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Effects of Unilateral Upper Limb Training in Two Distinct Prognostic Groups Early After Stroke: The EXPLICIT-Stroke Randomized Clinical Trial
Conclusions. Three weeks of early mCIMT is superior to usual care in terms of regaining upper limb capacity in patients with a favorable prognosis; 3 weeks of EMG-NMS in patients with an unfavorable prognosis is not beneficial. Despite meaningful improvements in upper limb capacity, no evidence was found that the time-dependent neurological improvements early poststroke are significantly influenced by either mCIMT or EMG-NMS.
Source: Neurorehabilitation and Neural Repair - September 11, 2016 Category: Neurology Authors: Kwakkel, G., Winters, C., van Wegen, E. E. H., Nijland, R. H. M., van Kuijk, A. A. A., Visser-Meily, A., de Groot, J., de Vlugt, E., Arendzen, J. H., Geurts, A. C. H., Meskers, C. G. M., on behalf of the EXPLICIT-Stroke Consortium Tags: Clinical Research Articles Source Type: research

Walking Quality During Inpatient Stroke Rehabilitation Assessed by Wireless Sensing (P5.176)
CONCLUSIONS: The laboratory-quality gait metrics calculated by our wireless sensor system were sensitive to functional improvements during a period of known clinical recovery. Commercial sensor systems, for which steps counts are inaccurate at the slow speeds typical of hemi-paretic walking, have difficulty producing outcomes related to motor control in persons disabled by neurologic disease. Measurement of the quantity and quality of movements performed during daily activities enables clinicians and researchers to supervise gait training and skills practice during rehabilitation.Disclosure: Dr. Dorsch has nothing to discl...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Dorsch, A., Thomas, S., Dobkin, B. Tags: Neuro-rehabilitation: Stroke Source Type: research

Anticipatory Postural Adjustments During Gait Initiation in Stroke Patients
Conclusion This systematic review provides an update on GI-APA reorganization following stroke. Stroke patients present atypical GI-APA patterns, longer GI-APA duration and lower GI-APA amplitude compared to healthy people, regardless of which leg is used as the leading or trailing leg. GI is facilitated when the non-paretic leg is used as the trailing leg because the weakness of the paretic leg leads to difficulties in supporting body weight during the upcoming stance phase. Further experiments should include distinct groups of patients in order to describe GI-APA features in acute, subacute and chronic stroke, and the i...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research

Acupuncture for Post-stroke Shoulder-Hand Syndrome: A Systematic Review and Meta-Analysis
Conclusions: Acupuncture therapy seems effective for motor function, pain relief and activities of daily living in stroke patients with mild SHS, when it is used in combination with rehabilitation. The low certainty of evidence downgrades our confidence in making recommendations to clinical practice. Introduction Shoulder-hand syndrome (SHS) is a common condition among people who have had a stroke, with its reported prevalence ranging from 12% to 49% (1, 2). The main symptoms of SHS include pain, hyperalgesia, joint swelling and limitations in range of motion (ROM) (3). Post-stroke SHS is also named type I complex ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Using Dental Pulp Stem Cells for Stroke Therapy
Conclusion and Future Perspectives Stem cell-based therapy is a promising alternative for stroke treatment. While stem cells from different sources, including induced PSC, ESC, MSC, and NSC, have been investigated, using NSC and enhancing the natural mechanisms is most appropriate for brain repair. In preclinical models of stroke, stem cell transplantation has led to positive outcomes through a variety of cellular and molecular mechanisms, many being mediated by the array of beneficial factors produced by the cells. Recent advances in cellular reprogramming have provided alternative sources of NSC to be investigated, allo...
Source: Frontiers in Neurology - April 28, 2019 Category: Neurology Source Type: research

1H NMR-Based Metabolomics Reveals Refined-Huang-Lian-Jie-Du-Decoction (BBG) as a Potential Ischemic Stroke Treatment Drug With Efficacy and a Favorable Therapeutic Window
This study was carried out in accordance with the recommendations of Animal Ethics Committee of China Pharmaceutical University. The protocol was approved by Animal Ethics Committee of China Pharmaceutical University. Author Contributions JW, MY, and LK conceived the experiments and helped to coordinate support and funding. XF performed the research and drafted the manuscript. SL, YL, and DX participated in the experiments. JW analyzed the data and edited the paper. All authors read and approved the final manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of an...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Paradoxical Motor Recovery From a First Stroke After Induction of a Second Stroke: Reopening a Postischemic Sensitive Period
Conclusions. New ischemia can reopen a sensitive period of heightened responsiveness to training and mediate full recovery from a previous stroke.
Source: Neurorehabilitation and Neural Repair - August 8, 2016 Category: Neurology Authors: Zeiler, S. R., Hubbard, R., Gibson, E. M., Zheng, T., Ng, K., OBrien, R., Krakauer, J. W. Tags: Basic Science Article Source Type: research

How Can You Mend a Broken Brain? - Neurorestorative Approaches to Stroke Recovery
Background: Stroke is a devastating disorder that strikes approximately 15 million people worldwide. While most patients survive stroke, many are left with lifelong impairments, thereby making stroke the leading cause of permanent neurological disability. Despite this, there are a few options for treatment of acute stroke. Restoration of blood flow using clot-dissolving drugs has produced impressive benefits in some patients. However, for these drugs to be effective, they must be given soon after stroke onset and relatively only a few stroke patients reach hospital within this time. Side effects of these compounds further ...
Source: Cerebrovascular Diseases - November 12, 2014 Category: Neurology Source Type: research

How Can You Mend a Broken Brain - Neurorestorative Approaches to Stroke Recovery
Background: Stroke is a devastating disorder that strikes approximately 15 million people worldwide. While most patients survive stroke, many are left with lifelong impairments, thereby making stroke the leading cause of permanent neurological disability. Despite this, there are a few options for treatment of acute stroke. Restoration of blood flow using clot-dissolving drugs has produced impressive benefits in some patients. However, for these drugs to be effective, they must be given soon after stroke onset and relatively only a few stroke patients reach hospital within this time. Side effects of these compounds further ...
Source: Cerebrovascular Diseases - November 13, 2014 Category: Neurology Source Type: research

EXERTION: a pilot trial on the effect of aerobic, smartwatch-controlled exercise on stroke recovery: effects on motor function, structural repair, cognition, mental well-being, and the immune system
This study investigates the effect of smartwatch-controlled aerobic exercise on functional recovery, cognition, emotional well-being, the immune system, and neuronal network reorganization in stroke patients. Trial registration ClinicalTrials.gov NCT Number: NCT05690165. First posted19 January 2023. Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT05690165.PMID:37170385 | DOI:10.1186/s42466-023-00244-w
Source: Cell Research - May 11, 2023 Category: Cytology Authors: Frederike A Straeten Stephanie van Zyl Bastian Maus Jochen Bauer Heiner Raum Catharina C Gross Sabine Bruchmann Nils C Landmeyer Cornelius Faber Jens Minnerup Antje Schmidt-Pogoda Source Type: research

Reducing Abnormal Muscle Coactivation After Stroke Using a Myoelectric-Computer Interface: A Pilot Study
Conclusions. These results suggest that the MCI was an effective tool in directly retraining muscle activation patterns following stroke.
Source: Neurorehabilitation and Neural Repair - May 22, 2014 Category: Neurology Authors: Wright, Z. A., Rymer, W. Z., Slutzky, M. W. Tags: Clinical Research Articles Source Type: research

The Effect of Arm Support Combined With Rehabilitation Games on Upper-Extremity Function in Subacute Stroke: A Randomized Controlled Trial
Conclusions. AS training with computerized exercises is as effective as conventional therapy dedicated to the arm to improve arm function and activity in subacute stroke rehabilitation, when applied at the same dose.
Source: Neurorehabilitation and Neural Repair - December 24, 2014 Category: Neurology Authors: Prange, G. B., Kottink, A. I. R., Buurke, J. H., Eckhardt, M. M. E. M., van Keulen-Rouweler, B. J., Ribbers, G. M., Rietman, J. S. Tags: Clinical Research Articles Source Type: research

Spatial and Temporal Asymmetries in Gait Predict Split-Belt Adaptation Behavior in Stroke
Conclusion. This work demonstrates that stroke patients adapt toward their baseline temporal and spatial asymmetries of walking independently of one another. We define how a given split-belt training session would affect asymmetries in these domains, which must be considered when developing rehabilitation interventions for stroke patients.
Source: Neurorehabilitation and Neural Repair - February 11, 2014 Category: Neurology Authors: Malone, L. A., Bastian, A. J. Tags: Clinical Research Articles Source Type: research

Trunk Restraint to Promote Upper Extremity Recovery in Stroke Patients: A Systematic Review and Meta-Analysis
Conclusion. Trunk restraint has a moderate effect on reduction of upper extremity impairment in chronic stroke patients, in terms of FMA-UE score, increased shoulder flexion, and reduction in excessive trunk movement during reaching. There is insufficient evidence to demonstrate that trunk restraint improves upper extremity function and reaching trajectory smoothness and straightness in chronic stroke patients. Future research on stroke patients at different phases of recovery and with different levels of upper extremity impairment is recommended.
Source: Neurorehabilitation and Neural Repair - August 13, 2014 Category: Neurology Authors: Wee, S. K., Hughes, A.-M., Warner, M., Burridge, J. H. Tags: Clinical Research Articles Source Type: research

Caregiver-Mediated Intervention Can Improve Physical Functional Recovery of Patients With Chronic Stroke: A Randomized Controlled Trial
Conclusion. CHI can improve physical functional recovery and, possibly, social participation in patients with chronic stroke.
Source: Neurorehabilitation and Neural Repair - December 10, 2014 Category: Neurology Authors: Wang, T.-C., Tsai, A. C., Wang, J.-Y., Lin, Y.-T., Lin, K.-L., Chen, J. J., Lin, B. Y., Lin, T. C. Tags: Clinical Research Articles Source Type: research

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