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Clinical and radiological characteristics and predictors of outcome of cerebral venous sinus thrombosis, a hospital-based study
AbstractCerebral venous sinus thrombosis is an uncommon cause of stroke, which is more prevalent in Iran and the Middle East. We aimed to assess the etiology, radiologic, and clinical manifestations of cerebral venous sinus thrombosis, specifically the predictors of patients ’ outcome in Namazi hospital, Shiraz, Iran. In this retrospective study, we included all adult patients with the diagnosis of cerebral venous sinus thrombosis, who were admitted in hospital, from 2012 to 2016. Demographic data, radiologic findings, clinical presentation, risk factors, treatment, a nd outcome according to modified Rankin Scale (mRS) o...
Source: Acta Neurologica Belgica - September 3, 2018 Category: Neurology Source Type: research

The predictive dysphagia score (PreDyScore) in the short- and medium-term post-stroke: a putative tool in PEG indication
ConclusionBMI<  20 and mRS ≥ 3 are easily measurable bedside predictive factors of persistent dysphagia. PreDyScore showed good sensitivity and very good specificity and enables the prediction of persistent dysphagia with great accuracy in any clinical setting.
Source: Neurological Sciences - April 18, 2019 Category: Neurology Source Type: research

Prolonged Heightened Blood Pressure Following Mechanical Thrombectomy for Acute Stroke is Associated with Worse Outcomes
ConclusionHigh daily maximum SBP and a rebound SBP on the third day following MT is independently associated with increased likelihood of functional dependence.
Source: Neurocritical Care - August 4, 2019 Category: Neurology Source Type: research

Invasiveness and Clinical Outcomes of Off-Hour Admissions in Patients with Intracerebral Hemorrhage
Background: Whether time of hospital admission —during or outside regular working hours—affects functional outcome in intracerebral hemorrhage (ICH) is unestablished as previous analyses have focused on mortality only. We here investigate whether on- versus off-hour hospital admission in ICH is associated with levels of invasiveness and clin ical outcomes. Methods: Based on the UKER registry (NCT03183167) we grouped ICH-patients according to on- versus off-hour hospital admission. Primary outcome measures was functional outcome after 3 months using the modified Rankin scale (mRS) dichotomized into favorable (mRS = ...
Source: Journal of Stroke and Cerebrovascular Diseases - November 26, 2019 Category: Neurology Authors: Anne Mrochen, Maximilian I. Spr ügel, Stefan T. Gerner, Dominik Madžar, Joji B. Kuramatsu, Philip Hoelter, Hannes Lücking, Stefan Schwab, Hagen B. Huttner Source Type: research

Plasma Neurofilament Light Chain Is Associated with Poor Functional Outcome and Mortality Rate After Spontaneous Subarachnoid Hemorrhage
AbstractThe initial clinical status after subarachnoid hemorrhage (SAH) is an important outcome predictor, but the mechanisms behind the early brain injury (EBI) remains incompletely understood. Elevated neurofilament levels in the cerebrospinal fluid at protracted stages after SAH are associated with poor outcome, but the potential association between plasma neurofilament (pNfL) levels during EBI, disease severity on admission, and poor outcome remains unaddressed. Plasma NfL (pNfL) was measured by single molecule array in 44 SAH patients on admission and 24  h after ictus, as well as in 44 controls. Disease severity on ...
Source: Translational Stroke Research - December 4, 2019 Category: Neurology Source Type: research

Nontraumatic spontaneous intracerebral hemorrhage: Baseline characteristics and early outcomes
ConclusionThe present study showed that SICH is a serious disease causing high mortality and disability, particularly in the early period after event.
Source: Brain and Behavior - December 14, 2019 Category: Neurology Authors: Mohamed Al ‐Khaled, Samer Awwad, Toralf Brüning Tags: ORIGINAL ARTICLE Source Type: research

Relationship of White Matter Lesions with Intracerebral Hemorrhage Expansion and Functional Outcome: MISTIE II and CLEAR III
ConclusionsConcomitant WML does not increase the odds for HE in patients with ICH but increases the odds for poor functional outcome.Clinical Trial Registrationhttp://www.clinicaltrials.gov trial-identifiers: NCT00224770 and NCT00784134.
Source: Neurocritical Care - February 4, 2020 Category: Neurology Source Type: research

Carotid Stenting as Definitive Treatment for Free Floating Thrombus —Review of 7 Cases
ConclusionFree floating thrombus of the carotid arteries can be managed with stenting.
Source: Clinical Neuroradiology - March 26, 2020 Category: Neurology Source Type: research

Late Thrombectomy in Clinical Practice
ConclusionIn clinical practice, the high number of patients with a  good clinical outcome after endovascular therapy ≥ 6–24 h as in DAWN/DEFUSE3 could not be achieved. Similar outcomes are seen in patients selected for EVT ≥ 6 h based on factors other than CTP. Patients triaged without CTP showed trends for shorter arrival to reperfusion times and higher rates of independence.
Source: Clinical Neuroradiology - June 7, 2021 Category: Neurology Source Type: research

Mechanical Thrombectomy for Pediatric Large Vessel Occlusions
ConclusionIn our meta-analysis, MT demonstrated a  promising safety and efficacy profile for pediatric patients, with consistently high efficacy outcomes and low complication rates. Our results support the utilization of MT in pediatric LVOs; however, prospective studies are still needed to further establish the role of pediatric MT as a first-li ne treatment strategy.
Source: Clinical Neuroradiology - January 2, 2023 Category: Neurology Source Type: research

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