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Stroke patients ’ support: evaluation of knowledge, practices and training needs of French community pharmacists
Conclusion Based on this small study, the fragmented knowledge and varied practices promote the need for further training for pharmacists to optimize support of stroke patients. This study promotes the elaboration of training systems adapted to pharmacists ’ needs. This will help support the development of a targeted pharmaceutical care approach for stroke patients.
Source: International Journal of Clinical Pharmacy - August 1, 2021 Category: Drugs & Pharmacology Source Type: research

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer ’s Disease Through Activation of BDNF-TrkB Signaling Pathway
Conclusion The data in this manuscript demonstrates that apelin-13 upregulates BDNF against STZ-induced congnitive impairment by suppressing glial cell activity and inflammatory factors release. This suggests apelin signaling may be a new target in the treatment of AD. Ethics Statement All experimental protocols were carried out according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals approved by the Central South University at XiangYa Animal Care and Use Committee. Author Contributions XqQ and LH conceived the study and contributed to its experimental design. HqL carried out the...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

The Association Between Type 2 Diabetes and Cardiovascular Disease: The “For Your SweetHeart™” Survey
ConclusionsFindings indicate that education regarding the association between T2DM and CVD in patients and their loved ones is warranted.Plain Language SummaryPlain language summary available for this article. Please see Fig. 1 and the following link:https://doi.org/10.6084/m9.figshare.7546817.FundingThe “For Your SweetHeart™” survey was supported by the Boehringer Ingelheim& Eli Lilly and Company Diabetes Alliance, and was developed in partnership with KRC Research.
Source: Advances in Therapy - February 13, 2019 Category: Drugs & Pharmacology Source Type: research

Therapeutic Advances in the Management of Orthostatic Hypotension
Conclusions: Although there is no accepted protocol regarding how to manage hypertension in patients with OH, some studies favor the use of beta blockers and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, over alpha-receptor antagonists and diuretics.
Source: American Journal of Therapeutics - January 1, 2018 Category: Drugs & Pharmacology Tags: Systematic Review and Clinical Guidelines Source Type: research