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Total 496 results found since Jan 2013.
Recent Advances in Chinese Herbal Medicine for Cerebral Ischemic Reperfusion Injury
Cerebral ischemic reperfusion injury (CI/RI) is a critical factor that leads to a poor prognosis in patients with ischemic stroke. It is an extremely complicated pathological process that is clinically characterized by high rates of disability and mortality. Current available treatments for CI/RI, including mechanical and drug therapies, are often accompanied by significant side effects. Therefore, it is necessary to discovery new strategies for treating CI/RI. Many studies confirm that Chinese herbal medicine (CHM) was used as a potential drug for treatment of CI/RI with the advantages of abundant resources, good efficacy...
Source: Frontiers in Pharmacology - January 17, 2022 Category: Drugs & Pharmacology Source Type: research
Neuroprotective Effect of Daidzein Extracted From Pueraria lobate Radix in a Stroke Model Via the Akt/mTOR/BDNF Channel
Daidzein is a plant isoflavonoid primarily isolated from Pueraria lobate Radix as the dry root of P. lobata (Wild.) Ohwi, have long been used as nutraceutical and medicinal herb in China. Despite the report that daidzein can prevent neuronal damage and improve outcome in experimental stroke, the mechanisms of this neuroprotective action have been not fully elucidated. The aim of this study was to determine whether the daidzein elicits beneficial actions in a stroke model, namely, cerebral ischemia/reperfusion (I/R) injury, and to reveal the underlying neuroprotective mechanisms associated with the regulation of Akt/mTOR/BD...
Source: Frontiers in Pharmacology - January 14, 2022 Category: Drugs & Pharmacology Source Type: research
Network pharmacology and < em > in vitro < /em > experimental verification to explore the mechanism of Sanhua decoction in the treatment of ischaemic stroke
CONCLUSIONS: This study suggests that SHD protects against cerebral ischaemic injury via regulation of the PI3K/Akt/CREB1 and TNF pathways.PMID:34985385 | PMC:PMC8741256 | DOI:10.1080/13880209.2021.2019281
Source: Pharmaceutical Biology - January 5, 2022 Category: Drugs & Pharmacology Authors: Wei Zhang Li Zhang Wen Jun Wang Shanbo Ma Mingming Wang Minna Yao Ruili Li Wei Wei Li Xian Zhao Dongmei Hu Yi Ding Jingwen Wang Source Type: research
Efficacy and safety of Chinese herbal for carotid atherosclerosis: A protocol for systematic review and network meta-analysis
CONCLUSION: The study will offer more evidence for the treatment of CAS with Chinese herbal and expand the selection range of clinicians.PROTOCOL REGISTRATION NUMBER: INPLASY2021100112.PMID:34964762 | DOI:10.1097/MD.0000000000027909
Source: Atherosclerosis - December 29, 2021 Category: Cardiology Authors: Haitao Li Hongwei Zhi Xiying Xu Yahan Wang Shuai Zhang Sishuo Zhang Source Type: research
A Systematic Review and Meta-Analysis of the Effects of Herbal Medicine Buyang Huanwu Tang in Patients with Poststroke Fatigue
Evid Based Complement Alternat Med. 2021 Dec 14;2021:4835488. doi: 10.1155/2021/4835488. eCollection 2021.ABSTRACTPoststroke fatigue (PSF) is reported to occur in 30%-72% of all patients with stroke. PSF not only is a symptom of stroke but has also been reported to adversely affect the prognosis of patients with stroke. However, no treatment has had a significant effect on PSF. In East Asian countries, several herbal medicines have been used to treat stroke, with Buyang Huanwu Tang (BHT) being the most common. This review aimed to evaluate the efficacy and safety of BHT for PSF. A literature search was conducted on MEDLINE...
Source: Evidence-based Complementary and Alternative Medicine - December 24, 2021 Category: Complementary Medicine Authors: Chul Jin Seungwon Kwon Seung-Yeon Cho Seong-Uk Park Woo-Sang Jung Sang-Kwan Moon Jung-Mi Park Chang-Nam Ko Ki-Ho Cho Source Type: research
An Improved Deep Learning Model: S-TextBLCNN for Traditional Chinese Medicine Formula Classification
Conclusion: The combination of formula feature representation and the S-TextBLCNN model improve the accuracy in formula efficacy classification. It provides a new research idea for the study of TCM formula compatibility.
Source: Frontiers in Genetics - December 22, 2021 Category: Genetics & Stem Cells Source Type: research
FDA Approves Two New Indications for XARELTO ® (rivaroxaban) to Help Prevent and Treat Blood Clots in Pediatric Patients
RARITAN, NJ, Dec. 20, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) has approved two pediatric indications for XARELTO® (rivaroxaban): the treatment of venous thromboembolism (VTE, or blood clots) and reduction in the risk of recurrent VTE in patients from birth to less than 18 years after at least five days of initial parenteral (injected or intravenous) anticoagulant treatment; and thromboprophylaxis (prevention of blood clots and blood-clot related events) in children aged two years and older with congenital heart disease who have...
Source: Johnson and Johnson - December 21, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
Yi-Zhi-Fang-Dai Formula Exerts Neuroprotective Effects Against Pyroptosis and Blood –Brain Barrier–Glymphatic Dysfunctions to Prevent Amyloid-Beta Acute Accumulation After Cerebral Ischemia and Reperfusion in Rats
Conclusion: Our study indicated that YZFDF could exert neuroprotective effects on cerebral I/R injury and prevent Aβ acute accumulation in the brain after cerebral I/R associated with inhibiting neuroinflammation-related pyroptosis and BBB–glymphatic dysfunctions.
Source: Frontiers in Pharmacology - December 15, 2021 Category: Drugs & Pharmacology Source Type: research
Xiaoxuming Decoction: A Traditional Herbal Recipe for Stroke With Emerging Therapeutic Mechanisms
Xiaoxuming decoction (XXMD) has been traditionally used to manage stroke though debates on its clinical efficacy were present in the history. Till nowadays, it is still one of the most commonly used herbal recipes for stroke. One of the reasons is that a decent proportion of ischemic stroke patients still have residue symptoms even after thrombolysis with rt-PA or endovascular thrombectomy. Numerous clinical studies have shown that XXMD is an effective alternative therapy not only at the acute stage, but also at the chronic sequelae stage of ischemic stroke. Modern techniques have isolated groups of compounds from XXMD whi...
Source: Frontiers in Pharmacology - December 14, 2021 Category: Drugs & Pharmacology Source Type: research
Using the Symptom Patient Similarity Network to Explore the Difference between the Chinese and Western Medicine Pathways of Ischemic Stroke and its Comorbidities
CONCLUSION: The research of disease classification based on community detection of symptom-shared patient networks is practical; the common molecular pathway of symptoms and herbs reflects the rationality of TCM herbs on symptoms and the wide range of therapeutic targets.PMID:34899950 | PMC:PMC8654542 | DOI:10.1155/2021/4961738
Source: Evidence-based Complementary and Alternative Medicine - December 13, 2021 Category: Complementary Medicine Authors: Lunzhong Zhang Shu Han Manli Zhao Runshun Zhang Xuebin Zhang Jing Zhang Xiaoqing Liu Yuyao He Zhao He Yunfang Dong Xiaoying Hou Zijun Mou Liyun He Hong Zhou Jie Yang Xingyan Huang Yanjie Hu Yuefeng Zhang Lili Zhang Zhengguang Chen Xiaozhen Li Yan Tan Kega Source Type: research
Efficacy and safety of Chinese herbal for carotid atherosclerosis: A protocol for systematic review and network meta-analysis
Conclusion:
The study will offer more evidence for the treatment of CAS with Chinese herbal and expand the selection range of clinicians.
Protocol registration number:
INPLASY2021100112.
Source: Medicine - November 24, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Isoquercitrin Upregulates Aldolase C Through Nrf2 to Ameliorate OGD/R-Induced Damage in SH-SY5Y Cells
Neurotox Res. 2021 Nov 13. doi: 10.1007/s12640-021-00430-1. Online ahead of print.ABSTRACTIsoquercitrin (ISO), an extract from Chinese traditional herb, exhibits potent neuroprotective roles in various disease models. However, its role in stroke is not fully understood. We established oxygen-glucose deprivation and reoxygenation (OGD/R) model in SH-SY5Y cell to study the roles of ISO in stroke. In the experiment, the changes of LDH level and cell viability (MTT) were analyzed. Apoptotic cells stained with anti-Annexin V antibody and propidium iodide (PI) were detected by flow cytometry. The mRNA and protein level of aldola...
Source: Cell Research - November 13, 2021 Category: Cytology Authors: Shi-Chang Cai Chuan-An Yi Xiang-Shang Hu Gen-Yun Tang Li-Ming Yi Xiu-Ping Li Source Type: research
