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Drug: Methamphetamine

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Total 85 results found since Jan 2013.

Comment: Association or causation measures in racial disparities
Racial and ethnic disparities are well established in every subtype of stroke. An understudied group is Native Hawaiian/Pacific Islanders (NHOPI); the accompanying article by Nakagawa et al.1 expands our knowledge about disparities involving NHOPI. Their results indicate a higher proportion of intracerebral hemorrhage (ICH) and methamphetamine-related ICH among NHOPI as compared to whites and Asians. While the numbers seem compelling, it is worth reviewing the methods and measures of association.
Source: Neurology - March 9, 2015 Category: Neurology Authors: Cruz-Flores, S., Woo, D. Tags: Cohort studies, Risk factors in epidemiology, Intracerebral hemorrhage ARTICLE Source Type: research

Methamphetamine use is an independent predictor of poor outcome after aneurysmal subarachnoid hemorrhage
Conclusions Methamphetamine users have significantly worse outcomes at 1 and 3 years following aSAH. Further analysis is necessary to understand the pathological response associated with methamphetamine use in this setting.
Source: Journal of NeuroInterventional Surgery - April 13, 2015 Category: Neurosurgery Authors: Moon, K., Albuquerque, F. C., Mitkov, M., Ducruet, A. F., Wilson, D. A., Crowley, R. W., Nakaji, P., McDougall, C. G. Tags: Hemorrhagic stroke Source Type: research

Ibudilast reverses the decrease in the synaptic signaling protein phosphatidylethanolamine-binding protein 1 (PEBP1) produced by chronic methamphetamine intake in rats*
Methamphetamine is a potent psychostimulant drug which has been gaining popularity worldwide (United Nations Office on Drugs and Crime, 2009). From a pathological standpoint, chronic methamphetamine abuse has devastating effects on the neural system and predisposes people to movement disorders, stroke, seizures, aggressiveness, memory deficits, and psychosis (Hsieh et al., 2014; Panenka et al., 2013; Yamamoto et al., 2010). These changes can remain for years after discontinued use and may reflect risk factors for relapse (Grant et al., 2012; Scott et al., 2007).
Source: Drug and Alcohol Dependence - April 29, 2015 Category: Addiction Authors: Sergios Charntikov, Steven T. Pittenger, Ishwor Thapa, Dhundy R. Bastola, Rick A. Bevins, Gurudutt Pendyala Tags: Full length article Source Type: research

Methamphetamine induces the release of endothelin
This study investigates the effect of methamphetamine on endothelin‐1 (ET‐1) release in mouse brain endothelial cells by ELISA. ET‐1 transcription as well as endothelial nitric oxide synthase (eNOS) activation and transcription were measured following methamphetamine treatment. We also examine the effect of methamphetamine on isolated cerebral arteriolar vessels from C57BL/6 mice. Penetrating middle cerebral arterioles were cannulated at both ends with a micropipette system. Methamphetamine was applied extraluminally, and the vascular response was investigated. Methamphetamine treatment of mouse brain endothelial cel...
Source: Journal of Neuroscience Research - November 17, 2015 Category: Neuroscience Authors: Jeong‐Woo Seo, Susan M. Jones, Trisha A. Hostetter, Jeffrey J. Iliff, G. Alexander West Tags: Research Article Source Type: research

E-cigarettes: Good news, bad news
Follow me at @JohnRossMD Americans are confused about electronic cigarettes. A recent poll showed that the public was about evenly split between those who thought that electronic cigarettes, or e-cigarettes, were less harmful than conventional cigarettes, and those who believed that e-cigarettes were as bad as or worse than regular cigarettes. Unfortunately, there is no long-term safety data about e-cigarettes. What information we do have suggests that e-cigarettes have a complex mix of potential harms and benefits. E-cigarettes: Less deadly than regular cigarettes First, the good news: e-cigarettes are almost certainly le...
Source: New Harvard Health Information - July 25, 2016 Category: Consumer Health News Authors: John Ross, MD, FIDSA Tags: Behavioral Health Cancer Lung disease Prevention Smoking cessation Source Type: news

Melatonin as an Antioxidant: Under Promises but Over Delivers
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - August 7, 2016 Category: Research Authors: Russel J. Reiter, Juan C. Mayo, Dun ‐Xian Tan, Rosa M. Sainz, Moises Alatorre‐Jimenez, Lilian Qin Tags: Review Source Type: research

Methamphetamine-related brainstem haemorrhage
We report the case of an otherwise healthy 29-year-old woman who presented with a brainstem haemorrhage following intravenous methamphetamine use. Extensive investigation did not reveal an underlying pathology, and the development of symptoms was temporally related to methamphetamine injection. Although intracerebral haemorrhage secondary to methamphetamine use is well documented, this report describes a haemorrhage within the brainstem which is a rare location. While animal studies have demonstrated the potential of methamphetamines to produce brainstem haemorrhages, there has only been one previous report describing a ha...
Source: Journal of Clinical Neuroscience - August 31, 2016 Category: Neuroscience Source Type: research

Impaired arterial smooth muscle cell vasodilatory function in methamphetamine users
This study was designed to evaluate arterial function and structure in methamphetamine users ultrasonographically.Methods: In a cross-sectional study, 20 methamphetamine users and 21 controls, aged between 20 and 40years, were enrolled. Common carotid artery intima-media thickness (CCA-IMT) marker of early atherogenesis, flow-mediated dilatation (FMD) determinants of endothelium –dependent vasodilation, and nitroglycerine-mediated dilatation (NMD) independent marker of vasodilation were measured in two groups.
Source: Journal of the Neurological Sciences - September 16, 2016 Category: Neurology Authors: Ghaemeh Nabaei, Shahram Oveis Gharan, Askar Ghorbani, Farzad Fatehi Source Type: research

Postepy Hig Med Dosw 2017; 71:137-148 "Ibudilast: a non ‑ selective phosphodiesterase inhibitor in brain disorders"
Ibudilast (IBD) is a non ‑ selective (3, 4, 10, 11) phosphodiesterase (PDE) inhibitor, used mainly as a bronchodilator for the treatment of bronchial asthma. PDE play a central role in cellular function (e.g. differentiation, synaptic plasticity and inflammatory response) by metabolizing cyclic nucleotides. The results from preclinical and clinical studies indicate that IBD has a broader range of action through suppression of pro ‑ inflammatory cytokines (IL ‑ 6, IL ‑ 1 β , TNF ‑ α ), toll ‑ like receptor 4 blockade (TLR ‑ 4), inhibition of a macrophage migration inhibitory factor (MIF), up ‑ regulation t...
Source: Postepy higieny i medycyny doswiadczalnej - March 2, 2017 Category: Research Tags: Review article Source Type: research

Clinical Characteristics, Histopathological Features, and Clinical Outcome of Methamphetamine-Associated Cardiomyopathy
Conclusions MA-associated cardiomyopathy is characterized by severe heart failure and depressed cardiac function. The extent of myocardial fibrosis seems to predict the recoverability of LV function. Cessation of MA abuse is associated with improvement in cardiac function and symptoms, whereas continued MA abuse leads to ongoing heart failure and worse outcome. Graphical abstract
Source: JACC: Heart Failure - May 30, 2017 Category: Cardiology Source Type: research

Doing meth raises the risk of strokes in young people
Strokes aren ’t common under the age of 45, but people who use methamphetamine are almost five times more likely to have a type of stroke that can be fatal
Source: New Scientist - Health - August 23, 2017 Category: Consumer Health News Source Type: research

Meth Use Tied to Higher Risk of Stroke in Younger People
Predominately hemorrhagic strokes associated with methamphetamine use
Source: The Doctors Lounge - Psychiatry - August 25, 2017 Category: Psychiatry Tags: Family Medicine, Internal Medicine, Emergency Medicine, Neurology, Nursing, Pathology, Pharmacy, Psychiatry, Journal, Source Type: news

Meth use boosts young adults ’ risk for brain bleeds and stroke
(Reuters Health) - Young adults who use the stimulant methamphetamine, sometimes called `speed, ’ `ice,’ or `meth,’ may have an increased risk of strokes, a recent study suggests.
Source: Reuters: Health - August 30, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

Features and Outcomes of Methamphetamine Associated Pulmonary Arterial Hypertension.
CONCLUSIONS: Meth-APAH is a severe and progressive form of PAH with poor outcomes. Future studies should focus on mechanisms of disease and potential therapeutic considerations. PMID: 28934596 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - September 21, 2017 Category: Respiratory Medicine Authors: Zamanian RT, Hedlin H, Greuenwald P, Wilson DM, Segal JI, Jorden M, Kudelko K, Liu J, Hsi A, Rupp A, Sweatt AJ, Tuder R, Berry GJ, Rabinovitch M, Doyle RL, De Jesus Perez V, Kawut SM Tags: Am J Respir Crit Care Med Source Type: research