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Total 496 results found since Jan 2013.

Cassia obtusifolia seed ameliorates amyloid β-induced synaptic dysfunction through anti-inflammatory and Akt/GSK-3β pathways
Conclusion These results suggest that COE exhibits neuroprotective activities against Aβ-induced brain disorders. Graphical abstract
Source: Journal of Ethnopharmacology - December 15, 2015 Category: Drugs & Pharmacology Source Type: research

Shortcut to Better Brain Power
Natural caffeine is one of the oldest stimulants in the world. And it’s loaded with health benefits. It can enhance your mental clarity and focus, and it’s a potent antioxidant… as long as you take it in moderation and it comes from natural sources. But the problem with most energy drinks these days is the caffeine itself. It’s unnatural and synthetic. We’ve known for a long time that the antioxidant power of caffeine cuts the risk of dying from heart disease or developing Alzheimer’s. But now a study from the Department of Nutrition at the Harvard School of Public Health, researchers looked at 30 years of data...
Source: Al Sears, MD Natural Remedies - December 15, 2015 Category: Complementary Medicine Authors: Al Sears Tags: Brain Health caffeine coffee guarana Source Type: news

Anti-platelet and anti-thrombotic effect of a traditional herbal medicine Kyung-Ok-Ko
Conclusions These findings suggest that KOK elicits remarkable anti-platelet and anti-thrombotic effects with less side effect of bleeding, and therefore, it may have a therapeutic potential for the prevention of platelet-associated cardiovascular diseases. Graphical abstract
Source: Journal of Ethnopharmacology - December 17, 2015 Category: Drugs & Pharmacology Source Type: research

Neuroprotective effects of pretreatment of ginsenoside Rb1 on severe cerebral ischemia‐induced injuries in aged mice: Involvement of anti‐oxidant signaling
ConclusionsThese observations suggest that ginsenoside Rb1 could represent promising applications as anti‐oxidants for the anti‐aging treatment of neurological disorders, such as stroke, in elderly patients. Geriatr Gerontol Int 2015; ●●: ●●–●●.
Source: Geriatrics and Gerontology International - December 29, 2015 Category: Geriatrics Authors: Xiao Dong, Lei Zheng, Shujing Lu, Yanbei Yang Tags: Original Article: Biology Source Type: research

Xiaoke Pill (消渴丸) and anti-diabetic drugs: A review on clinical evidence of possible herb-drug interactions
Conclusions This review helped establish the clinically-based evidence about herb-drug interaction of Xiaoke Pill and its concomitant use with anti-diabetic drugs. The fifi ndings would help arouse the awareness of both health professionals and the general public to avoid the adverse herb-drug interactions of Xiaoke Pill in healthcare and community settings.
Source: Chinese Journal of Integrative Medicine - January 29, 2016 Category: Internal Medicine Source Type: research

Anti-inflammatory and anti-allergic effects and underlying mechanisms of Huang-Lian-Jie-Du extract: Implication for atopic dermatitis treatment
Conclusions HLJDE exerted significant anti-inflammatory and anti-allergic effects through suppressing the production of allergic and inflammatory mediators via the NF-κB and MAPKs inactivation and IκBα degradation in the LPS-stimulated RAW24.7 cells, inactivation of MAPKs and Lyn pathway in antigen-induced RBL-2H3 cells. The present study provides in vitro experimental evidence to support the use of HLJDE for the clinical treatment of AD. Graphical abstract
Source: Journal of Ethnopharmacology - March 21, 2016 Category: Drugs & Pharmacology Source Type: research

Pretty Much Nobody In The U.S. Leads A Healthy Lifestyle
Only 2.7 percent of U.S. adults hit the four key metrics of living a healthy lifestyle -- abstaining from smoking, eating well, exercising and maintaining a healthy body fat percentage -- according to a disheartening new study. The study's lifestyle benchmarks for health weren't particularly high. Being smoke-free, exercising moderately and eating USDA recommended foods don't seem like particularly difficult marks to hit. So why do so many Americans fall short of living healthy lives?  "That is the million dollar question," Ellen Smit, a senior author of the study and an associate professor at the Oregon State Un...
Source: Science - The Huffington Post - March 25, 2016 Category: Science Source Type: news

Pharmacokinetic study of isocorynoxeine metabolites mediated by cytochrome P450 enzymes in rat and human liver microsomes.
Abstract Isocorynoxeine (ICN) is one of the major bioactive tetracyclic oxindole alkaloids found in Uncaria rhynchophylla (Miq.) Jacks. that is widely used for the treatment of hypertension, vascular dementia, and stroke. The present study was undertaken to assess the plasma pharmacokinetic characteristics of major ICN metabolites, and the role of simulated gastric and intestinal fluid (SGF and SIF), human and rat liver microsomes (HLMs and RLMs), and seven recombinant human CYP enzymes in the major metabolic pathway of ICN. A rapid, sensitive and accurate UHPLC/Q-TOF MS method was validated for the simultaneous d...
Source: Fitoterapia - April 15, 2016 Category: Biochemistry Authors: Zhao L, Zang B, Qi W, Chen F, Wang H, Kano Y, Yuan D Tags: Fitoterapia Source Type: research

Discovery of a Novel Anti-Cancer Agent Targeting Both Topoisomerase I & II as well as Telomerase Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo: Cinnamomum verum Component Cuminaldehyde.
Discovery of a Novel Anti-Cancer Agent Targeting Both Topoisomerase I & II as well as Telomerase Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo: Cinnamomum verum Component Cuminaldehyde. Curr Cancer Drug Targets. 2016 Apr 26; Authors: Chen TW, Tsai KD, Yang SM, Wong HY, Liu YH, Cherng J, Chou KS, Wang YT, Cuizon J, Cherng JM Abstract Cinnamomum verum is used to make the spice cinnamon and has been used for more than 5000 years by both of the two most ancient forms of medicine in the words: Ayurveda and traditional Chinese herbal medicines for various applications such as a...
Source: Current Cancer Drug Targets - April 25, 2016 Category: Cancer & Oncology Authors: Chen TW, Tsai KD, Yang SM, Wong HY, Liu YH, Cherng J, Chou KS, Wang YT, Cuizon J, Cherng JM Tags: Curr Cancer Drug Targets Source Type: research

WITHDRAWN: Shengmai (a traditional Chinese herbal medicine) for heart failure.
CONCLUSIONS: Shengmai may be beneficial in treating heart failure, especially in terms of improving the NYHA functional classification with Shengmai plus usual treatment. However, the evidence for its effects on mortality and hospitalisation are not available yet. Therefore more studies, of higher quality and long-term follow-up, are needed to provide more evidence for the future use of Shengmai. PMID: 27128629 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - April 28, 2016 Category: Journals (General) Authors: Chen J, Yao Y, Chen H, Kwong JS, Chen J Tags: Cochrane Database Syst Rev Source Type: research

Evaluating the anticoagulant effect of medicinal plants in vitro by cheminformatics methods
Conclusion In this study, the anticoagulant effect was identified as a significant property of five medicinal plants. These plants can be regarded as likely candidates for prevention and treatment of complications in individuals with high risk of stroke or ischemia. Also, we suggest that these plants should be cautiously consumed with anticoagulant drugs (e.g. heparin) due to a risk of hemorrhage and increase in the effect of anticoagulant drugs.
Source: Journal of Herbal Medicine - May 17, 2016 Category: Complementary Medicine Source Type: research

The Role of Gastrodin on Hippocampal Neurons after N-Methyl-D-Aspartate Excitotoxicity and Experimental Temporal Lobe Seizures.
In conclusion, gastrodin failed to suppress in vivo and in vitro seizures in our study. Gastrodin showed no effect on hippocampal Schaffer collateral EPSP. These findings suggest that gastrodin does not interact with ionotropic glutamate receptors to inhibit NMDA receptor-facilitated seizures. However, gastrodin showed protective effects against NMDA toxicity on cultured hippocampal slices. Nevertheless, gastrodin is still a potential neuroprotective agent against NMDA excitotoxicity, with potential benefits for stroke and patients with epilepsy. PMID: 27188468 [PubMed - as supplied by publisher]
Source: The Chinese Journal of Physiology - May 20, 2016 Category: Physiology Tags: Chin J Physiol Source Type: research

Turmeric: Bali’s Anti-Cancer Tonic
I’m always happy to find things in my travels to bring back to you. Today I want to tell you about a miracle of nature called turmeric. Turmeric has been used to treat a wide variety of conditions. You can read about it in-depth in my latest book, Healing Herbs of Paradise. The roots of this exotic leafy plant contain curcumin, a very powerful antioxidant that also has remarkable anti-inflammatory properties.1,2,3 What Does Curcumin Do? Curcumin neutralizes free radicals… those nasty little chemicals that travel through your body and cause damage to healthy cells and cell membranes. Which means curcumin effectivel...
Source: Al Sears, MD Natural Remedies - May 25, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Cancer Source Type: news

Rooibos: Better Than Green Tea For Many Reasons
When I hiked Table Mountain on my last trip to South Africa, the locals told me about an herb that is better than green tea that kept them disease-free. African Bushmen have used this herb since before recorded history, but it’s still pretty rare here in America. Studies on this plant are being done all over the world. But not in the U.S. Because Big Pharma and the FDA aren’t interested in a natural cure that can’t be patented — or profited from. What is This South African Herb? I’m talking about an herb called Rooibos — or red bush in Afrikaans. Rooibos (pronounced roy-boss) provides a whole lo...
Source: Al Sears, MD Natural Remedies - May 27, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Natural Cures Source Type: news

PPI Side Effects Destroying Your Blood Vessels
It seems whenever I turn on my TV these days, there’s Larry the Cable Guy with a quick fix for heartburn. He makes it sound so simple. Just pop a pill, eat all the chili dogs you want, and no more heartburn… at least for a couple of weeks. What Is Heartburn? Heartburn is an irritation of the esophagus that is caused by stomach acid. It has nothing to do with the heart. But a new study has found a link between proton-pump inhibitors (PPIs) — heartburn drugs — and the premature aging of blood vessels. Heartburn Drugs PPI Side Effects Researchers focused on the effects of two PPIs, one of which is Nexium. They...
Source: Al Sears, MD Natural Remedies - June 16, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Heart Health Source Type: news