alejandro Nunez Ana V Moreno Chiara Chiapponi Emanuela Foni Ian H Brown Sharon M Brookes Helen E Everett Source Type: research
An Advax-CpG adjuvanted recombinant H5 hemagglutinin vaccine protects mice against lethal influenza infection
This study tested the ability of adjuvants based on delta inulin (Advax™) alone or combined with a TLR9 agonist (Advax-CpG™) to enhance the immunogenicity of recombinant H5 hemagglutinin antigen expressed in insect cells (rH5HA) to protect mice against lethal influenza infection. The Advax-adjuvanted rH5HA induced high serum hemagglutination inhibition activity, as well as Th1 and Th2 cytokine secreting CD4 and CD8 T cells. Immunization protected mice against a lethal heterosubtypic H5N1 virus challenge. Mice immunized with an Advax-adjuvanted rHA2 stem antigen prepared by enzymatic cleavage of rH5HA produced serum ant...
Source: Vaccine - August 11, 2023 Category: Allergy & Immunology Authors: Yoshikazu Honda-Okubo E Bart Tarbet Brett L Hurst Nikolai Petrovsky Source Type: research
Sodium taurocholate hydrate inhibits influenza virus replication and suppresses influenza a Virus-triggered inflammation in vitro and in vivo
Int Immunopharmacol. 2023 Jun 29;122:110544. doi: 10.1016/j.intimp.2023.110544. Online ahead of print.ABSTRACTInfluenza A virus is an important respiratory pathogen that poses serious threats to human health. Owing to the high mutation rate of viral genes, weaker cross-protection of vaccines, and rapid emergence of drug resistance, there is an urgent need to develop new antiviral drugs against influenza viruses. Taurocholic acid is a primary bile acid that promotes digestion, absorption, and excretion of dietary lipids. Here, we demonstrate that sodium taurocholate hydrate (STH) exhibits broad-spectrum antiviral activity a...
Source: International Immunopharmacology - July 1, 2023 Category: Allergy & Immunology Authors: Xiaolu Sun Xiaotong Hu Qiang Zhang Li Zhao Xiaomei Sun Li Yang Meilin Jin Source Type: research
Could chatbots help devise the next pandemic virus?
Tech experts have been sounding the alarm that artificial intelligence (AI) could turn against humanity by taking over everything from business to warfare. Now, Kevin Esvelt is adding another worry: AI could help somebody with no science background and evil intentions design and order a virus capable of unleashing a pandemic.
Esvelt, a biosecurity expert at the Massachusetts Institute of Technology, recently asked students to create a dangerous virus with the help of ChatGPT or other so-called large language models, systems that can generate humanlike responses to broad questions based on vast training sets of interne...
Source: ScienceNOW - June 14, 2023 Category: Science Source Type: news
Cost-effectiveness of routine annual influenza vaccination by age and risk status
CONCLUSIONS: Cost-effectiveness of influenza vaccination varied by age and risk status and was less than $95,000/QALY for all subgroups, except for non-high-risk working-age adults. Results were sensitive to the probability of influenza illness and vaccination was more favorable under certain scenarios. Vaccination for higher risk subgroups resulted in ICERs below $100,000/QALY even at low levels of vaccine effectiveness or circulating virus.PMID:37291022 | DOI:10.1016/j.vaccine.2023.04.069
Source: Vaccine - June 8, 2023 Category: Allergy & Immunology Authors: Ellen Kim DeLuca Acham Gebremariam Angela Rose Matthew Biggerstaff Martin I Meltzer Lisa A Prosser Source Type: research
Monoclonal antibody targeting a novel linear epitope on nucleoprotein confers pan-reactivity to influenza A virus
Appl Microbiol Biotechnol. 2023 Feb 23:1-14. doi: 10.1007/s00253-023-12433-3. Online ahead of print.ABSTRACTNucleoprotein (NP) functions crucially in the replicative cycle of influenza A virus (IAV) via forming the ribonucleoprotein complex together with PB2, PB1, and PA proteins. As its high conservation, NP ranks one of the hot targets for design of universal diagnostic reagents and antiviral drugs for IAV. Here, we report an anti-NP murine monoclonal antibody (mAb) 5F10 prepared from traditional lymphocyte hybridoma technique with the immunogen of a clade 2.3.4.4 H5N1 subtype avian influenza virus. The specificity of mA...
Source: Applied Microbiology and Biotechnology - February 23, 2023 Category: Microbiology Authors: Min Gu Jun Jiao Suhan Liu Wanchen Zhao Zhichuang Ge Kairui Cai Lijun Xu Dongchang He Xinyu Zhang Xian Qi Wenming Jiang Pinghu Zhang Xiaoquan Wang Shunlin Hu Xiufan Liu Source Type: research
JMM Profile: Swine influenza A virus: a neglected virus with pandemic potential
J Med Microbiol. 2023 Jan;72(1). doi: 10.1099/jmm.0.001623.ABSTRACTSwine influenza is an acute respiratory disease of swine caused by swine influenza A virus (SwIAV). The ability of SwIAV to spread bidirectionally from animals to humans (zoonotic), and from humans to animals (reverse zoonotic), drives coinfection that can result in gene segment exchange and elevates the risk of generating viruses with pandemic potential. Compared to human-origin influenza A viruses, current data indicate a greater diversity amongst circulating SwIAVs, with three major subtypes (classified by haemagglutinin and neuraminidase) circulating gl...
Source: Journal of Medical Microbiology - February 7, 2023 Category: Microbiology Authors: Benjamin C Mollett Helen E Everett Pauline M van Diemen Alexander M P Byrne Andrew Ramsay Joe James Scott M Reid Rowena D E Hansen Nicola S Lewis Ian H Brown Ashley C Banyard Source Type: research
Cold-passaged isolates and bat-swine influenza a chimeric viruses as modified live-attenuated vaccines against influenza a viruses in pigs
Vaccine. 2022 Sep 19:S0264-410X(22)01108-2. doi: 10.1016/j.vaccine.2022.09.013. Online ahead of print.ABSTRACTSwine influenza A virus (swIAV) infections in pig populations cause considerable morbidity and economic losses. Frequent reverse zoonotic incursions of human IAV boost reassortment opportunities with authentic porcine and avian-like IAV in swine herds potentially enhancing zoonotic and even pre-pandemic potential. Vaccination using adjuvanted inactivated full virus vaccines is frequently used in attempting control of swIAV infections. Accelerated antigenic drift of swIAV in large swine holdings and interference of ...
Source: Vaccine - September 22, 2022 Category: Allergy & Immunology Authors: Annika Graaf Philipp P Petric Julia Sehl-Ewert Dinah Henritzi Angele Breithaupt Jacqueline King Anne Pohlmann Fabian Deutskens Martin Beer Martin Schwemmle Timm Harder Source Type: research
