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Drug: Melatonin
Nutrition: High Fat
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Total 63 results found since Jan 2013.
Melatonin ameliorates atherosclerosis by suppressing S100a9-mediated vascular inflammation
Eur J Pharmacol. 2023 Aug 23:175965. doi: 10.1016/j.ejphar.2023.175965. Online ahead of print.ABSTRACTAtherosclerosis (AS)-associated cardiovascular diseases are predominant causes of morbidity and mortality worldwide. Melatonin, a circadian hormone with anti-inflammatory activity, may be a novel therapeutic intervention for AS. However, the exact mechanism is unclear. This research intended to investigate the mechanism of melatonin in treating AS. Melatonin (20 mg/kg/d) was intraperitoneally administered in a high-fat diet (HFD)-induced AS model using apolipoprotein E-deficient (ApoE-/-) mice for 12 weeks. Immunohistochem...
Source: European Journal of Pharmacology - August 25, 2023 Category: Drugs & Pharmacology Authors: Liyuan Chen Xue Wang Chang Liu Ping Deng Lina Pan Lingling Yang Juan Cheng Xutao Zhang Russel J Reiter Zhengping Yu Huifeng Pi Zhou Zhou Houyuan Hu Source Type: research
Melatonin associated with a high-fat diet during pregnancy and lactation prevents liver changes in the offspring
In conclusion, melatonin combined with a high-fat diet preserves the liver architecture and function in the offspring.PMID:37586542 | DOI:10.1016/j.ygcen.2023.114357
Source: General and Comparative Endocrinology - August 16, 2023 Category: Endocrinology Authors: Clovis J C Lapa Neto Ismaela M F de Melo Paloma K B M Alpiovezza Yuri M L de Albuquerque An ísio Francisco Soares Álvaro A C Teixeira Val éria Wanderley-Teixeira Source Type: research
Melatonin modulates the aggravation of pyroptosis, necroptosis, and neuroinflammation following cerebral ischemia and reperfusion injury in obese rats
This study aimed to investigate the roles of melatonin on pyroptosis, necroptosis, and pro-inflammatory pathways occurring in the I/R brain of obese rats. Male Wistar rats were given a high-fat diet for 16 weeks to induce the obese condition, and then were divided into 4 groups: Sham-operated, I/R treated with vehicle, I/R treated with melatonin (10 mg/kg), and I/R treated with glycyrrhizic acid (10 mg/kg). All drugs were administered via intraperitoneal injection at the onset of reperfusion. The development of neurological deficits, cerebral infarction, histological changes, neuronal death, and glial cell hyperactivation ...
Source: Biochimica et Biophysica Acta - June 11, 2023 Category: Biochemistry Authors: Nuttapong Yawoot Jirakhamon Sengking Piyarat Govitrapong Chainarong Tocharus Jiraporn Tocharus Source Type: research
Melatonin attenuates lung ischemia-reperfusion injury through SIRT3 signaling-dependent mitophagy in type 2 diabetic rats
Conclusion: Data indicated that melatonin attenuates diabetic LIRI through activation of SIRT3 signaling-mediated mitophagy.PMID:37265380 | DOI:10.1080/01902148.2023.2213335
Source: Cell Research - June 2, 2023 Category: Cytology Authors: Zhiqiang Song Congmin Yan Yuanbo Zhan Qiujun Wang Yina Zhang Tao Jiang Source Type: research
Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat
CONCLUSIONS: Combination therapy with melatonin, NMN, and ubiquinol exerted significant cardioprotection and improved mitochondrial function and biogenesis via upregulation of SIRT-1/PGC-1α/NRF-2/TFAM profiles in aged diabetic rats and, thus, offers a promising strategy for providing noticeable cardioprotection against I/R injury also in aged diabetic patients.PMID:36787055 | DOI:10.1007/s11033-022-08189-0
Source: Molecular Biology Reports - February 14, 2023 Category: Molecular Biology Authors: Behnaz Mokhtari Poul Flemming H øilund-Carlsen Leila Chodari Masoud Yasami Reza Badalzadeh Samad Ghaffari Source Type: research
Melatonin inhibits atherosclerosis progression via Galectin-3 downregulation to enhance autophagy and inhibit inflammation
This article is protected by copyright. All rights reserved.PMID:36692032 | DOI:10.1111/jpi.12855
Source: Atherosclerosis - January 24, 2023 Category: Cardiology Authors: Zitong Wang Ziyu Gao Yinghong Zheng Jiayuan Kou Dan Song Xue Yu Bowen Dong Tianzuo Chen Yan Yang Xi Gao Qianxue Wang Ting Ye Wei Yang Xu Zhang Hong Li Liming Yang Source Type: research
Nano-melatonin and-histidine modulate adipokines and neurotransmitters to improve cognition in HFD-fed rats: A formula to study
In this study, obese rat model was established by feeding high fat diet (HFD) composed of 25% fats (soybean oil) for 8 weeks, accompanied by melatonin (10 mg/kg), histidine (780 mg/kg), and combination of both in conventional form and nanoform. At the end of the study, adiposity hormones, neuronal monoamines and amino acids, brain derived neurotrophic factor (BDNF) and zonula occluden-1 (ZO-1) were assessed. HFD feeding resulted in significant weight gain and poor performance on cognitive test. Coadministration of histidine in the nanoform increased the level of ZO-1; an indicator of improving the brain barrier integrity, ...
Source: Biochimie - November 9, 2022 Category: Biochemistry Authors: Heba Ahmed Hegazy Dina M Abo-ElMatty Omar Farid Sami Saleh Maivel H Ghattas Nesreen Nabil Omar Source Type: research
