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Association of Myomectomy With Anti-M üllerian Hormone Levels and Ovarian Reserve
CONCLUSION: Myomectomy is associated with a transient decline in AMH levels in the immediate postoperative period, particularly after open surgery in which a tourniquet is used. Anti-müllerian hormone levels returned to baseline by 3 months after surgery, indicating that myomectomy is not associated with a long-term effect on ovarian reserve, even with the use of a tourniquet to decrease blood loss.FUNDING SOURCE: This study was funded in part by a Roche Diagnostics Investigator-Initiated Study Grant.PMID:36441930 | DOI:10.1097/AOG.0000000000004983
Source: Obstetrics and Gynecology - November 28, 2022 Category: OBGYN Authors: Devora Aharon Lucky Sekhon Chloe Getrajdman Mackenzie Naert William Hanley Ahmad Kerr Atoosa Ghofranian Carlos Hernandez-Nieto Joseph A Lee Alan Copperman Charles Ascher-Walsh Source Type: research

Challenge to the Intestinal Mucosa During Sepsis
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with ...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Obesity-Related Epigenetic Changes After Bariatric Surgery
Conclusions: Bariatric surgery appears to be capable of partially reversing the obesity-related epigenome. The identification of potential epigenetic biomarkers predictive for the success of bariatric surgery may open new doors to personalized therapy for severe obesity. Introduction Obesity is currently a huge healthcare problem, worldwide, and is a risk factor for several diseases such as type 2 diabetes (T2D), cardiovascular disease and cancer (1). As the prevalence of obesity reaches pandemic proportions, this metabolic disease is estimated to become the biggest cause of mortality in the near future (2). In fact,...
Source: Frontiers in Endocrinology - April 15, 2019 Category: Endocrinology Source Type: research

24 Microwave ablation therapy for hepatocellular carcinoma
ConclusionsMAT has gained recognition in the treatment of early or advanced HCC. With the development of image guidance, multiple innovative instruments and different combination therapy modalities, MAT is a promising therapy for development and clinical application in the future.AcknowledgmentsThis research was financially supported by Sichuan University (Grant No. 2016SCU11033).
Source: Journal of Investigative Medicine - December 18, 2016 Category: Research Authors: Yang, N., Guan, Y., He, Q., Xiong, F. Tags: Healthcare Informatics Source Type: research

Occult microscopic endometriosis: undetectable by laparoscopy in normal peritoneum
STUDY QUESTION Is there any occurrence of hidden (occult) endometriotic lesions in normal peritoneum of women with and without visible endometriosis? SUMMARY ANSWER We detected a slightly higher occurrence of occult microscopic endometriosis (OME) in normal peritoneum of women with visible endometriosis than in control women. WHAT IS KNOWN ALREADY Based on a small number of cases, the concept of invisible microscopic endometriosis in visually normal peritoneum has been reported for more than a decade but there is controversy regarding their tissue activity and clinical significance. STUDY DESIGN, SIZE, DURATION This cas...
Source: Human Reproduction - February 13, 2014 Category: Reproduction Medicine Authors: Khan, K. N., Fujishita, A., Kitajima, M., Hiraki, K., Nakashima, M., Masuzaki, H. Tags: Gynaecology Source Type: research