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Total 299 results found since Jan 2013.

Recognition, identification, and diagnosis announcement of neonatal arterial ischemic stroke: A combined exploratory quantitative and qualitative study on parents' lived experiences
CONCLUSION: Maternity hospital caregivers' awareness of NAIS is crucial to reach early diagnosis. Improving this aspect would not only allow better early management, but also make it possible to set up acute neuroprotective strategies. Clinicians should be attentive to the modalities of diagnosis and prognosis announcements, which are associated with considerable stress and misconceptions.PMID:33715932 | DOI:10.1016/j.arcped.2021.02.002
Source: Archives de Pediatrie - March 15, 2021 Category: Pediatrics Authors: Cindy Leal Martins St éphane Chabrier Joel Fluss Source Type: research

High incidence of stroke and mortality in pediatric critical care patients with COVID-19 in Peru
CONCLUSION: Cerebrovascular events associated with COVID-19 in pediatric patients, including infants, must be recognized as one of the more severe presentations of this infection in pediatric patients.IMPACT: Pediatric patients with COVID-19 can present with hemorrhagic and ischemic strokes on presentation. Neurological presentation in pediatric patients with COVID-19 has high mortality. Mortality of pediatric patients with COVID-19 is associated with comorbidities. Pediatric presentation and outcomes of COVID-19 in different regions can be novel to previously described.PMID:33941862 | DOI:10.1038/s41390-021-01547-x
Source: Pediatric Research - May 4, 2021 Category: Pediatrics Authors: Alvaro Coronado Munoz Jaime Tasayco Willy Morales Luis Moreno David Zorrilla Angie Stapleton Patricia Pajuelo Giuliana Reyes Matilde Estupi ñan Ricardo Seminario Manuel Ortiz Jes ús Domínguez Source Type: research

Pediatric stroke codes need to grow  up
Previously in The Journal, Harrar et al (J Pediatr 2020;216:136-41.e6. DOI: https://doi.org/10.1016/j.jpeds.2019.09.027) reported that the use of a pediatric stroke code system could decrease median time to just over an hour from emergency department arrival to neuroimaging. Timely diagnosis is prerequisite in order to initiate interventional therapies quickly and improve neurologic outcomes. Time is brain! However, this prior study analyzed data from only one advanced, tertiary children's hospital.
Source: The Journal of Pediatrics - February 22, 2022 Category: Pediatrics Authors: Paul G. Fisher Tags: The Editors' Perspectives Source Type: research

Mesenchymal stem cell therapy in perinatal arterial ischemic stroke: systematic review of preclinical studies
CONCLUSION: MSCs appear to improve sensorimotor and cognitive performance in PAIS-injured animals; however, the certainty of the evidence is low. Registration of the protocol of preclinical studies, appropriate sample size calculation, rigorous randomization, and reporting of the data on animal sex and survival are warranted. PROSPERO registration number: CRD42021239642.IMPACT: This is the first systematic review and meta-analysis of preclinical studies investigating the effects of MSCs in an experimental model of PAIS. MSCs appear to improve sensorimotor and cognitive performance in PAIS-injured neonatal animals. The cert...
Source: Pediatric Research - July 29, 2022 Category: Pediatrics Authors: Verena Lehnerer Anna Roidl Olga Romantsik Raphael Guzman Sven Wellmann Matteo Bruschettini Source Type: research

Cardiac Preload Responsiveness in Children With Cardiovascular Dysfunction or Dilated Cardiomyopathy: A Multicenter Observational Study*
Conclusions: This study provides “normal” values for global end-diastolic volume index and limits of cardiac preload responsiveness in pediatric patients with cardiovascular dysfunction and dilated cardiomyopathy: 1.33 times normal global end-diastolic volume index represents the upper limit of patent cardiac preload responsiveness, with the highest expected responsiveness being below 0.67 times normal global end-diastolic volume index. The maximum response of the Frank-Starling relationship and therefore the level of no additional preload reserve is 1.33 to 1.51 times normal global end-diastolic volume index. Above 1....
Source: Pediatric Critical Care Medicine - January 1, 2015 Category: Pediatrics Tags: Cardiac Intensive Care Source Type: research

Cerebral vasculopathy in pediatric sickle-cell anemia.
Abstract In children with sickle-cell anemia, cerebral vasculopathy is a frequent and severe complication. It is attributed not only to erythrocyte sickling but also to multiple physiological modifications associated with sickle-cell anemia: platelet and leukocyte activation, endothelial injury and remodeling, coagulation activation, hemolysis and subsequent chronic inflammation, impaired vasomotricity, etc. Intracranial large-vessel remodeling leads to clinical cerebral infarction, whereas microvascular injury and impaired vasoreactivity lead to so-called silent infarcts, which are actually associated with impair...
Source: Archives de Pediatrie - March 12, 2014 Category: Pediatrics Authors: Kossorotoff M, Grevent D, de Montalembert M Tags: Arch Pediatr Source Type: research

Evaluation of hemodynamics in healthy term neonates using ultrasonic cardiac output monitor
ConclusionsCompared to previous studies, we expanded measurements to longer time-points and we analyzed the impact of commonly used clinical variables on hemodynamics during transition phase thus making our data clinically applicable in daily routine. We calculate reference values for each population, which can be of clinical relevance for quick bedside evaluation in neonatal intensive care unit.
Source: Italian Journal of Pediatrics - August 4, 2020 Category: Pediatrics Source Type: research

Brain-derived neurotrophic factor and neuroimaging in pediatric patients with sickle cell disease
CONCLUSION: Serum BDNF levels were higher in sickle disease patients who had abnormal transcranial Doppler. BDNF had a significant diagnostic ability in the detection of SCD complications.IMPACT: Silent stroke is a very serious complication in children with sickle cell disease, so regular follow up should be every six months. BDNF is considered a potential biomarker for stroke risk prediction in patients unable to receive TCD.PMID:36774398 | DOI:10.1038/s41390-023-02513-5
Source: Pediatric Research - February 11, 2023 Category: Pediatrics Authors: Asmaa A Mahmoud Sameh A Abd El Naby Ahmed S Abdelgawad Marwa Sabry Rizq Nahla M S Abd El Hady Source Type: research

Can Patent Foramen Ovales Cause Problems?
Discussion During fetal development, the heart primum and secundum septa grow and overlap leaving a small but important channel between the two atria. The foramen ovale is a flap valve moving blood from the right atrium into the left atrium directly and bypassing the high pressure pulmonary system. After birth and breathing air, the neonate’s lungs open up and the pulmonary vascular resistance decreases. The left atrium now has a relatively higher pressure than the right atria, and therefore pressure on the flap valve closes the foramen ovale. Usually within 6-12 months, the fusion of the primum and secundum of the f...
Source: PediatricEducation.org - July 24, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news