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Total 2417 results found since Jan 2013.

P-008 on intent to treat adapt technique for 201 cases of anterior circulation acute ischemic stroke
We report our single center experience results of endovascular treatment of anterior circulation of ischemic stroke by the technique of direct aspiration.MethodsBetween September 2013 to March 2015 we reviewed the data of 201 patients presenting with large vessels anterior circulation occlusion for which the ADAPT technique was utilized in first intention and was associated with stentriever technique when necessary. Procedural and clinical data were collected for analysis. An univariate analysis of the following factors: Age, prior antiplatelet or anticoagulative therapy, localisation of the occlusion, an intravenous throm...
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Blanc, R., Redjem, H., Bartolini, B., Ciccio, G., Smajda, S., Taylor, G., Lamrabet, S., Paraschakis, P., Piotin, M. Tags: SNIS 12th Annual Meeting Oral Poster Abstracts Source Type: research

Noninvasive pulse pressure variation and stroke volume variation to predict fluid responsiveness at multiple thresholds: a prospective observational study.
CONCLUSION: Noninvasive PPV and SVV measurements allow an acceptable FR prediction, although the reliability of both variables is dependent on the intended increase in SVI, which improves substantially with concomitant smaller grey zones at higher ↑SVI thresholds. PMID: 26335905 [PubMed - as supplied by publisher]
Source: Canadian Journal of Anaesthesia - September 3, 2015 Category: Anesthesiology Authors: Vos JJ, Poterman M, Salm PP, Van Amsterdam K, Struys MM, Scheeren TW, Kalmar AF Tags: Can J Anaesth Source Type: research

The thick left ventricular wall of the giraffe heart normalises wall tension, but limits stroke volume and cardiac output RESEARCH ARTICLE
Morten Smerup, Mads Damkjaer, Emil Brondum, Ulrik T. Baandrup, Steen Buus Kristiansen, Hans Nygaard, Christian Aalkjaer, Cathrine Sauer, Rasmus Buchanan, Mads Frost Bertelsen, Kristine Ostergaard, Carsten Grondahl, Geoffrey Candy, J. Michael Hasenkam, Niels H. Secher, Peter Bie, and Tobias WangGiraffes – the tallest extant animals on Earth – are renowned for their high central arterial blood pressure, which is necessary to secure brain perfusion. The pressure which may exceed 300 mmHg has historically been attributed to an exceptionally large heart. Recently, this has been refuted by several studies demonstrati...
Source: Journal of Experimental Biology - December 7, 2015 Category: Biology Authors: Smerup, M., Damkjaer, M., Brondum, E., Baandrup, U. T., Kristiansen, S. B., Nygaard, H., Aalkjaer, C., Sauer, C., Buchanan, R., Bertelsen, M. F., Ostergaard, K., Grondahl, C., Candy, G., Hasenkam, J. M., Secher, N. H., Bie, P., Wang, T. Tags: RESEARCH ARTICLE Source Type: research

Epidural Electrical Stimulation for Stroke Rehabilitation: Results of the Prospective, Multicenter, Randomized, Single-Blinded Everest Trial
Conclusions. The primary analysis pertaining to efficacy of EECS during upper limb motor rehabilitation in chronic stroke patients was negative at 4 weeks postrehabilitation. A better treatment response was observed in a subset of patients eliciting stimulation induced upper limb movements during motor threshold assessments performed prior to each rehabilitation session. Post hoc comparisons indicated treatment effect differences at 24 weeks, with the control group showing significant decline in the combined primary outcome measure relative to the investigational group. These results have the potential to inform future chr...
Source: Neurorehabilitation and Neural Repair - January 27, 2016 Category: Neurology Authors: Levy, R. M., Harvey, R. L., Kissela, B. M., Winstein, C. J., Lutsep, H. L., Parrish, T. B., Cramer, S. C., Venkatesan, L. Tags: Clinical Research Articles Source Type: research

The thick left ventricular wall of the giraffe heart normalises wall tension, but limits stroke volume and cardiac output RESEARCH ARTICLE
Morten Smerup, Mads Damkjaer, Emil Brondum, Ulrik T. Baandrup, Steen Buus Kristiansen, Hans Nygaard, Jonas Funder, Christian Aalkjaer, Cathrine Sauer, Rasmus Buchanan, Mads Frost Bertelsen, Kristine Ostergaard, Carsten Grondahl, Geoffrey Candy, J. Michael Hasenkam, Niels H. Secher, Peter Bie, and Tobias Wang Giraffes – the tallest extant animals on Earth – are renowned for their high central arterial blood pressure, which is necessary to secure brain perfusion. Arterial pressure may exceed 300 mmHg and has historically been attributed to an exceptionally large heart. Recently, this has been refuted by seve...
Source: Journal of Experimental Biology - February 3, 2016 Category: Biology Authors: Smerup, M., Damkjaer, M., Brondum, E., Baandrup, U. T., Kristiansen, S. B., Nygaard, H., Funder, J., Aalkjaer, C., Sauer, C., Buchanan, R., Bertelsen, M. F., Ostergaard, K., Grondahl, C., Candy, G., Hasenkam, J. M., Secher, N. H., Bie, P., Wang, T. Tags: RESEARCH ARTICLE Source Type: research

Effect of fluid loading with normal saline and 6% hydroxyethyl starch on stroke volume variability and left ventricular volume
Conclusion: Administration of colloid and crystalloid induced similar responses in SVV. A higher plasma-expanding effect of HES compared to normal saline was demonstrated by the significant increase in LVEDV.Keywords: colloid–crystalloid controversy, fluid responsiveness, three-dimensional transesophageal echocardiography (3D-TEE)
Source: International Journal of General Medicine - September 29, 2015 Category: Journals (General) Tags: International Journal of General Medicine Source Type: research

In vivo bioimpedance changes during haemorrhagic and ischaemic stroke in rats: towards 3D stroke imaging using electrical impedance tomography
Electrical impedance tomography (EIT) could be used as a portable non-invasive means to image the development of ischaemic stroke or haemorrhage. The purpose of this study was to examine if this was possible using time difference imaging, in the anesthetised rat using 40 spring-loaded scalp electrodes with applied constant currents of 50–150 μ A at 2 kHz. Impedance changes in the largest 10% of electrode combinations were  −12.8%  ±  12.0% over the first 10 min for haemorrhage and  +46.1%  ±  37.2% over one hour for ischaemic stroke (mean  ±  SD, n   =  7 in each gro...
Source: Physiological Measurement - May 18, 2016 Category: Physiology Authors: T Dowrick, C Blochet and D Holder Source Type: research

Improved cardiac filling facilitates the postprandial elevation of stroke volume in Python regius RESEARCH ARTICLE
Sanne Enok, Gabriella Leite, Cleo Leite, Hans Gesser, Michael S. Hedrick, and Tobias WangTo accommodate the pronounced metabolic response to digestion, pythons increase both heart rate and elevate stroke volume, where the latter has been ascribed to a massive and fast cardiac hypertrophy. However, numerous recent studies show that heart mass rarely increases even upon ingestion of large meals, and we therefore explored the possibility that a rise in mean circulatory filling pressure (MCFP) serves to elevate venous pressure and cardiac filling during digestion. To this end, we measured blood flows and pressures in anaesthet...
Source: Journal of Experimental Biology - July 20, 2016 Category: Biology Authors: Enok, S., Leite, G., Leite, C., Gesser, H., Hedrick, M. S., Wang, T. Tags: RESEARCH ARTICLE Source Type: research

Effects of Workflow Optimization in Endovascularly Treated Stroke Patients – A Pre-Post Effectiveness Study
This study analyzes the effect of optimized workflow on periprocedural timings and its potential influence on clinical outcome. Data were extracted from a prospectively maintained university hospital stroke database. The standard ope rating procedure was established in February 2014. Of the 368 acute stroke patients undergoing endovascular treatment between 2008 and 2015, 278 patients were treated prior to and 90 after process optimization. Outcome measures were periprocedural time intervals and residual functional impairment. A fter implementation of the SOP, time from symptom onset to reperfusion was significantly reduce...
Source: PLoS One - December 29, 2016 Category: Biomedical Science Authors: Katharina Schregel Source Type: research

Anesthetic Neuroprotection in Experimental Stroke in Rodents A Systematic Review and Meta-analysis
Background Patients undergoing endovascular therapy for acute ischemic stroke may require general anesthesia to undergo the procedure. At present, there is little clinical evidence to guide the choice of anesthetic in this acute setting. The clinical implications of experimental studies demonstrating anesthetic neuroprotection are poorly understood. Here, the authors evaluated the impact of anesthetic treatment on neurologic outcome in experimental stroke.Methods Controlled studies of anesthetics in stroke using the filament occlusion model were identified in electronic databases up to December 15, 2015. The primary outcom...
Source: Anesthesiology - March 14, 2017 Category: Anesthesiology Source Type: research

Management of acute ischemic stroke due to tandem occlusion: should endovascular recanalization of the extracranial or intracranial occlusive lesion be done first?
CONCLUSIONS Tandem occlusions present treatment challenges, but high recanalization rates were possible in the present series using acute carotid artery stenting and mechanical thrombectomy concurrently. Proximal-to-distal and aspiration approaches were most commonly used because they were safe, efficacious, and feasible. Further study in the setting of a randomized controlled trial is needed to determine the best sequence for the treatment approach and the best technology for tandem occlusion. PMID: 28366065 [PubMed - in process]
Source: Neurosurgical Focus - April 1, 2017 Category: Neurosurgery Authors: Rangel-Castilla L, Rajah GB, Shakir HJ, Shallwani H, Gandhi S, Davies JM, Snyder KV, Levy EI, Siddiqui AH Tags: Neurosurg Focus Source Type: research

Stroke Volume Variation and Pulse Pressure Variation Are Not Useful for Predicting Fluid Responsiveness in Thoracic Surgery.
CONCLUSIONS: Dynamic preload indicators are not useful for predicting fluid responsiveness in VATS or open thoracic surgery. PMID: 28504996 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - May 11, 2017 Category: Anesthesiology Authors: Jeong DM, Ahn HJ, Park HW, Yang M, Kim JA, Park J Tags: Anesth Analg Source Type: research

Impact of Anesthesia on the Outcome of Acute Ischemic Stroke after Endovascular Treatment with the Solitaire Stent Retriever INTERVENTIONAL
CONCLUSIONS: In this single-center study, the anesthetic management during stent retriever thrombectomy with general anesthesia or conscious sedation had no impact on the outcome of patients with large-vessel occlusion in the anterior circulation.
Source: American Journal of Neuroradiology - July 12, 2017 Category: Radiology Authors: Slezak, A., Kurmann, R., Oppliger, L., Broeg-Morvay, A., Gralla, J., Schroth, G., Mattle, H. P., Arnold, M., Fischer, U., Jung, S., Greif, R., Neff, F., Mordasini, P., Mono, M.- L. Tags: INTERVENTIONAL Source Type: research