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Infectious Disease: Cytomegalovirus
Procedure: Transplants
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Total 1302 results found since Jan 2013.
A quick algorithmic review on management of viral infectious diseases in pediatric solid organ transplant recipients
Front Pediatr. 2023 Sep 4;11:1252495. doi: 10.3389/fped.2023.1252495. eCollection 2023.ABSTRACTPediatric solid organ transplant is a life-saving procedure for children with end-stage organ failure. Viral infections are a common complication following pediatric solid organ transplantation (SOT), which can lead to increased morbidity and mortality. Pediatric solid organ transplant recipients are at an increased risk of viral infections due to their immunosuppressed state. The most commonly encountered viruses include cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus (HSV), varicella-zoster virus (VZV), ad...
Source: Herpes - September 21, 2023 Category: Infectious Diseases Authors: Marjan Moghadamnia Hamid Eshaghi Hosein Alimadadi Simin Dashti-Khavidaki Source Type: research
Research for Cytomegalovirus Mutations Associated With Resistance to Antivirals in Kidney Transplant Receptors
Cell Transplant. 2023 Jan-Dec;32:9636897231195245. doi: 10.1177/09636897231195245.ABSTRACTCytomegalovirus (CMV) mutations associated with antiviral resistance have become a major problem related to high mortality in kidney transplant patients. The aim of the study was to investigate mutations in the CMV genes UL97 and UL54 associated with antiviral resistance. A retrospective observational cohort study was carried out at Hospital Ophir Loyola (HOL), a reference in Kidney Transplantation. A total of 81 patients who underwent kidney transplantation were followed up between 2016 and 2018 were monitored for CMV viral load by p...
Source: Cell Transplantation - September 19, 2023 Category: Cytology Authors: Carla de Castro Sant' Anna Silvia Regina da Cruz Migone Carlos Alberto Machado da Rocha Fernando Augusto Rodrigues Mello J únior Aline Damasceno Seabra Tha ís Brilhante Pontes Jo ão Marildo Rodrigues Salom é Aparecida Soares Viviane de Paiva Rego Joan Source Type: research
Macrophage colony-stimulating factor as a weapon against cytomegalovirus
EMBO Mol Med. 2023 Sep 12:e18319. doi: 10.15252/emmm.202318319. Online ahead of print.ABSTRACTCytomegalovirus (CMV) infection is one of the severe opportunistic infections faced by severely immunocompromised patients. High viral loads cause tissue-invasive disease and expose to death or various indirect effects. Substantial progress was made in monitoring active infection, and antiviral drugs were developed. However, dose-limiting toxicities and genotypic resistance limit therapeutic efficacy and vaccine development is hampered by the complex biology of the virus. In this issue of EMBO Molecular Medicine, Kandalla et al (2...
Source: Molecular Medicine - September 12, 2023 Category: Molecular Biology Authors: Eric Solary Source Type: research
Markers of terminally differentiated T-cells as predictors of vascular health in renal transplant recipients and healthy adults
Clin Immunol. 2023 Sep 5:109760. doi: 10.1016/j.clim.2023.109760. Online ahead of print.ABSTRACTMeta-analyses confirm a link between persistent human cytomegalovirus (HCMV) infections and cardiovascular disease, but the mechanisms are unclear. We assess whether proportions of T-cell populations are reliable predictors of subclinical atherosclerosis and/or reflect the burden of HCMV in healthy adults and renal transplant recipients (RTR). Samples were collected from healthy adults and RTR at baseline (T0) and after 32 (24-40) months (T1). Left carotid intima media thickness (cIMT) and proportions of T-cells expressing CD57,...
Source: Clinical Immunology - September 7, 2023 Category: Allergy & Immunology Authors: Silvia Lee HuiJun Chih Jacquita Affandi Shelley Waters Ashley Irish Patricia Price Source Type: research
Etiology and clinical characteristics of acute viral hepatitis in South Korea during 2020-2021: a prospective multicenter study
Sci Rep. 2023 Aug 31;13(1):14271. doi: 10.1038/s41598-023-40775-5.ABSTRACTThis prospective, 12-center study investigated the etiology and clinical characteristics of acute viral hepatitis (AVH) during 2020-2021 in South Korea, and the performance of different diagnostic methods for hepatitis E virus (HEV). We enrolled 428 patients with acute hepatitis, of whom 160 (37.4%) were diagnosed with AVH according to predefined serologic criteria. The clinical data and risk factors for AVH were analyzed. For hepatitis E patients, anti-HEV IgM and IgG were tested with two commercial ELISA kits (Abia and Wantai) with HEV-RNA real-tim...
Source: Herpes - August 31, 2023 Category: Infectious Diseases Authors: Chan Young Jeong Gwang Hyeon Choi Eun Sun Jang Young Seok Kim Youn-Jae Lee In Hee Kim Sung Bum Cho Jae Hyun Yoon Kyung-Ah Kim Dae Hee Choi Woo Jin Chung Hyun-Jin Cho Seong Kyun Na Yun-Tae Kim Byung Seok Lee Sook-Hyang Jeong Source Type: research
M-CSF directs myeloid and NK cell differentiation to protect from CMV after hematopoietic cell transplantation
EMBO Mol Med. 2023 Aug 28:e17694. doi: 10.15252/emmm.202317694. Online ahead of print.ABSTRACTTherapies reconstituting autologous antiviral immunocompetence may represent an important prophylaxis and treatment for immunosuppressed individuals. Following hematopoietic cell transplantation (HCT), patients are susceptible to Herpesviridae including cytomegalovirus (CMV). We show in a murine model of HCT that macrophage colony-stimulating factor (M-CSF) promoted rapid antiviral activity and protection from viremia caused by murine CMV. M-CSF given at transplantation stimulated sequential myeloid and natural killer (NK) cell di...
Source: Molecular Medicine - August 28, 2023 Category: Molecular Biology Authors: Prashanth K Kandalla Julien Subburayalu Cl ément Cocita B érengère de Laval Elena Tomasello Johanna Iacono Jessica Nitsche Maria M Canali Wilfried Cathou Gilles Bessou Noushin Mossadegh-Keller Caroline Huber Guy Mouchiroud Roland P Bourette Marie-Franc Source Type: research
Impact of Baseline and Week 2 and Week 4 Posttransplant CMV Cell-Mediated Immunity on Risk of CMV Infections and Mortality in Recipients of Allogeneic Hematopoietic Cell Transplant
CONCLUSIONS: A decrease in CMV-specific T-cell responses during the first month after transplant may predict CS-CMVi and is associated with all-cause mortality in recipients of alloHCT.PMID:37636519 | PMC:PMC10460252 | DOI:10.1093/ofid/ofad386
Source: Cancer Control - August 28, 2023 Category: Cancer & Oncology Authors: Ella J Ariza-Heredia Drew J Winston Scott D Rowley Kathleen Mullane Pranatharthi Chandrasekar Parameswaran Hari Robin K Avery Karl S Peggs Deepali Kumar Rajneesh Nath Per Ljungman Sherif B Mossad Lynn El Haddad Dimpy P Shah Ying Jiang Fareed Khawaja Sanje Source Type: research
Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients
CONCLUSIONS: Baseline maribavir resistance was rare. Drug resistance to standard cytomegalovirus antivirals did not preclude treatment response to maribavir. Rebound in plasma cytomegalovirus DNA while on maribavir strongly suggests emerging drug resistance.CLINICAL TRIALS REGISTRATION: NCT02931539 (SOLSTICE).PMID:37506264 | DOI:10.1093/infdis/jiad293
Source: Cancer Control - July 28, 2023 Category: Cancer & Oncology Authors: Sunwen Chou Sophie Alain Carlos Cervera Roy F Chemaly Camille N Kotton Jens Lundgren Genovefa A Papanicolaou Marcus R Pereira Jingyang J Wu Rose Ann Murray Neil E Buss Martha Fournier Source Type: research
Impact of Early Natural Killer Cell Reconstitution on the Outcomes of T Cell-Replete Allogeneic Hematopoietic Stem Cell Transplantation
CONCLUSION: Rapid NK cell reconstitution early after allo-HSCT had protective effects on NRM and survival. Promoting early NK cell reconstitution represents a new approach to improving the outcomes of allo-HSCT.PMID:37489148 | PMC:PMC10363384 | DOI:10.2147/JIR.S416708
Source: Cell Research - July 25, 2023 Category: Cytology Authors: Ziwei Zhou Xuan Liu Xuejun Zhang Shupeng Wen Huan Hua Zhenzhen Wang Zheng Xu Yu Lu Fuxu Wang Source Type: research
High levels of NK Cells in graft are associated with reduced febrile neutropenia after haploidentical peripheral blood stem cell transplantation
CONCLUSION: A high number of NK cells in the graft may reduce febrile neutropenia, IFD and bacterial infection following haplo-PBSCT but it has no significant effect on aGVHD, PFS, or OS.PMID:37480280 | DOI:10.1177/03000605231187932
Source: Cell Research - July 22, 2023 Category: Cytology Authors: Caili Guo Xinyan Li Miaojing Li Pengcheng He Wenjuan Wang Xiaoning Wang Source Type: research
