Obesity-Related Epigenetic Changes After Bariatric Surgery

Conclusions: Bariatric surgery appears to be capable of partially reversing the obesity-related epigenome. The identification of potential epigenetic biomarkers predictive for the success of bariatric surgery may open new doors to personalized therapy for severe obesity. Introduction Obesity is currently a huge healthcare problem, worldwide, and is a risk factor for several diseases such as type 2 diabetes (T2D), cardiovascular disease and cancer (1). As the prevalence of obesity reaches pandemic proportions, this metabolic disease is estimated to become the biggest cause of mortality in the near future (2). In fact, it is extremely alarming, given that 2.3% of men and 5.0% of women have a body mass index (BMI) ≥35 kg/m2. The worldwide prevalence of morbid obesity was reported to be 0.64% in men and 1.6% in women (3). Obesity is a multifaced chronic disease, the cause of which is a disbalance between energy consumed and the energy burned off. This disbalance is promoted by several factors such as unhealthy diet, sedentarism, and genotype (4). As consequence, surplus energy is stored in the adipocytes, and leading to an adipose tissue dysfunction characteristic of obesity, as well as other metabolic disorders, such as alterations in insulin sensitivity, blood pressure and the plasma lipid profile, which are risk factors that together define metabolic syndrome (5). Abdominal obesity is a powerfully risk factor of cardiovascular disease and T2D, independently of BMI (6...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research

Related Links:

ConclusionsBy discussing various heterogeneity statistics, visualizations, and explanatory methods, this article provides the applied developmental researcher a foundational understanding of complexity and heterogeneity in meta-analysis.
Source: Journal of Adolescence - Category: Child Development Source Type: research
CONCLUSIONS: Considering the age group in which rectal prolapse is most commonly seen, and the change in bowel habits, chronic constipation and irritation chronic seen in rectal prolapse may be responsible for the development of rectum cancer, therefore endoscopic screening should not be overlooked in rectal prolapse cases. KEY WORDS: Anorectal emergencies, Colon cancer, Rectal prolapse. PMID: 31723051 [PubMed - in process]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
CONCLUSION: The etiology of chronic groin pain post hernia repair is related in part to nerve injury. This is supported by the high frequency of sensory symptoms and numbness in these patients. However other factors including the role of tissue injury and inflammatory postoperative changes need to be considered. KEY WORDS: Chronic postoperative pain, Inguinal hernia repair, Open surgery, Laparoscopic surgery. PMID: 31719216 [PubMed - as supplied by publisher]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
Conclusion: Most nonthermal physical treatments are unable to sterilize thoroughly, thereby resulting in suppressed or sublethally injured microbial cells instead of killing them completely. This poses food safety hazards since microorganisms may re-grow at post-processing stage as favorable conditions are available again. Studying the mechanism of these responses on microorganisms may help us to do better in anticipating possible risks during food processing and preventing potential food safety incidents.
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
ConclusionsNatural active food-derived ingredients are marketed as having several benefits on the skin. Their incorporation in food supplements and cosmetics is a reality already marketed. The truth about the benefits of food ingredients in cosmetics is not always properly discussed. The trend of “beauty from within” by oral supplementation is now accompanying the other trend that is “from the kitchen table to the skin”, that refers to the possibility to create cosmetics with the ordinary ingredients one have in the kitchen.Graphical abstract
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 15 November 2019Source: Trends in Food Science &TechnologyAuthor(s): M.A. Augustin, L. Sanguansri, E.M. Fox, L. Cobiac, M.B. ColeAbstractBackgroundFruits and vegetables are an excellent source of nutrients, with numerous health benefits. Most consumers are not meeting the daily recommended intake of fruits and vegetables. Yet, a significant amount of fruits and vegetables that is produced is wasted. There are opportunities to recover the wasted fruits and vegetables for manufacturing value-added products to improve the sustainability of healthy diets and reduce the environmental footp...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 15 November 2019Source: Trends in Food Science &TechnologyAuthor(s): Ryoiti KiyamaAbstractBackgroundGreen tea is produced from the tea plant Camellia sinensis without fermentation, and contains characteristic constituents, which are associated with health-promoting effects such as physiological, immunological, neurological and psychological effects, and protective effects against diseases, such as cancer, cardiovascular diseases and diabetes. Catechins, such as catechin, epicatechin, epigallocatechin, epicatechin-3-O-gallate and epigallocatechin-3-O-gallate, and other green tea consti...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
CONCLUSIONS: Both STX3451 and STX2895 provide new approaches for inducing cell death and lowering tumour burden in NF2 as well as in NF1, which both have limited treatment options. PMID: 31730023 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
CONCLUSIONS: The matrices and the questionnaire have a great diagnostic performance which seems interesting for a use as a screening tool for occupational exposures. These results have yet to be confirmed by large-scale studies. PMID: 31727556 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
The objective of this paper is to synthesise current knowledge on ALK rearrangement and its impact on the management of advanced NSCLC. Several inhibitors of the tyrosine kinase of ALK (crizotinib, ceritinib, alectinib) have been approved as first line therapies in patients with advanced ALK positive NSCLC, which are associated with a better median progression-free survival than conventional chemotherapy. Unfortunately, the emergence of drug resistance leads to tumor progression. In patients with oligoprogressive disease if local ablative therapy can be effected, continuing with the same ALK tyrosine kinase inhibitor is on...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
More News: Acute Leukemia | Acute Myeloid Leukemia | Alcoholism | Allergy & Immunology | Bariatric Surgery | Biology | Biotechnology | Brain | Brain Cancers | Breast Cancer | Breast Carcinoma | Burns | Cancer | Cancer & Oncology | Cancer in Adolescents | Carcinoma | Cardiology | Cardiovascular | Cardiovascular & Thoracic Surgery | Chemistry | Child Development | Children | Chronic Leukemia | Colorectal Cancer | Congestive Heart Failure | Diabetes | Diabetes Mellitus | Diabetes Type 1 | Diabetes Type 2 | Diets | Eating Disorders & Weight Management | Endocrinology | Environmental Health | Fatty Liver Disease (FLD) | Gastrectomy | Gastric (Stomach) Cancer | Gastric Bypass | Gastroenterology | Genetics | Grants | Heart | Heart Failure | Hepatocellular Carcinoma | High Fat | Hormones | Hypertension | Incretin Therapy | Insulin | Laparoscopy | Leukemia | Liver | Liver Cancer | Liver Disease | Men | Menopause | Metabolic Syndrome | Middle East Health | Mitochondrial Disease | Molecular Biology | Neurology | Neuroscience | Neurosurgery | Non-alcoholic Fatty Liver Diseases (NAFLD) | Nutrition | Obesity | Pandemics | Physiology | Psychology | Science | Spain Health | Sports Medicine | Study | Toxicology | Urology & Nephrology | Weight Loss | Women