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Infectious Disease: Bird Flu
Vaccination: Influenza Vaccine
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Total 397 results found since Jan 2013.
Evaluation the effect of dietary vitamin E, sesamin and thymoquinone bioactive compounds on immunological response, intestinal traits and MUC-2 gene expression in broiler Japanese quails ( < em > Coturnix japonica < /em > )
Anim Biotechnol. 2023 Sep 20:1-11. doi: 10.1080/10495398.2023.2259437. Online ahead of print.ABSTRACTThe current study was performed to determine the effect of dietary vitamin E, sesamin and thymoquinone bioactive lignans derived from sesame and black seed on immunological response, intestinal traits and Mucin2 gene expression in broiler quails. Three hundred and fifty (one days-old) quails were allotted to seven dietary treatments with five replicates as an experimental randomized design study. Treatments were basal diet as a control, control +100 and +200 mg of vitamin E, sesamin and thymoquinone per each kg of diet resp...
Source: Animal Biotechnology - September 20, 2023 Category: Biotechnology Authors: Yaser Rahimian Farshid Kheiri Mostafa Faghani Source Type: research
Salmonella delivers H9N2 influenza virus antigens via a prokaryotic and eukaryotic dual-expression vector and elicits bivalent protection against avian influenza and fowl typhoid
Dev Comp Immunol. 2023 Sep 13:105058. doi: 10.1016/j.dci.2023.105058. Online ahead of print.ABSTRACTThe H9N2 avian influenza virus significantly affects the health of poultry and humans. We identified a prokaryotic and eukaryotic dual-expression vector system, pJHL270, that can provide simultaneous MHC class I and II stimulation of the host immune system, and we designed vaccine antigens by selecting the consensus HA1 sequence and M2e antigens from H9N2 virus circulating in South Korea from 2000 to 2021. The genes were cloned into the pJHL270 vector, and the cloned plasmid was delivered by a live-attenuated Salmonella Gall...
Source: Developmental and Comparative Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Chamith Hewawaduge Jun Kwon Chandran Sivasankar Ji-Young Park Amal Senevirathne John Hwa Lee Source Type: research
HVT-vectored H7 vaccine protects chickens from lethal infection with the highly pathogenic H7N9 Avian in fluenza virus
Vet Microbiol. 2023 Aug 20;285:109852. doi: 10.1016/j.vetmic.2023.109852. Online ahead of print.ABSTRACTSince mid-2016, the highly pathogenic H7N9 subtype avian influenza virus (AIV) has threatened both public health and the poultry industry. Although a vaccination strategy has been deemed imperative to manage the virus, the most commonly used inactivated vaccines today are susceptible to interference from maternal antibodies and associated with an over-reliance on humoral immunity. In response, we developed a recombination vaccine with the herpesvirus of turkeys (HVT) as the vector to squeeze HPAI H7N9 and assessed its pr...
Source: Herpes - September 8, 2023 Category: Infectious Diseases Authors: Yi-Qun Chen Guan-Ming Su Jia-Hao Zhang Bo Li Kai-Xiong Ma Xu Zhang Li-Hong Huang Ming Liao Wen-Bao Qi Source Type: research
Interspecies Transmission of Swine Influenza A Viruses and Human Seasonal Vaccine-Mediated Protection Investigated in Ferret Model
Emerg Infect Dis. 2023 Sep;29(9):1798-1807. doi: 10.3201/eid2909.230066.ABSTRACTWe investigated the infection dynamics of 2 influenza A(H1N1) virus isolates from the swine 1A.3.3.2 (pandemic 2009) and 1C (Eurasian, avian-like) lineages. The 1C-lineage virus, A/Pavia/65/2016, although phylogenetically related to swine-origin viruses, was isolated from a human clinical case. This strain infected ferrets, a human influenza model species, and could be transmitted by direct contact and, less efficiently, by airborne exposure. Infecting ferrets and pigs (the natural host) resulted in mild or inapparent clinical signs comparable ...
Source: Emerging Infectious Diseases - August 23, 2023 Category: Infectious Diseases Authors: Pauline M van Diemen Alexander M P Byrne Andrew M Ramsay Samantha Watson Alejandro Nunez Ana V Moreno Chiara Chiapponi Emanuela Foni Ian H Brown Sharon M Brookes Helen E Everett Source Type: research
Identification of catalytically active domain epitopes in neuraminidase protein of H9N2 subtype of avian influenza virus
In this study, a truncated NA gene (205-900 bp) was cloned from the NA sequence of H9N2 strain, and then expressed using pET-28a (+) vector. This purified recombinant NA protein was used to immunize BALB/c mice, and the monoclonal antibodies were screened through the indirect enzyme-linked immunosorbent assay (ELISA). Next, eight prokaryotic expression vectors were constructed for epitope identification. After cell fusion, three hybridoma cell lines producing the antibodies special to NA protein were screened by ELISA, western blotting, and indirect immunofluorescence; these were named 1B10, 2B6, and 5B2, respectively. Epi...
Source: Avian Pathology - August 15, 2023 Category: Pathology Authors: Xiangyu Huang Yiqin Cai Guihu Yin Zili Chen Jianing Hu Zichen Gao Xinyu Guo Fuqiang Xiong Xiuli Feng Source Type: research
An immune-enhanced multivalent DNA nanovaccine to prevent H7 and H9 avian influenza virus in mice
Int J Biol Macromol. 2023 Aug 12:126286. doi: 10.1016/j.ijbiomac.2023.126286. Online ahead of print.ABSTRACTH7 avian influenza virus has caused multiple human infections and poses a severe public health threat. In response to the highly variable nature of AIVs, a novel, easily regenerated DNA vaccine has great potential in treating or preventing avian influenza pandemics. Nevertheless, DNA vaccines have many disadvantages, such as weak immunogenicity and poor in vivo delivery. To further characterize and solve these issues and develop a novel H7 AIV DNA vaccine with enhanced stability and immunogenicity, we constructed nin...
Source: International Journal of Biological Macromolecules - August 14, 2023 Category: Biochemistry Authors: Shangen Xu Hailing Lan Qiaoyang Teng Xuesong Li Zheng Jin Yang Qu Jiawei Li Qihong Zhang Hong Kang Tan Hui Yin Zejun Li Kai Zhao Source Type: research
