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Total 349 results found since Jan 2013.
Adverse outcomes after total and unicompartmental knee replacement in 101 330 matched patients: a study of data from the National Joint Registry for England and Wales
Publication date: 18–24 October 2014 Source:The Lancet, Volume 384, Issue 9952 Author(s): Alexander D Liddle , Andrew Judge , Hemant Pandit , David W Murray Background Total knee replacement (TKR) or unicompartmental knee replacement (UKR) are options for end-stage osteoarthritis. However, comparisons between the two procedures are confounded by differences in baseline characteristics of patients undergoing either procedure and by insufficient reporting of endpoints other than revision. We aimed to compare adverse outcomes for each procedure in matched patients. Methods With propensity score techniques, we compared ma...
Source: The Lancet - October 17, 2014 Category: Journals (General) Source Type: research
Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial
This study is registered with ClinicalTrials.gov, number NCT00349622. Findings Stage 3 included 66 participants from stages 1 and 2 and 448 new participants. In total, 340 participants were randomly allocated to ceftriaxone and 173 to placebo. During stages 1 and 2, mean ALSFRS-R declined more slowly in participants who received 4 g ceftriaxone than in those on placebo (difference 0·51 units per month, 95% CI 0·02 to 1·00; p=0·0416), but in stage 3 functional decline between the treatment groups did not differ (0·09, −0·06 to 0·24; p=0·2370). No significant differences in survival between the groups were recorde...
Source: The Lancet Neurology - October 17, 2014 Category: Neurology Source Type: research
We Must Beat Alzheimer's Before It Beats Us! And Here's How!
Alzheimer's Has Become the Scariest Disease of Later Life
It's true. In a new Age Wave/Merrill Lynch study titled Health and Retirement: Planning for the Great Unknown, we surveyed a representative sample of over 3,000 Americans to uncover both their hopes and their concerns about health and healthcare expenses.
Overwhelmingly, the study respondents said that the most important ingredient for a happy retirement is health. And while all diseases can disrupt both health and wealth in retirement, people of all ages now say the scariest disabling condition in later life is Alzheimer's disease. In fact, Alzheimer's was cited...
Source: Healthy Living - The Huffington Post - November 20, 2014 Category: Consumer Health News Source Type: news
Half a million California seniors fall repeatedly but many don’t seek medical attention
More than half a million older Californians — 12.6 percent of the state’s senior population — fall more than once a year, but nearly 60 percent of them fail to seek medical attention afterward, according to a new study by the UCLA Center for Health Policy Research.
The study also found that among those who did seek treatment, 40 percent did not receive counseling from a medical provider about how to prevent future falls.
Falls are the leading injury-related cause of death and need for medical care among Californians age 65 and older, according to the study. In 2012, more than 1,800 seniors died after falling and se...
Source: UCLA Newsroom: Health Sciences - November 21, 2014 Category: Universities & Medical Training Source Type: news
Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million people
This study is registered at ClinicalTrials.gov (NCT01804439). Findings Our cohort consisted of 1 921 260 individuals, of whom 1 887 062 (98·2%) did not have diabetes and 34 198 (1·8%) had type 2 diabetes. We observed 113 638 first presentations of cardiovascular disease during a median follow-up of 5·5 years (IQR 2·1–10·1). Of people with type 2 diabetes, 6137 (17·9%) had a first cardiovascular presentation, the most common of which were peripheral arterial disease (reported in 992 [16·2%] of 6137 patients) and heart failure (866 [14·1%] of 6137 patients). Type 2 diabetes was positively associated wi...
Source: The Lancet Diabetes and Endocrinology - December 5, 2014 Category: Endocrinology Source Type: research
Prediction of manifest Huntington's disease with clinical and imaging measures: a prospective observational study
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Jane S Paulsen , Jeffrey D Long , Christopher A Ross , Deborah L Harrington , Cheryl J Erwin , Janet K Williams , Holly James Westervelt , Hans J Johnson , Elizabeth H Aylward , Ying Zhang , H Jeremy Bockholt , Roger A Barker Background Although the association between cytosine-adenine-guanine (CAG) repeat length and age at onset of Huntington's disease is well known, improved prediction of onset would be advantageous for clinical trial design and prognostic counselling. We compared various measures for tracking progression and pr...
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research
Prevention Science Should Be a Higher Federal Funding Priority
This study highlights inadequate investment of federal funding for science that will help us better prevent chronic disease. Investing in prevention -- and prevention science -- should become a much higher priority for federal research. It's essential if the United States is to improve the health of our population and save future generations of Americans from the burden of preventable disease.
Source: Healthy Living - The Huffington Post - January 7, 2015 Category: Consumer Health News Source Type: news
Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program
The Brain and Body Donation Program (BBDP) at Banner Sun Health Research Institute (http://www.brainandbodydonationprogram.org) started in 1987 with brain‐only donations and currently has banked more than 1600 brains. More than 430 whole‐body donations have been received since this service was commenced in 2005. The collective academic output of the BBDP is now described as the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND). Most BBDP subjects are enrolled as cognitively normal volunteers residing in the retirement communities of metropolitan Phoenix, Arizona. Specific recruitment efforts are also dire...
Source: Neuropathology - January 26, 2015 Category: Neurology Authors: Thomas G. Beach, Charles H. Adler, Lucia I. Sue, Geidy Serrano, Holly A. Shill, Douglas G. Walker, LihFen Lue, Alex E. Roher, Brittany N. Dugger, Chera Maarouf, Alex C. Birdsill, Anthony Intorcia, Megan Saxon‐Labelle, Joel Pullen, Alexander Scroggins, J Tags: SYMPOSIUM: BRAIN BANK Source Type: research
UCLA researchers identify molecular ‘switch’ that causes Huntington’s disease–like symptoms in mice
This study makes clear that a major neuroprotective function of N17 is to prevent the mutant protein from entering the nucleus and eliciting more severe toxicities,” Yang said, adding that the result is consistent with findings from several studies of other, related disorders in which mutant proteins with expanded glutamine in the nucleus are key for jump-starting a disease.
The researchers also found that the mice in the study experienced inflammation in the brain somewhat similar to that found in people with Huntington’s.
“Neuroinflammation is emerging as a potentially shared mechanism in multiple neurodegenerative...
Source: UCLA Newsroom: Health Sciences - February 13, 2015 Category: Universities & Medical Training Source Type: news
Facing up to SUDEP
Epilepsy is a chronic condition that affects approximately 2.3 million people in the United States.1 Approximately one-third of people with epilepsy continue to have seizures despite adequate medication trials and adherence to medical recommendations.2 People of all races and backgrounds, young and old, are affected by epilepsy from a variety of etiologies, and epilepsy carries a high burden of comorbidity including the risk of death. The overwhelming majority of the deaths are due to sudden unexpected death in epilepsy (SUDEP), which is closely related to a recent convulsive or tonic-clonic seizure,3 and thus may be a dir...
Source: Neurology - February 16, 2015 Category: Neurology Authors: Dworetzky, B., Schuele, S. U. Tags: All Sleep Disorders, EEG, Epilepsy monitoring, Generalized seizures EDITORIALS Source Type: research
Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial
This study is registered with ClinicalTrials.gov, number NCT00968708. Findings 5380 patients were assigned to alogliptin (n=2701) or placebo (n=2679) and followed up for a median of 533 days (IQR 280–751). The exploratory extended MACE endpoint was seen in 433 (16·0%) patients assigned to alogliptin and in 441 (16·5%) assigned to placebo (hazard ratio [HR] 0·98, 95% CI 0·86–1·12). Hospital admission for heart failure was the first event in 85 (3·1%) patients taking alogliptin compared with 79 (2·9%) taking placebo (HR 1·07, 95% CI 0·79–1·46). Alogliptin had no effect on composite events of cardiovascular d...
Source: The Lancet - March 12, 2015 Category: Journals (General) Source Type: research
For most children with HIV and low immune cell count, cells rebound after treatment
UCLA Health Sciences
Dr. Paul Krogstad
Most children with HIV who have low levels of a key immune cell eventually recover levels of this cell after they begin treatment, according to a new study conducted by researchers at UCLA and other institutions in the U.S. and Brazil.
The researchers were funded by the National Institutes of Health.
“We were pleased to find that the vast majority of children experience immune system recovery with effective therapy,” said Dr. Paul Krogstad, professor of pediatric infectious diseases and of molecular and medical pharmacology at the David Geffen School of Medicine at UCLA, and t...
Source: UCLA Newsroom: Health Sciences - March 26, 2015 Category: Universities & Medical Training Source Type: news
Precision medicine is coming, but not anytime soon
President Obama’s announcement of a Precision Medicine Initiative was one of the few items in this year’s State of the Union address to garner bipartisan support. And for good reason. Precision medicine, also known as personalized medicine, offers the promise of health care — from prevention to diagnosis to treatment — based on your unique DNA profile. Who wouldn’t want that?
We’ve already had a taste of precision medicine. Relatively low-tech therapies like eyeglasses, orthotic devices, allergy treatments, and blood transfusions have long been personalized for the individual. Genetic analysis o...
Source: New Harvard Health Information - March 26, 2015 Category: Consumer Health News Authors: Beverly Merz Tags: Health care personalized health care precision medicine Source Type: news
A novel risk score to predict cardiovascular disease risk in national populations (Globorisk): a pooled analysis of prospective cohorts and health examination surveys
Publication date: Available online 26 March 2015 Source:The Lancet Diabetes & Endocrinology Author(s): Kaveh Hajifathalian , Peter Ueda , Yuan Lu , Mark Woodward , Alireza Ahmadvand , Carlos A Aguilar-Salinas , Fereidoun Azizi , Renata Cifkova , Mariachiara Di Cesare , Louise Eriksen , Farshad Farzadfar , Nayu Ikeda , Davood Khalili , Young-Ho Khang , Vera Lanska , Luz León-Muñoz , Dianna Magliano , Kelias P Msyamboza , Kyungwon Oh , Fernando Rodríguez-Artalejo , Rosalba Rojas-Martinez , Jonathan E Shaw , Gretchen A Stevens , Janne Tolstrup , Bin Zhou , Joshua A Salomon , Majid Ezzati , Goodarz Danaei Backgrou...
Source: The Lancet Diabetes and Endocrinology - March 27, 2015 Category: Endocrinology Source Type: research
UK funding for stroke and dementia research still too low, study says
Sums spent on conditions bear little relation to their costs to health services, as compared with cancer or heart disease, say researchers Continue reading...
Source: Guardian Unlimited Science - April 13, 2015 Category: Science Authors: James Meikle Tags: Dementia Research funding Medical research UK news Society Science Politics Source Type: news
