• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Engineered NanoAlum from aluminum turns cold tumor hot for potentiating cancer metalloimmunotherapy
J Control Release. 2023 Jan 23:S0168-3659(23)00052-4. doi: 10.1016/j.jconrel.2023.01.043. Online ahead of print.ABSTRACTThe poor cancer immunotherapy outcome has been closely related to immunosuppressive tumor microenvironment (TME), which usually inactivates the antitumor immune cells and leads to immune tolerance. Metalloimmunotherapy by supplementing nutritional metal ions into TME has emerged as a potential strategy to activate the tumor-resident immune cells. Herein, we engineered a magnesium-contained nano-aluminum adjuvant (NanoAlum) through hydrolyzing a mixture of Mg(OH)2 and Al(OH)3, which has highly similar comp...
Source: Cancer Control - January 26, 2023 Category: Cancer & Oncology Authors: Yingbo Jia Jing Hu Chaojie Zhu Zijing Li Xinyu Yang Ruitian Liu Linghui Zeng Lingxiao Zhang Source Type: research

Targeting regulatory T cells in gastric cancer: Pathogenesis, immunotherapy, and prognosis
Biomed Pharmacother. 2022 Dec 30;158:114180. doi: 10.1016/j.biopha.2022.114180. Online ahead of print.ABSTRACTGastric cancer (GC) remains one of the most common malignancies worldwide. Despite immune-checkpoint inhibitors (ICIs) has revolutionized cancer treatment and obtained durable clinical responses, only a fraction of GC patients benefit from it. As an important component of T cells, regulatory T cells (Tregs) play a vital role in the pathogenesis of GC, keep a core balance between immune suppression and autoimmunity, and function as predictive biomarkers for prognosis of GC patients. In this review, we discuss the ro...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 31, 2022 Category: Drugs & Pharmacology Authors: Bingyu Wang Zaibo Zhang Wenbo Liu Bibo Tan Source Type: research

Wild-type IDH1 inhibition enhances chemotherapy response in melanoma
CONCLUSIONS: These results demonstrate the clinical potential of wtIDH1 inhibition as a novel and readily available combination treatment strategy for patients with advanced and refractory melanoma. Schematic shows increased wild-type IDH1 expression and activity as an adaptive response to metabolic stress induced by chemotherapy.PMID:36153582 | DOI:10.1186/s13046-022-02489-w
Source: Cell Research - September 24, 2022 Category: Cytology Authors: Mehrdad Zarei Omid Hajihassani Jonathan J Hue Hallie J Graor Alexander W Loftus Moeez Rathore Ali Vaziri-Gohar John M Asara Jordan M Winter Luke D Rothermel Source Type: research

Human CAR NK Cells: A New Non-viral Method Allowing High Efficient Transfection and Strong Tumor Cell Killing
In conclusion, the method of NK cell transfection described in our present study is highly efficient, does not require expensive dedicated structures necessary for viral transduction and avoids possible risks associated with the use of viral vectors. Importantly, it may be applied to NK cells or NK-92 cell line, greatly improving their anti-tumor activity and providing a new NK cell-based platform for new protocols of adoptive immuno-therapy of cancer. Ethics Statement The Ethical Committee of IRCCS Bambino Gesù Pediatric Hospital approved the study (825/2014). Author Contributions TI designed and performed res...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Fight Aging! Newsletter, June 4th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - June 3, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs