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Immuno-histological detection of resistant columnar units and vulnerable networks in the rat retina after asphyxia-induced transient cardiac arrest
CONCLUSIONS: Regardless of the many defects, the surviving neuronal structures seemed to be able to maintain retinal functionality, which can be additionally improved by regenerative processes true to the "use it or lose it" dogma.PMID:34334436 | DOI:10.3233/RNN-211174
Source: Restorative Neurology and Neuroscience - August 2, 2021 Category: Neurology Authors: Gerburg Keilhoff Maximilian Titze Uwe Ebmeyer Source Type: research

Assessment of the outer retina and choroid in white matter lesions participants using swept ‐source optical coherence tomography
ConclusionsAssessing retinal thickness and choroidal changes with the SS-OCTA as a proxy for WML could prove to be a potentially valuable tool for early detection of cognitive decline and other neurodegenerative diseases.
Source: Brain and Behavior - July 22, 2021 Category: Neurology Authors: William Robert Kwapong, Yuzhu Gao, Yuying Yan, Yifan Zhang, Ming Zhang, Bo Wu Tags: ORIGINAL RESEARCH Source Type: research

Borderzone Infarction and Small Vessel Disease in a Sample of Egyptian Stroke Patients: Differences and Similarities
Conclusion: Limb shaking, retinal claudication or syncope, with MRI showing rosary pattern of white matter hyperintensity, few microbleeds and markedly impaired perfusion favor the diagnosis of borderzone infarctions. On the other hand, presence of lacunae, FLAIR showing symmetrical WMH and microbleeds with minimal or no perfusion deficit suggests the diagnosis of small vessel disease.
Source: Neurology India - June 24, 2021 Category: Neurology Authors: Nevine M El Nahas Hany M Aref Taha K Alloush Nagia A Fahmy Khaled A Ahmed Ahmed A El Basiouny Mohamed A Tork Ahmed M Elbokl Hossam M Shokri Source Type: research

Neurological impact of eosinophilic granulomatosis with polyangiitis
AbstractNervous system (NS)  affection may occur in Eosinophilic Granulomatosis with Polyangiitis (EGPA), but its clinical manifestations and pathophysiology are rarely described. Our aims are to characterize central and peripheral NS (CNS/PNS) involvement and compare biological markers in EGPA patients with and w ithout neurological manifestations. Retrospective observational study, including EGPA patients with and without neurological manifestations. Demographics, clinical data, and immunological markers were analyzed. Descriptive and inferential statistics were performed. Sixteen patients were included ...
Source: Acta Neurologica Belgica - April 27, 2021 Category: Neurology Source Type: research

Retinal Microvascular Changes in Subtypes of Ischemic Stroke
Conclusion: Retinal MVD0.5−1.0DD (>82.23 μm) might be associated with the AT stroke subtype; however, we need large-scale prospective studies in future to explore the underlying mechanism and causal explanation for this finding.
Source: Frontiers in Neurology - January 27, 2021 Category: Neurology Source Type: research

Variations in the Presence of Carotid Intraplaque Hemorrhage Across Age Categories: What Age Groups Are Most Likely to Benefit From Plaque Imaging?
Although carotid artery intraplaque hemorrhage (IPH) is a known risk-factor for cerebral ischemic events in patients of advanced age, its prevalence in younger cohorts is less certain. The purpose of this study was to assess the prevalence of carotid artery IPH across the age spectrum. A retrospective review was completed of all adult patients from our institution who underwent neck MRA with high-resolution carotid plaque imaging between 2017 and 2020. The mean ages of patients with and without IPH were calculated. The prevalence of IPH was compared between patients that were categorized into age groups. Patients with and ...
Source: Frontiers in Neurology - December 14, 2020 Category: Neurology Source Type: research

Management of Acute Central Retinal Artery Occlusion, a “Retinal Stroke”: An Institutional Series and Literature Review
Acute central retinal artery occlusion (CRAO) is an ophthalmologic emergency that often results in permanent vision loss. Over 25% are associated with acute cerebral ischemia. In the absence of existing Level I treatment options, this study aims to examine institutional practice patterns and review the literature to develop a formalized approach to the treatment of CRAO in the era of ischemic stroke protocols.
Source: Journal of Stroke and Cerebrovascular Diseases - December 11, 2020 Category: Neurology Authors: Katriel E. Lee, Christine Tschoe, Stephanie A. Coffman, Carol Kittel, Patrick A. Brown, Quang Vu, Kyle M. Fargen, Bartlett H. Hayes, Stacey Q. Wolfe Source Type: research

Remote Ischemic Post-Conditioning Therapy is Protective in Mouse Model of Traumatic Optic Neuropathy
AbstractTraumatic optic neuropathy (TON) is characterized by visual dysfunction after indirect or direct injury to the optic nerve following blunt head trauma. TON is associated with increased oxidative stress and inflammation resulting in retinal ganglion cell (RGC) death. Remote ischemic post-conditioning (RIC) has been shown to enhance endogenous protective mechanisms in diverse disease models including stroke, vascular cognitive impairment (VCI), retinal injury and optic nerve injury. However, the protective mechanisms underlying the improvement of retinal function and RGC survival after RIC treatment remain unclear. H...
Source: NeuroMolecular Medicine - November 13, 2020 Category: Neurology Source Type: research

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