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Specialty: Neurology
Education: Study
Management: National Institutes of Health (NIH)
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Total 273 results found since Jan 2013.
Intracerebral Hemorrhage and Outcome After Thrombolysis in Stroke Patients Using Selective Serotonin-Reuptake Inhibitors Clinical Sciences
Background and Purpose—Selective serotonin-reuptake inhibitors (SSRIs) impair platelet function and have been linked to a higher risk of spontaneous intracerebral hemorrhage—an association that may be augmented by oral anticoagulants (OAC). We aimed to assess whether preadmission treatment with SSRIs in patients with acute ischemic stroke is associated with post-thrombolysis symptomatic intracerebral hemorrhage (sICH) and functional outcome.Methods—A multicenter retrospective analysis was conducted in prospective registries of patients treated by thrombolysis within 4.5 hours of stroke onset. The association between ...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Jan F. Scheitz, Guillaume Turc, Linda Kuȷala, Alexandros A. Polymeris, Mirȷam R. Heldner, Thomas P. Zonneveld, Hebun Erdur, Sami Curtze, Christopher Traenka, Celine Breniere, Roland Wiest, Andrea Rocco, Gerli Sibolt, Henrik Gensicke, Matthia Tags: Complications, Ischemic Stroke Original Contributions Source Type: research
Predictors of Good Outcome After Endovascular Therapy for Vertebrobasilar Occlusion Stroke Clinical Sciences
Background and Purpose—Endovascular therapy is increasingly used in acute ischemic stroke treatment and is now considered the gold standard approach for selected patient populations. Prior studies have demonstrated that eventual patient outcomes depend on both patient-specific factors and procedural considerations. However, these factors remain unclear for acute basilar artery occlusion stroke. We sought to determine prognostic factors of good outcome in acute posterior circulation large vessel occlusion strokes treated with endovascular therapy.Methods—We reviewed our prospectively collected endovascular databases at ...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Mehdi Bouslama, Diogo C. Haussen, Amin Aghaebrahim, Jonathan A. Grossberg, Gregory Walker, Srikant Rangaraju, Anat Horev, Michael R. Frankel, Raul G. Nogueira, Tudor G. Jovin, Ashutosh P. Jadhav Tags: Quality and Outcomes, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research
Mechanical Thrombectomy for Minor and Mild Stroke Patients Harboring Large Vessel Occlusion in the Anterior Circulation Clinical Sciences
Background and Purpose—Proximal large vessel occlusion (LVO) is present in up to 30% of minor strokes. The effectiveness of mechanical thrombectomy (MT) in the subgroup of minor stroke with LVO in the anterior circulation is still open to debate. Data about MT in this subgroup of patients are sparse, and their optimal management has not yet been defined. The purpose of this multicenter cohort study was to evaluate the effectiveness of MT in patients experiencing acute ischemic stroke (AIS) because of LVO in the anterior circulation, presenting with minor-to-mild stroke symptoms (National Institutes of Health Stroke Scale score of
Source: Stroke - November 27, 2017 Category: Neurology Authors: Cyril Dargazanli, Caroline Arquizan, Benȷamin Gory, Arturo Consoli, Julien Labreuche, Hocine Redȷem, Omer Eker, Jean–Pierre Decroix, Astrid Corlobe, Isabelle Mourand, Nicolas Gaillard, Xavier Ayrignac, Mahmoud Charif, Alain Duhamel, Pa Tags: Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research
Serum neuron specific enolase may be a marker to predict the severity and outcome of cerebral venous thrombosis
The objective is to explore the effective of baseline serum neuron specific enolase (NSE) on predicting the severity and outcome in patients with cerebral venous thrombosis (CVT). A total of 156 patients confirmed as CVT in Xuanwu Hospital were enrolled in this retrospective study from March 2011 through September 2016. The severity was evaluated with the National Institutes of Health Stroke Score (NIHSS), intracranial pressure (ICP), and CVT-related complications; the outcome was evaluated by modified Rankin Scale (mRS); the relationship between baseline serum NSE and mRS was analyzed with receiver operating characteristi...
Source: Journal of Neurology - November 11, 2017 Category: Neurology Source Type: research
Clinical Importance of Temporal Bone Features for the Efficacy of Contrast-Enhanced Sonothrombolysis: a Retrospective Analysis of the NOR-SASS Trial
AbstractContrast-enhanced sonothrombolysis (CEST) seems to be a safe and promising treatment in acute ischemic stroke. It remains unknown if temporal bone features may influence the efficacy of CEST. We investigated the association between different temporal bone features on admission computed tomography (CT) scan and the outcome in acute ischemic stroke patients included in the randomized Norwegian Sonothrombolysis in Acute Stroke Study (NOR-SASS). Patients diagnosed as stroke mimics and those with infratentorial stroke or with incorrect insonation were excluded. We retrospectively assessed temporal bone heterogeneity (pr...
Source: Translational Stroke Research - November 8, 2017 Category: Neurology Source Type: research
Worse Outcome in Stroke Patients Treated with rt-PA Without Early Reperfusion: Associated Factors
AbstractBased on preclinical studies suggesting that recombinant tissue plasminogen activator (rt-PA) may promote ischemic brain injuries, we investigated in patients the possible risk of worse clinical outcome after rt-PA treatment as a result of its inability to resolve cerebral ischemia. Here, we designed a cohort study using a retrospective analysis of patients who received treatment with intravenous (4.5-h window) or intraarterial rt-PA, without or with thrombectomy. Controls were consecutive patients who did not receive recanalization treatment, who met all inclusion criteria. As a marker of reperfusion, we defined t...
Source: Translational Stroke Research - November 7, 2017 Category: Neurology Source Type: research
External Validation of the ISAN, A2DS2, and AIS-APS Scores for Predicting Stroke-Associated Pneumonia
The Prestroke Independence, Sex, Age, National Institutes of Health Stroke Scale (ISAN), Age, Atrial Fibrillation, Dysphagia, male sex, and National Institutes of Health Stroke Scale (A2DS2), and acute ischemic stroke-associated pneumonia score (AIS-APS) scores were created to predict stroke-associated pneumonia (SAP), one of the most important medical stroke complications. External validation of all such scores in an acute stroke population was the aim of our study.
Source: Journal of Stroke and Cerebrovascular Diseases - November 2, 2017 Category: Neurology Authors: Elena Zapata-Arriaza, Francisco Moniche, Pardo-Galiana Blanca, Alejandro Bustamante, Irene Escudero-Mart ínez, Oscar Uclés, Ángela Ollero-Ortiz, Jose Antonio Sánchez-García, Miguel Ángel Gamero, Ángeles Quesada, Diana Vidal De Francisco, Mercedes R Source Type: research
Ischemic core thresholds change with time to reperfusion: A case control study
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Source: Annals of Neurology - November 1, 2017 Category: Neurology Authors: Andrew Bivard, Tim Kleinig, Ferdinand Miteff, Kenneth Butcher, Longting Lin, Christopher Levi, Mark Parsons Tags: Research Article Source Type: research
Early Screening Parameters for Dysphagia in Acute Ischemic Stroke
This study aimed to detect early and easily assessable predictors of dysphagia in a large cohort of patients with acute ischemic stroke.Methods: Our analysis was based on data from a prospective in-hospital registry. Patients with ischemic stroke were included over the course of 3 years. Patients were scheduled to undergo a clinical swallowing investigation within the first 24 h after hospital admission. Step-wise multivariate logistic regression was used to identify independent predictors of dysphagia in general and of pneumonia in particular.Results: 1,646 patients with ischemic stroke were included. Stroke severity in t...
Source: Cerebrovascular Diseases - October 25, 2017 Category: Neurology Source Type: research
Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis
Publication date: November 2017 Source:The Lancet Neurology, Volume 16, Issue 11 Author(s): Barbara Schormair, Chen Zhao, Steven Bell, Erik Tilch, Aaro V Salminen, Benno Pütz, Yves Dauvilliers, Ambra Stefani, Birgit Högl, Werner Poewe, David Kemlink, Karel Sonka, Cornelius G Bachmann, Walter Paulus, Claudia Trenkwalder, Wolfgang H Oertel, Magdolna Hornyak, Maris Teder-Laving, Andres Metspalu, Georgios M Hadjigeorgiou, Olli Polo, Ingo Fietze, Owen A Ross, Zbigniew Wszolek, Adam S Butterworth, Nicole Soranzo, Willem H Ouwehand, David J Roberts, John Danesh, Richard P Allen, Christopher J Earley, William G Ondo, Lan Xiong,...
Source: The Lancet Neurology - October 11, 2017 Category: Neurology Source Type: research
Prophylactic Anticonvulsants in Intracerebral Hemorrhage
DiscussionLevetiracetam was routinely prescribed following ICH and was not associated with worse outcomes. Future investigations should examine the effect of prophylactic levetiracetam on cost and neuropsychological outcomes as well as the role of continuous EEG in identifying subclinical seizures.
Source: Neurocritical Care - October 1, 2017 Category: Neurology Source Type: research
Influence of Penumbral Reperfusion on Clinical Outcome Depends on Baseline Ischemic Core Volume Clinical Sciences
This study included 1507 patients. Reperfused penumbral volume had moderate ability to predict 90-day mRS 0 to 1 (area under the curve, 0.77; R2, 0.28; P
Source: Stroke - September 25, 2017 Category: Neurology Authors: Chushuang Chen, Mark W. Parsons, Matthew Clapham, Christopher Oldmeadow, Christopher R. Levi, Longting Lin, Xin Cheng, Min Lou, Timothy J. Kleinig, Kenneth S. Butcher, Qiang Dong, Andrew Bivard Tags: Ischemic Stroke Original Contributions Source Type: research
Tissue-Selective Salvage of the White Matter by Successful Endovascular Stroke Therapy Clinical Sciences
This study examines occurrence, determinants, and clinical significance of such effects.Methods—Three hundred twenty-two patients with acute middle cerebral artery occlusion subjected to mechanical thrombectomy were included. Infarct patterns were categorized into WM− (sparing the WM) and WM+ (involving WM). National Institutes of Health Stroke Scale–based measures of neurological outcome, including National Institutes of Health Stroke Scale improvement or National Institutes of Health Stroke Scale worsening, good functional midterm outcome (day 90-modified Rankin Scale score of ≤2), the occurrence of malignant swe...
Source: Stroke - September 25, 2017 Category: Neurology Authors: Justus F. Kleine, Mirjam Kaesmacher, Benedikt Wiestler, Johannes Kaesmacher Tags: Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research
Early Screening Parameters for Dysphagia in Acute Ischemic Stroke
This study aimed to detect early and easily assessable predictors of dysphagia in a large cohort of patients with acute ischemic stroke.Methods: Our analysis was based on data from a prospective in-hospital registry. Patients with ischemic stroke were included over the course of 3 years. Patients were scheduled to undergo a clinical swallowing investigation within the first 24 h after hospital admission. Step-wise multivariate logistic regression was used to identify independent predictors of dysphagia in general and of pneumonia in particular.Results: 1,646 patients with ischemic stroke were included. Stroke severity in t...
Source: Cerebrovascular Diseases - September 13, 2017 Category: Neurology Source Type: research
Plasma Glial Fibrillary Acidic Protein in the Differential Diagnosis of Intracerebral Hemorrhage Brief Report
Background and Purpose—Plasma GFAP (glial fibrillary acidic protein) has recently emerged as a potential biomarker for the differentiation of acute intracerebral hemorrhage (ICH) from acute ischemic stroke (AIS). We prospectively assessed the diagnostic accuracy of GFAP in the differential diagnosis of ICH.Methods—Consecutive patients presenting to the emergency department within 6 hours from symptom onset were evaluated. All patients underwent extensive diagnostic work-up and were classified according to discharge diagnosis in AIS, ICH, subarachnoid hemorrhage, and stroke mimics. GFAP was also measured in healthy volu...
Source: Stroke - August 28, 2017 Category: Neurology Authors: Aristeidis H. Katsanos, Konstantinos Makris, Dimitra Stefani, Katerina Koniari, Eleni Gialouri, Moses Lelekis, Maria Chondrogianni, Christina Zompola, Efthymios Dardiotis, Ioannis Rizos, John Parissis, Eleni Boutati, Konstantinos Voumvourakis, Georgios Ts Tags: Intracranial Hemorrhage, Ischemic Stroke Brief Reports Source Type: research
