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Making AI Matter in Healthcare
Healthcare is just as prone to fall victim to hype and irrational exuberance as any other complex industry. And the more revolutionary the promise, the more outrageous the overstatements could be. Artificial intelligence has certainly been one of those "next big things" for some time in healthcare. Whether branded as "big data and analytics" or "automated clinical decision support," the results of technology-assisted care, especially in non-clinical and non-emergent settings, have been uneven at best. But a new report indicates AI's time in healthcare is nigh, and technology and policy pioneers are doing their best to ensu...
Source: MDDI - March 9, 2018 Category: Medical Devices Authors: Greg Goth Tags: Software Digital Health Source Type: news

The current and potential health benefits of the National Health Service Health Check cardiovascular disease prevention programme in England: A microsimulation study
ConclusionsOur model indicates that the current NHS Health Check programme is contributing to improvements in health and reducing health inequalities. Feasible changes in the organisation of the programme could result in more than a 3-fold increase in health benefits.
Source: PLoS Medicine - March 6, 2018 Category: Internal Medicine Authors: Oliver T. Mytton Source Type: research

Sodium-glucose cotransporter 2 inhibitors and ischemic stroke.
CONCLUSION: Despite the multiple pleiotropic effects of SGLT-2 inhibitors, these agents do not appear to affect stroke risk. Ongoing large trials with longer follow-up will evaluate whether the pleiotropic effects of this class will translate into benefits in ischemic stroke prevention. PMID: 29412119 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Disorders Drug Targets - February 9, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Perioperative strokes following combined coronary artery bypass grafting and carotid endarterectomy: A nationwide perspective
Conclusion: A strong association was found to exist between perioperative stroke and in-hospital mortality and morbidity after combined CABG and CEA. CEA procedures are thought to mitigate the high stroke rate of 3-5% post-CABG, but our study found that combined procedures exhibit a similar stroke risk undercutting their effectiveness. Further investigative studies on combined CABG+CEA are needed to assess risk-stratification for better patient selection and examine other preventative strategies to minimize the risk of ischemic strokes.
Source: Neurology India - January 11, 2018 Category: Neurology Authors: Reshmi Udesh Hannah Cheng Amol Mehta Parthasarathy D Thirumala Source Type: research

Case Study: Physical Capacity and Nutritional Status Before and After a Single-Handed Yacht Race.
Abstract During solitary sailing the sailor is exposed to sleep deprivation and difficulties in consuming regular meals. Sailor weight loss is often reported. In the present case study we describe changes in the physical capacity and the nutritional status of an athlete attempting a single-handed yacht race around the globe. An Italian male ocean racer (GM) asked for our help to reach an optimum level of physical and nutritional preparation. We planned his diet after assessing his anthropometric parameters and body composition as well as his usual energy intake and nutritional expenditure. The diet consisted in 12...
Source: International Journal of Sport Nutrition and Exercise Metabolism - December 18, 2017 Category: Sports Medicine Authors: Ghiani G, Magnani S, Doneddu A, Sainas G, Pinna V, Caboi M, Palazzolo G, Tocco F, Crisafulli A Tags: Int J Sport Nutr Exerc Metab Source Type: research

Weight Loss in Italy?
One of the women I work with wanted to know about the new diet drug called Belviq. The FDA is always approving a new “miracle” weight-loss pill, only to recall it a few years later. To date, at least 34 diet drugs have been taken off the market. Diet pills cause all kinds of problems — heart attack, stroke and psychiatric disorders. And Belviq isn’t any different. Some of its side effects include suicidal thoughts, a racing heartbeat, hallucinations and more… The European Union banned Belviq. The reason? It causes cancer in animals.  And here’s the real irony… Clinical trials found ...
Source: Al Sears, MD Natural Remedies - October 19, 2017 Category: Complementary Medicine Authors: Cathy Card Tags: Anti-Aging Source Type: news

Adipose tissue and metabolic and inflammatory responses to stroke are altered in obese mice RESEARCH ARTICLE
ABSTRACT Obesity is an independent risk factor for stroke, although several clinical studies have reported that obesity improves stroke outcome. Obesity is hypothesised to aid recovery by protecting against post-stroke catabolism. We therefore assessed whether obese mice had an altered metabolic and inflammatory response to stroke. Obese ob/ob mice underwent a 20-min middle cerebral artery occlusion and 24-h reperfusion. Lipid metabolism and expression of inflammatory cytokines were assessed in the plasma, liver and adipose tissue. The obese-specific metabolic response to stroke was assessed in plasma using non-targeted ul...
Source: DMM Disease Models and Mechanisms - October 9, 2017 Category: Biomedical Science Authors: Haley, M. J., Mullard, G., Hollywood, K. A., Cooper, G. J., Dunn, W. B., Lawrence, C. B. Tags: RESEARCH ARTICLE Source Type: research

Delayed 2-hour post-stroke administration of R18 and NA-1 (TAT-NR2B9c) peptides after permanent and/or transient middle cerebral artery occlusion in the rat.
Abstract Following positive results with the poly-arginine peptide R18 when administered intravenously 30 or 60minutes after permanent and/or transient middle cerebral artery occlusion (MCAO; 90min) in the rat, we examined the effectiveness of the peptide when administered 2hours after MCAO. R18 was administered intravenously (1000nmol/kg via jugular vein) after permanent MCAO or a transient 3-hour MCAO or when administered intra-arterially (100nmol/kg via internal carotid artery) immediately after reperfusion following a transient 2-hour MCAO. In the transient MCAO studies, the neuroprotective NA-1 peptide was us...
Source: Brain Research Bulletin - September 27, 2017 Category: Neurology Authors: Milani D, Cross JL, Anderton RS, Blacker DJ, Knuckey NW, Meloni BP Tags: Brain Res Bull Source Type: research

Association between Exposure to p,p ′-DDT and Its Metabolite p,p′-DDE with Obesity: Integrated Systematic Review and Meta-Analysis
Conclusions: We classified p,p′-DDT and p,p′-DDE as “presumed” to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary in vivo evidence, and a moderate level of supporting evidence from in vivo and in vitro studies. https://doi.org/10.1289/EHP527 Received: 17 May 2016 Revised: 04 May 2017 Accepted: 09 May 2017 Published: 18 September 2017 Please address correspondence to M.A. La Merrill, Dept. of Environmental Toxicology, University of California, Davis, 1 Shields Ave., 4245 Meyer Hall, Davis, CA 95616-5270 USA. Telephone: (530) 754-7254. Email: mlamerrill...
Source: EHP Research - September 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

Clinical Presentation of Multiple Cerebral Emboli and Central Retinal Artery Occlusion (CRAO) as signs of Cardiac Myxoma
We present a patient whose history of cerebral emboli and central retinal artery occlusion (CRAO) led to a diagnosis of cardiac myxoma. Neuroimaging studies showed multiple infarcts in the region of the left middle and anterior cerebral arteries. Ophthalmic examination showed gross retinal pallor compatible with left central retinal artery occlusion (CRAO). The etiology of stroke was investigated by performing trans-thoracic echocardiography, which showed a mass in the left atrium compatible with cardiac myxoma. Complete removal of the cardiac tumor was performed by open-heart surgery. Fortunately, after a period of rehabi...
Source: Saudi Journal of Ophthalmology - September 15, 2017 Category: Opthalmology Source Type: research

Genetic Inhibition of Receptor Interacting Protein Kinase-1 Reduces Cell Death and Improves Functional Outcome After Intracerebral Hemorrhage in Mice Basic Sciences
Conclusions—The data show that the kinase domain of RIPK1 is a disease driver of ICH, mediating both acute cell death and functional outcome, and support development of RIPK1 inhibitors as therapeutic agents for human ICH.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Sevda Lule, Limin Wu, Lauren M. McAllister, William J. Edmiston III, Joon Yong Chung, Emily Levy, Yi Zheng, Peter J. Gough, John Bertin, Alexei Degterev, Eng H. Lo, Michael J. Whalen Tags: Basic Science Research, Genetically Altered and Transgenic Models, Intracranial Hemorrhage Original Contributions Source Type: research

HealthWatch: How Sweeteners And Sleep Influence Weight Gain
BOSTON (CBS) – A new report shows inadequate sleep could be making you fat. Researchers in the United Kingdom found that adults who slept an average of 6 hours a night weighed more and had a waist circumference about an inch larger than those getting 9 hours of sleep a night. They also had lower levels of HDL or “good” cholesterol. While most of us do not get 9 hours of sleep a night, we should all strive to get at least 7 to 8. That’s because there is growing evidence that chronic sleep deprivation can increase our risk of obesity and metabolic disorders like diabetes and high cholesterol, which can lead to...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - August 2, 2017 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health Local News artificial sweeteners Dr. Mallika Marshall Health Watch Weight Loss Source Type: news

Benefits of artificial sweeteners unclear
Conclusion The study authors suggest artificial sweeteners may not aid weight loss, despite marketing claims to the contrary, and could actually increase the risk of type 2 diabetes. However, the results need to be treated with caution, as this review had numerous limitations: The randomised controlled trials had great variability and few participants, increasing the possibility of the results occurring by chance. They were also judged to be at a high risk of bias – for example, the participants could not be blinded to the intervention, and adherence (drop-out) rates were not provided. We do not know whether there w...
Source: NHS News Feed - July 19, 2017 Category: Consumer Health News Tags: Food/diet Obesity Source Type: news

Science: Sugar substitute effects not so sweet
Not so sweet. Switching out sucralose or other artificial sweeteners for sugar won ’t help you lose weight and may cause future health problems, researchers who reviewed multiple scientific studies on the topic said. Researchers found a link between consuming artificial sweeteners and higher risks of weight gain, Type 2 diabetes, hypertension, stroke and heart disease, Live Sci ence reported, while weight loss results were minimal. The purpose of the review was to determine the effects of non-nutritive…
Source: bizjournals.com Health Care:Physician Practices headlines - July 17, 2017 Category: American Health Authors: Anne Stych Source Type: news

Cardiac myxoma: clinical characteristics, surgical intervention, intra-operative challenges and outcome.
CONCLUSION: The success rate after surgical removal of cardiac myxoma in this study was substantial and complications were rare. PMID: 28762298 [PubMed - as supplied by publisher]
Source: Perfusion - July 1, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Abu Abeeleh M, Saleh S, Alhaddad E, Alsmady M, Alshehabat M, Bani Ismail Z, Massad I, Bani Hani A, Abu Halaweh S Tags: Perfusion Source Type: research