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Hosimosines A-E, structurally diverse cytisine derivatives from the seeds of Ormosia hosiei Hemsl. et Wils
Fitoterapia. 2023 Aug 28:105661. doi: 10.1016/j.fitote.2023.105661. Online ahead of print.ABSTRACTOrmosia hosiei Hemsl. et Wils (Fabaceae family) is an arbor species endemic to China. The seeds of O. hosiei have been used as traditional Chinese medicine to treat hernia, abdominal pain, blood stasis and amenorrhea. Cytisine-like and angustifoline type alkaloids were main components identified from this plant. In our research on the bioactive alkaloids from the promising Chinese medicinal plants, four new angustifoline type alkaloids (1-4) and a new cytisine-like alkaloid (5), named hosimosine A-E, together with 13 known ana...
Source: Fitoterapia - August 30, 2023 Category: Biochemistry Authors: Qing-Qing Zhou Xiao-Yan Xie Jia-Wen Zhu Wei-Wei Pan Bao-Gang Xie Wu Zhou Jin-Biao Xu Source Type: research

Chemical composition and evaluation of the antinociceptive, antioxidant and antimicrobial effects of essential oil from Hymenaea cangaceira (Pinto, Mansano & Azevedo) native to Brazil: A natural medicine
ConclusionOur results validate the main activities by the traditional use attributed to H. cangaceira for antimicrobial and analgesic activity. In addition, the oil has a potent antioxidant activity, protecting the body against oxidative stress damage, adding new value to an endemic species not known to the industry.Graphical abstract
Source: Journal of Ethnopharmacology - October 2, 2019 Category: Drugs & Pharmacology Source Type: research

Medicinal Properties and Active Constituents of Dracocephalum kotschyi and Its Significance in Iran: A Systematic Review.
Conclusion: This review has shown that D. kotschyi is an important medicinal plant with a large number of active constituents and great potential to safeguard human and animal health in Iran. However, over utilization of the D. kotschyi plant is already endangering its existence. Nevertheless, more studies need be conducted across the country. PMID: 31198431 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - June 16, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Astragalin Promotes Osteoblastic Differentiation in MC3T3-E1 Cells and Bone Formation in vivo
This study was carried out in accordance with the recommendations of the NIH guidelines for the care and use of laboratory animals. The protocol was approved by the Committees of Animal Ethics and Experimental Safety of Binzhou Medical University. Author Contributions DL supervised the whole project. LL, DW, and DL performed the major research and wrote the manuscript with equal contributions. YQ, MX, LZ, WX, XL, and LY provided technical support. SY and QZ provided their professional expertise. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financ...
Source: Frontiers in Endocrinology - April 15, 2019 Category: Endocrinology Source Type: research

Use of plants in oral health care by the population of Mahajanga, Madagascar
Conclusion This ethnobotanical survey will serve as database for further phytochemical and pharmacological study of plants in order to identify their active components and advise the population on the most effective administration. Graphical abstract
Source: Journal of Ethnopharmacology - August 12, 2016 Category: Drugs & Pharmacology Source Type: research

"It's A Scandal" -Daryl Hall on Doctors Denying Chronic Lyme
Growing up a musically-obsessed child in the 80's, Daryl Hall was one of my biggest inspirations. A masterful, inventive songwriter with an ocean of soul, he set me on the path to being an artist, to never waste a word, and to sing because I mean it. With six number ones and five additional top ten hits throughout the 70's and 80's Daryl Hall and John Oates are the number one duo in music history. Still at the top of his game at 69 years old, Daryl has won legions of new fans with his hit MTV Live show Live From Daryl's House. In February of 2015, at my very sickest from chronic Lyme and Bartonella, after it was missed b...
Source: Science - The Huffington Post - July 22, 2016 Category: Science Source Type: news

Toxicity and antinociceptive effects of Hamelia patens
Abstract Many medicinal herbs are used in folk medicine without taking into account their toxicity. Hamelia patens Jacq. (Rubiaceae), a Mexican endemic species, is used for the empirical treatment of pain. The aim of this work was to evaluate the toxicity and antinociceptive effects of ethanolic extracts of H. patens leaves. The toxicity of H. patens leaves (500–5000 mg/kg) was evaluated in acute (14 days) and subacute (28 days) assays. In the subacute assay, a blood analysis (both hematology and chemistry) was carried out. The antinociceptive effects of H. patens leaves (50–200 mg/kg) were evaluated using thermal-indu...
Source: Revista Brasileira de Farmacognosia - June 27, 2015 Category: Drugs & Pharmacology Source Type: research