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Drug: Melatonin
Nutrition: Vitamins
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Total 191 results found since Jan 2013.
Melatonin or vitamin C attenuates lead acetate-induced testicular oxidative and inflammatory damage in mice by inhibiting oxidative stress mediated NF- κB signaling
In this study, we aimed to determine the effects of lead acetate on reproductive function in male mice, identify the underlying mechanisms, and test counter measures to alleviate the toxic effects. Male mice were dosed with lead acetate (500 mg/L) in free drinking water for 12 weeks, and administered melatonin (5 mg/kg) or vitamin C (500 mg/kg) by intraperitoneal injection. Blood from the eyeball, testicles, and sperm from the caudal epididymis were collected after 12 weeks and analyzed. Pb exposure reduced sperm count and motility, increased sperm malformation (P < 0.01), disrupted testicular morphology and structure, ...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Ze-Min Zhao Su Mei Qi-Yue Zheng Jiao Wang Yi-Ru Yin Jiao-Jiao Zhang Xian-Zhong Wang Source Type: research
Melatonin reduced colon inflammation but had no effect on energy metabolism in ageing Mongolian gerbils (Meriones unguiculatus)
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Aug 21:109731. doi: 10.1016/j.cbpc.2023.109731. Online ahead of print.ABSTRACTIn photoperiod-sensitive wild animals, the secretion of melatonin (MT) is modulated by external photoperiod, and MT affects inflammation and the ageing process. The beneficial effects of MT in delaying the progress of ageing have been reported in laboratory mice and rats. However, little is known about MT in wild mammals. In the current study, we investigated energy metabolism, microbial community structure and colon homeostasis in ageing Mongolian gerbils (Meriones unguiculatus) through exogenous su...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - August 23, 2023 Category: Biochemistry Authors: Wen-Ting Gao Jin-Xiu Liu De-Hua Wang Hai-Ji Sun Xue-Ying Zhang Source Type: research
Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging
Arch Toxicol. 2023 Aug 19. doi: 10.1007/s00204-023-03562-9. Online ahead of print.ABSTRACTA physiological level of oxygen/nitrogen free radicals and non-radical reactive species (collectively known as ROS/RNS) is termed oxidative eustress or "good stress" and is characterized by low to mild levels of oxidants involved in the regulation of various biochemical transformations such as carboxylation, hydroxylation, peroxidation, or modulation of signal transduction pathways such as Nuclear factor-κB (NF-κB), Mitogen-activated protein kinase (MAPK) cascade, phosphoinositide-3-kinase, nuclear factor erythroid 2-related factor ...
Source: Archives of Toxicology - August 19, 2023 Category: Toxicology Authors: Klaudia Jomova Renata Raptova Suliman Y Alomar Saleh H Alwasel Eugenie Nepovimova Kamil Kuca Marian Valko Source Type: research
Effects of the Melatonin and Vitamin E (Alpha-Tocopherol Acetate) as Antioxidants on Biochemical Blood Parameters, Lipid Profile, and Muscle Vitamin E Concentration in Awassi Lambs Fed a High-Energy Diet and Normal Diet
Arch Razi Inst. 2023 Feb 28;78(1):249-259. doi: 10.22092/ARI.2022.358494.2234. eCollection 2023 Feb.ABSTRACTHealth specialists currently suggest low-cholesterol diets, suggesting that cholesterol in the form of high-density lipoprotein (HDL) reduces the risk of chronic atherosclerosis. The large volume of literature describes the biological roles of vitamin E and its application to preventing disease and improving the health and productive performances of farm animals. The present study aimed to evaluate the effects of vitamin E (Alpha-tocopherol acetate) supplementation and melatonin implants on biochemical blood, lipid p...
Source: Atherosclerosis - June 14, 2023 Category: Cardiology Authors: K Ismail Mahmud F Karada ş Source Type: research
Protective effect of melatonin and ascorbic acid combination on sepsis-induced lung injury: An Experimental study
In conclusion, this study supports the potential synergistic protective effects of MEL and ASA in treating sepsis-induced lung injury. The combination therapy could effectively reduce oxidative stress, inflammation and improve antioxidant capacity in septic rats, suggesting a promising strategy for treating sepsis-induced lung injury.PMID:37199082 | DOI:10.1111/1440-1681.13780
Source: Clinical and Experimental Pharmacology and Physiology - May 18, 2023 Category: Drugs & Pharmacology Authors: Hilal Üstündağ Özlem Demir Bet ül Çiçek Mehmet Tahir Huyut Neslihan Y üce Taha Tavac ı Source Type: research
Disaggregating the effects of daytime and nighttime light exposures on obesity, overweight, prostate and breast cancer morbidity worldwide
In this study, we aim to narrow this knowledge gap by analyzing data available for 100+ countries worldwide, while controlling ALAN and solar radiation exposure estimates by several potential confounders, such as GDPpc, GINI inequality index and unhealthy food consumption. As the study reveals, all the morbidity types under analysis are significantly and positively associated with ALAN exposure estimates (p < 0.05), while solar radiation appears to be significantly associated with prostate cancer rates only (p < 0.05), but not with breast cancer or overweight/obesity rates (p > 0.1). To the best of our knowledge, ...
Source: Chronobiology International - April 4, 2023 Category: Biology Authors: Maram Sirhan-Atalla Nahum M Gabinet Boris A Portnov Source Type: research
Serotonin, melatonin and their precursors and metabolites and vitamin D < sub > 3 < /sub > derivatives in honey
Melatonin Res. 2022 Oct 3;5(3):374-380. doi: 10.32794/mr112500137. Epub 2022 Sep 30.ABSTRACTWe are commenting recent discoveries on the presence of L-DOPA, dopamine, 5-hydroxytryptophan, tryptamine, serotonin, N-acetylserotonin, melatonin, 2-hydroxymelatonin, AFMK and AMK in honey. Serotonin and melatonin, products of the tryptophan metabolism, are widely produced in nature, serving as hormones, neurotransmitters, biological regulators, neurotransmitters and antioxidants, in a context dependent fashion. Dopamine and tryptamine are important neurotransmitters across different species. Honey is used as one of the most popula...
Source: Cell Research - April 3, 2023 Category: Cytology Authors: Tae-Kang Kim Adrian Fabisiak Pawel Brzeminski Russel J Reiter Andrzej T Slominski Source Type: research
Role of Supplements in the Management of COVID-19 - A Comprehensive Review
Infect Disord Drug Targets. 2023 Mar 10. doi: 10.2174/1871526523666230310094646. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) and patients with COVID-19 may be treated primarily with SARS CoV-2-targeting drugs and the therapeutic agents assisting in the management of COVID-19 complications. This review focuses on the supplements like vitamins, minerals, herbal constituents, and others that help prevent or manage negative outcomes among COVID-19 patients. The literature was searched in databases such as Medline/PubMed Central/...
Source: Infectious Disorders Drug Targets - March 10, 2023 Category: Infectious Diseases Authors: Rajkapoor Balasubramanian Naina Mohamed Pakkir Maideen Sudha Muthusamy Sambathkumar Ramanathan Mohamed Harsath Jahir Hussain Source Type: research
