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Drug: Nicotine
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Total 343 results found since Jan 2013.

Stress effects on spatial memory retrieval and brain c-Fos expression pattern in adults are modulated by early nicotine exposure
Neurobiol Learn Mem. 2023 Sep 18:107831. doi: 10.1016/j.nlm.2023.107831. Online ahead of print.ABSTRACTThe cognitive effects of nicotine are linked to persistent modifications in extended neural systems that regulate cognitive and emotional processes, and these changes occur during development. Additionally, acute stress has modulatory effects on cognition that involve broad neural systems and can be influenced by prior environmental challenges. The effects of nicotine and stress may be interconnected, leading to modifications in a network of shared brain substrates. Here, we explored the interaction between nicotine and s...
Source: Neurobiology of Learning and Memory - September 20, 2023 Category: Neurology Authors: Jos é L Solano Carlos Novoa Marisol R Lamprea Leonardo A Ortega Source Type: research

Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Demystifying the impact of prenatal tobacco exposure on the placental immune microenvironment: Avoiding the tragedy of mending the fold after death
This study aims to meticulously examine the repercussions of PTE on placental immune landscapes, employing a coordinated research methodology encompassing bioinformatics, machine learning and animal studies. Concurrently, it aims to screen biomarkers and potential compounds that could sensitively indicate and mitigate placental immune disorders. In the course of this research, two gene expression omnibus (GEO) microarrays, namely GSE27272 and GSE7434, were included. Gene set enrichment analysis (GSEA) and immune enrichment investigations on differentially expressed genes (DEGs) indicated that PTE might perturb numerous inn...
Source: J Cell Mol Med - September 13, 2023 Category: Molecular Biology Authors: Xiaoxuan Zhao Yuepeng Jiang Xiao Ma Qujia Yang Xinyi Ding Hanzhi Wang Xintong Yao Linxi Jin Qin Zhang Source Type: research

Preliminary study on the E-liquid and aerosol on the neurobehavior of C. elegans
This study can provide new ideas for future studies on the neurotoxic effects and safety assessment of the E-cigarettes, and provide theoretical reference for the study on the injury mechanism of E-cigarettes.PMID:37690220 | DOI:10.1016/j.envint.2023.108180
Source: Environment International - September 10, 2023 Category: Environmental Health Authors: Yanting Pang Menghan Li Fuxian Li Jialin Lei Ting Zhang Source Type: research

Correlates of adolescent sole-, dual- and poly-use of cannabis, vaped nicotine, and combusted tobacco
CONCLUSION: Different sets of correlates were associated with sole-, dual-, and poly-use, suggesting that certain adolescents may be more vulnerable than others to multiple substance use. Future research should examine potentially modifiable upstream influences, such as the home environment and socioeconomic factors that may affect the relationship between adolescent mental health, school performance, and multiple addictive substance use.PMID:37478525 | DOI:10.1016/j.addbeh.2023.107804
Source: Addictive Behaviors - July 21, 2023 Category: Addiction Authors: Jessica Liu Andy S L Tan Jonathan P Winickoff Vaughan W Rees Source Type: research

Surgical residents as "second victims" following exposure to medical errors in a tertiary health training facility in Nigeria: a phenomenology study
CONCLUSION: The "second victim" phenomenon was common among the study group with consequent negative effects. Normalizing discussions about medical errors, reduction of work hours and meticulous intraoperative guidance may reduce medical errors and its consequences on the surgical residents. Steps should be taken within the system to address this issue effectively.PMID:37464356 | DOI:10.1186/s13037-023-00370-z
Source: Patient Safety in Surgery - July 18, 2023 Category: Surgery Authors: James Ayokunle Balogun Adefisayo Ayoade Adekanmbi Folusho Mubowale Balogun Source Type: research

Modeled Rat Hepatic and Plasma Concentrations of Chemicals after Virtual Administrations Using Two Sets of in silico Liver-to-Plasma Partition Coefficients
In this study, two sets of in silico Kp,h values for 14 model substances were assessed using experimentally reported in vivo steady-state Kp,h data and time-dependent virtual internal exposures in the liver and plasma modeled by forward dosimetry in rats. The Kp,h values for 14 chemicals independently calculated using the primary Poulin and Theil method in this study were significantly correlated with those obtained using the updated Rodgers and Rowland method and with reported in vivo steady-state Kp,h data in rats. When pharmacokinetic parameters were derived based on individual in vivo time-dependent data for diazepam, ...
Source: Biological and Pharmaceutical Bulletin - June 28, 2023 Category: Drugs & Pharmacology Authors: Koichiro Adachi Masayoshi Utsumi Tasuku Sato Hina Nakano Makiko Shimizu Hiroshi Yamazaki Source Type: research