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Safety of tPA + Transcranial Emission of Low-Energy Lasers for Acute Stroke Recovery - Results (P4.219)
Conclusion: Transcranial Laser in this small exploratory study was well tolerated in combination with IV tPA. Larger studies are needed to explore if the combination of LASER therapy plus tPA is safe and shows better outcome than IV tPA alone.Study supported by NIH Grant P50 NS044148Clinical Trial Registry: NCT01220739Disclosure: Dr. Hemmen has nothing to disclose. Dr. Raman has nothing to disclose. Dr. Sen has received personal compensation for activities with Genentech Inc., Sanofi Aventis Pharmaceutical Inc., Bristol-Myers Squibb Co., and Boehringer Ingelheim Pharmaceuticals Inc. Dr. Sen has received research support fr...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Hemmen, T., Raman, R., Sen, S., Geraghty, M., Rapp, K., Richeri, S., Meyer, B., Zivin, J., Fanale, C. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Thrombolysis Source Type: research

Transcranial Laser Therapy in Acute Stroke Treatment: Results of Neurothera Effectiveness and Safety Trial 3, a Phase III Clinical End Point Device Trial Major Clinical Trial
Conclusions— Once the results of the interim futility analysis became available, all study support was immediately withdrawn by the capital firms behind PhotoThera, and the company was dissolved. Proper termination of the trial was difficult but was finally achieved through special efforts by former employees of PhotoThera, the CRO Parexel and members of the steering and the safety committees. We conclude that transcranial laser therapy does not have a measurable neuroprotective effect in patients with acute ischemic stroke when applied within 24 hours after stroke onset. Clinical Trial Registration— URL: http...
Source: Stroke - October 27, 2014 Category: Neurology Authors: Hacke, W., Schellinger, P. D., Albers, G. W., Bornstein, N. M., Dahlof, B. L., Fulton, R., Kasner, S. E., Shuaib, A., Richieri, S. P., Dilly, S. G., Zivin, J., Lees, K. R., for the NEST 3 Committees and Investigators, Broderick, Ivanova, Johnston, Norrvin Tags: Acute Cerebral Infarction Major Clinical Trial Source Type: research

A Novel Method to Promote Behavioral Improvement and Enhance Mitochondrial Function Following An Embolic Stroke.
This study demonstrates that the combination of TLT-tPA enhances ATP production, and suggests that tPA-induced reperfusion in combination with TLT neuroprotection therapy may optimally protect viable cells in the cortex measured using ATP levels as a marker. PMID: 27180104 [PubMed - as supplied by publisher]
Source: Brain Research - May 10, 2016 Category: Neurology Authors: Lapchak PA, Boitano PD Tags: Brain Res Source Type: research

Effects of low-level laser therapy (LLLT 808  nm) on lower limb spastic muscle activity in chronic stroke patients
AbstractA cerebrovascular accident (CVA) may affect basic motor functions, including spasticity that may be present in the upper extremity and/or the lower extremity, post-stroke. Spasticity causes pain, muscle force reduction, and decreases the time to onset of muscle fatigue. Several therapeutic resources have been employed to treat CVA to promote functional recovery. The clinical use of low-level laser therapy (LLLT) for rehabilitation of muscular disorders has provided better muscle responses. Thus, the aim of this study was to evaluate the effect of the application of LLLT in spastic muscles in patients with spasticit...
Source: Lasers in Medical Science - August 25, 2016 Category: Laser Surgery Source Type: research

Transcranial Laser Therapy and Infarct Volume Brief Reports
Conclusions— TLT was not associated with a reduction in overall or cortical infarct volume as measured on computed tomography in the subacute phase.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Kasner, S. E., Rose, D. Z., Skokan, A., Walker, M. G., Shi, J., Streeter, J., the NEST-2 Steering Committee and Investigators Tags: Acute Cerebral Infarction, Neuroprotectors Brief Reports Source Type: research

The effectiveness of high-intensity laser therapy in the treatment of post-stroke patients with hemiplegic shoulder pain: a prospective randomized controlled study
AbstractTo evaluate clinical and ultrasonographic efficacy of high-intensity laser therapy (HILT) in patients with hemiplegic shoulder pain (HSP) accompanied by partial thickness rotator cuff tear (PTRCT). The study was designed as a prospective, randomized, controlled trial. Patients with HSP accompanied by PTRCT (n = 44) were randomly assigned to HILT and control groups. Both groups were treated with a multidisciplinary stroke rehabilitation and a therapeutic exercise program to the affected shoulder supervised by physiotherapists. In addition, HILT group received 3 sessions of the intervention per week for 3 weeks. Prim...
Source: Lasers in Medical Science - April 8, 2021 Category: Laser Surgery Source Type: research

Effect of Low-Level Laser and Light-Emitting Diode on Inferior Alveolar Nerve Recovery After Sagittal Split Osteotomy of the Mandible: A Randomized Clinical Trial Study
Conclusion: Low-level laser therapy and light-emitting diode may improve VAS scores, 2-point discrimination, and brush stroke test results without any effect on the pinprick or contact detection test results.
Source: Journal of Craniofacial Surgery - June 1, 2017 Category: Surgery Tags: Brief Clinical Studies Source Type: research

Photomechanical effect of Q-switched ND:YAG laser enhance thrombolysis using of PLGA- based encapsulated tissue plasminogen activator (TPA) nanoparticles
Aim: Thrombus formation on a disrupted atherosclerotic plaque is a key event that leads to atherothrombosis. Atherothrombosis mediated acute clinical events such as myocardial infarction and stroke. The purpose of this study is to prepare encapsulated tissue plasminogen activator (tPA) and evaluate its effectiveness on thrombolysis using laser therapy in the rabbit model of atherothrombotic.
Source: Atherosclerosis - August 1, 2018 Category: Cardiology Authors: H. Mehrad, J. Mahmoudi, A. Keshavarz, A. Rahimkhani Source Type: research

Sensory-motor and cardiorespiratory sensory rehabilitation associated with transcranial photobiomodulation in patients with central nervous system injury: Trial protocol for a single-center, randomized, double-blind, and controlled clinical trial
Background: Central nervous system diseases such as stroke, spinal cord injury, traumatic brain injury, and multiple sclerosis can be fatal or cause sequelae, affecting sensorimotor and cardiorespiratory systems and quality of life. These subjects present a low response to aerobic and resistance exercise, due to decreased recruitment of muscle fibers and reduction of metabolic capacity. Aerobic exercises bring benefits in terms of fatigue retardation, gait improvement, regulation of the autonomic nervous system, neuroprotection of the brain, stimulation of the production of endogenous neutrotransmitters related to genera...
Source: Medicine - June 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Inertial cavitation-mediated catheter- based Q-switched Nd: YAG laser therapy in combination with extracorporeal electrohydraulic low- level focused shock wave therapy for thrombolysis of embolic artery
Background and Aims: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. The aim of this study was to generate a rabbit model of carotid artery thromboembolic occlusion and the subsequent investigating the feasibility of catheter- based Q-switched Nd: YAG laser therapy accompanied by simultaneously extracorporeal shock wave therapy in this model.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: H. Mehrad Source Type: research