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Total 3873 results found since Jan 2013.
Epidemiologic features and risk factors of sepsis in ischemic stroke patients admitted to intensive care: A prospective cohort study
ConclusionsThis study showed that ICU patients with severe ischemic stroke were more susceptible to sepsis during the hospital course.
Source: Journal of Clinical Neuroscience - September 20, 2019 Category: Neuroscience Source Type: research
Two Novel SNPs in the PLCL2 Gene Associated with Large Artery Atherosclerotic Stroke Identified by Fine-Mapping
AbstractA genome-wide association study (GWAS) reported that the single nucleotide polymorphism (SNP) rs4618210 in thePLCL2 gene is related to myocardial infarction (MI) in the Japanese population, but no study has examined the correlation ofPLCL2 with ischemic stroke (IS). The present study was designed to investigate whether the genetic variation inPLCL2 is associated with large artery atherosclerotic (LAA) stroke in a Han Chinese population. Tagging SNPs (tSNPs) of thePLCL2 gene were determined by a fine-mapping strategy and were genotyped by improved multiplex ligation detection reaction (iMLDR) technology in 669 LAA s...
Source: Journal of Molecular Neuroscience - January 21, 2020 Category: Neuroscience Source Type: research
Cardiac Imaging After Ischemic Stroke or Transient Ischemic Attack
This article summarizes the latest research on this topic and provides an approach to clinical practice to use cardiac imaging after stroke.Recent FindingsEchocardiography remains the primary imaging method for cardiac work-up after stroke. Recent echocardiography studies further demonstrated promising results regarding the prediction of non-permanent atrial fibrillation after ischemic stroke. Cardiac magnetic resonance imaging and computed tomography have been tested for their diagnostic value, in particular in patients with cryptogenic stroke, and can be considered as second line methods, providing complementary informat...
Source: Current Neurology and Neuroscience Reports - June 29, 2020 Category: Neuroscience Source Type: research
A Qualitative Inquiry Into Patient Reported Factors That Influence Time From Stroke Symptom Onset to Hospitalization
CONCLUSION: Response to stroke onset may be driven by perceptions of symptom severity and emotional response rather than the ability to correctly identify symptoms. Stroke education should include the information that new stroke symptoms may be different from the old ones because different parts of the brain may be affected.
Source: Journal of Neuroscience Nursing - January 9, 2021 Category: Neuroscience Tags: Articles Source Type: research
Hyaluronidase inhibition accelerates functional recovery from stroke in the mouse brain
Hyaluronic acid (HA) is the main component of the brain extracellular matrix (ECM). During stroke, a massive breakdown of HA occurs (including perineuronal net ‐associated HA), however, the mechanism of this phenomenon remains unclear. We hypothesized that stroke up‐regulates the expression of HA metabolism‐associated enzymes and increases HA synthesis/degradation. We observed increased expression of HA‐degrading hyaluronidases and hexosaminidases, as well as HA synthases. Immunofluorescence studies revealed predominating astrocytic origin of the enzymes. Moreover, we found that inhibiting hyaluronidases with Vcpal...
Source: Journal of Neurochemistry - January 5, 2021 Category: Neuroscience Authors: Anna Katarzyna Greda,
Dorota Nowicka Tags: ORIGINAL ARTICLE Source Type: research
Inflammation-Related circRNA Polymorphism and Ischemic Stroke Prognosis
AbstractCircRNAs belong to a novel class of noncoding RNAs that are generated by exons of genes by alternative mRNA splicing and involved in pathophysiological processes of ischemic stroke by regulating neuro-inflammation. A total of 982 patients were enrolled in our study for stroke recovery analysis. The aim of our study was to first explore the association between the inflammation-related circRNA polymorphism and functional outcome 3 months after ischemic stroke by using multivariate logistic regression model. Next, we further investigated the role of circRNA polymorphism in predicting stroke recurrence by using Cox p...
Source: Journal of Molecular Neuroscience - July 17, 2021 Category: Neuroscience Source Type: research
Stroke-Specific Refinements to Naylor's Transitional Care Model to Address the Storm of Uncertainty and Unmet Survivor and Caregiver Needs
CONCLUSION: Unmet needs identified by SSs and CGs were used to extend NTCM specific to the stroke population and to develop the Recommendations and Exemplars for Stroke Specific Comprehensive Transitional Care Delivery (see Supplementary Digital Content, available at http://links.lww.com/JNN/A385). Researchers and practitioners can use the findings to develop and deliver more comprehensive TC to SSs and CGs.
Source: Journal of Neuroscience Nursing - January 15, 2022 Category: Neuroscience Tags: Articles Source Type: research
Symptoms and pattern of symptom propagation in incipient ischemic stroke and migraine aura
ConclusionThere is a significant overlap in the clinical presentation of stroke and migraine aura. In particular, a substantial proportion of patients in one group had symptoms that are traditionally attributed to the other group. This study highlights the similarities and differences between symptoms of ischemic stroke and migraine aura and challenges our reasoning in daily clinical practice.
Source: Frontiers in Human Neuroscience - January 13, 2023 Category: Neuroscience Source Type: research
Association of serum uric acid to lymphocyte ratio, a novel inflammatory biomarker, with risk of stroke: A prospective cohort study
CONCLUSIONS: ULR was significantly associated with the risk of HS, but not with IS. Systolic blood pressure, diastolic blood pressure and estimated glomerular filtration rate were potential mediators for the association.PMID:36650955 | DOI:10.1111/cns.14094
Source: CNS Neuroscience and Therapeutics - January 18, 2023 Category: Neuroscience Authors: Xue Tian Penglian Wang Shuohua Chen Yijun Zhang Xiaoli Zhang Qin Xu Yanxia Luo Shouling Wu Anxin Wang Source Type: research
Impact of the COVID-19 pandemic on acute stroke care: An analysis of the 24-month data from a comprehensive stroke center in Shanghai, China
CONCLUSIONS: During the 24 months of COVID-19, a prolongation of stroke onset to hospital arrival and to intravenous rt-PA administration times were noted. Meanwhile, acute stroke patients needed to stay in the ED for a longer time before hospitalization. Educational system support and process optimization should be pursued in order to acquire timely delivery of stroke care during the pandemic.PMID:36890633 | DOI:10.1111/cns.14148
Source: CNS Neuroscience and Therapeutics - March 8, 2023 Category: Neuroscience Authors: Qimin Hu Yiming Hu Yue Gu Xiaoyan Song Yijue Shen Haiyan Lu Li Zhang Peifeng Liu Guodong Wang Chunni Guo Kan Fang Qiaoshu Wang Source Type: research
Trends in NLRP3 inflammasome research in ischemic stroke from 2011 to 2022: A bibliometric analysis
CONCLUSION: This study is a scientometric study utilizing quantitative and qualitative methods to comprehensively review the publications on NLRP3 in ischemic stroke. This information provides a reference for scholars to further study NLRP3 in ischemic stroke.PMID:37088947 | DOI:10.1111/cns.14232
Source: CNS Neuroscience and Therapeutics - April 23, 2023 Category: Neuroscience Authors: Hua Zhu Yonggang Zhang Shi Feng Yina Li Yingze Ye Zhihong Jian Xiaoxing Xiong Lijuan Gu Source Type: research
