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Long-term consumption of fermented rooibos herbal tea offers neuroprotection against ischemic brain injury in rats.
In this study, we investigated the effects of long-term consumption of fermented rooibos herbal tea (FRHT) on ischemia/reperfusion (I/R)-induced brain injury in adult male Wistar rats. FRHT was administered to the animals ad libitum for 7 weeks prior to the induction of ischemic injury via a 20-minute bilateral occlusion of the common carotid arteries (BCCAO) followed by reperfusion for 24, 96 and 168 hours respectively. Neurobehavioural deficits, brain oedema, blood-brain barrier (BBB) damage, apoptosis, lipid peroxidation and total antioxidant capacity were subsequently evaluated using standard methods. Our results showe...
Source: Acta Neurobiologiae Experimentalis - April 6, 2017 Category: Neurology Authors: Akinrinmade O, Omoruyi S, Dietrich D, Ekpo O Tags: Acta Neurobiol Exp (Wars) Source Type: research

Clinacanthus nutans Protects Cortical Neurons Against Hypoxia-Induced Toxicity by Downregulating HDAC1/6
This study further opens a new avenue for the use of herbal medicines to regulate epigenetic control of brain injury.
Source: NeuroMolecular Medicine - May 9, 2016 Category: Neurology Source Type: research

MLC901 Favors Angiogenesis and Associated Recovery after Ischemic Stroke in Mice
Conclusions: These results demonstrate therapeutic properties of MLC901, in addition to those previously described, in stimulating revascularization, neuroprotection and repair of the neurovascular unit after ischemic stroke.Cerebrovasc Dis 2016;42:139-154
Source: Cerebrovascular Diseases - April 21, 2016 Category: Neurology Source Type: research

Ginsenoside Rd Is Efficacious Against Acute Ischemic Stroke by Suppressing Microglial Proteasome-Mediated Inflammation
In this study, we conducted a pooled analysis of the data from 199 patients with acute ischemic stroke in the first trial and 390 in the second to reanalyze the efficacy and safety of Rd. Moreover, animal stroke models were carried out to explore the possible molecular mechanisms underlying Rd neuroprotection. The pooled analysis showed that compared with placebo group, Rd could improve patients’ disability as assessed by modified Rankin Scale (mRS) score on day 90 post-stroke and reduce neurologic deficits on day 15 or day 90 post-stroke as assessed by NIH Stroke Scale (NIHSS) and Barthel Index (BI) scores. For neuropro...
Source: Molecular Neurobiology - June 17, 2015 Category: Neurology Source Type: research

The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats
Ischemic stroke is a major cause of death and disability all over the world. Ischemic stroke results from a temporary or permanent reduction of cerebral blood flow that leads to functional and structural damage in different brain regions. Despite decades of intense research, the beneficial treatment of stroke remains limited. In light of this, the search for effective means ameliorating cerebral ischemia-reperfusion injury (CIRI) is one of the major problems of experimental medicine and biology. Recently, the 5-Lipoxygenase (5-LO, a key enzyme metabolizing arachidonic acid to produce leukotrienes) inhibitors have been show...
Source: Behavioral and Brain Functions - April 18, 2015 Category: Neurology Authors: Guojuan LiangBin ShiWeinan LuoJunqing Yang Source Type: research

Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral ischemia/reperfusion rats
Abstract: Isoflavone calycosin is a typical phytoestrogen extracted from Chinese medical herb Radix Astragali. It has been reported that estrogens could provide neuroprotective effects, and dietary intake of phytoestrogens could reduce stroke injury in cerebral ischemia/reperfusion (I/R) animal models. In the present study, we investigate the molecular mechanisms underlying the neuroprotective effects of calycosin on middle cerebral artery occlusion (MCAO) rats. Focal cerebral ischemia was induced in male rats by MCAO, neurological deficits and brain edema was evaluated after 24h of reperfusion. The results shown calycosin...
Source: Journal of the Neurological Sciences - February 18, 2014 Category: Neurology Authors: Yong Wang, Xianhong Dong, Zhengzhao Li, Wenbo Wang, Jing Tian, Jian Chen Tags: Original Articles Source Type: research

Effect of lavender oil (Lavandula angustifolia) on cerebral edema and its possible mechanisms in an experimental model of stroke.
Abstract Lavender belongs to the family Labiatae and has a variety of cosmetic uses as well as therapeutic purposes in herbal medicine. The present study was conducted to evaluate the protective effect of lavender oil against brain edema and its possible mechanisms in an experimental model of stroke. Under Laser-Doppler Flowmetry, focal cerebral ischemia was induced by the transient occlusion of the middle cerebral artery for 1h in rats. Lavender oil (100, 200, and 400mg/kg ip (and/or vehicle was injected at the onset of ischemia. Infarct size, cerebral edema, functional outcome, and oxidative stress biomarkers we...
Source: Brain Research - December 30, 2013 Category: Neurology Authors: Vakili A, Sharifat S, Akhavan MM, Bandegi AR Tags: Brain Res Source Type: research

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