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Drug: Magnesium
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Total 248 results found since Jan 2013.
Clinical Reasoning: A 44-year-old woman with headache followed by sudden neurologic decline
A 44-year-old woman with a history of migraines and idiopathic intracranial hypertension presented to the emergency room with 1 day of headache and nausea. She had been otherwise healthy with no sick contacts. She was afebrile without nuchal rigidity, rash, or cardiac murmur, and her neurologic examination was normal. Migraine therapy was initiated with IV prochlorperazine, ketorolac, and magnesium. Two hours later, she developed fever (101.4°F) and confusion, continually stating, "It hurts," but unable to answer questions or follow commands despite an otherwise unremarkable examination. Noncontrast head CT demonstrate...
Source: Neurology - March 25, 2013 Category: Neurology Authors: Berkowitz, A. L., Kimchi, E. Y., Hwang, D. Y., Vaitkevicius, H., Henderson, G. V., Feske, S. K., Chou, S. H.- Y. Tags: Hydrocephalus, Stroke in young adults, Meningitis, Critical care RESIDENT AND FELLOW SECTION Source Type: research
Rate of Change of Carotid Intima‐Media Thickness with Magnesium Administration in Abcc6−/− Mice
Abstract
Pseudoxanthoma elasticum (PXE), caused by mutations in the ABCC6 gene, demonstrates progressive build‐up of calcium phosphate and proteoglycans in the skin, eye, and arteries, and is associated to myocardial infarctions, stroke, blindness, and elevated carotid intima‐media thickness (CIMT). Although CIMT reduction with magnesium (Mg) has been documented in a mouse model for PXE (Abcc6−/−), it is not clear if Mg is effective in humans with PXE to reduce CIMT. To examine this, we calculated the rate of change of CIMT (washout) in 15‐ and 12‐month‐old Abcc6−/− mice fed standard rodent diet with or w...
Source: Clinical and Translational Science - April 19, 2013 Category: Biomedical Science Authors: Erine A. Kupetsky, Fred Rincon, Jouni Uitto Tags: Brief Report Source Type: research
FAST-Mag protocol with or without mild hypothermia (35̊C) does not improve outcome after permanent MCAO in rats.
Abstract
The current study assessed the neuroprotective efficacy of magnesium using a FAST-Mag trial treatment protocol alone, and in combination with mild hypothermia, in Sprague Dawley rats subjected to permanent, middle cerebral artery occlusion (MCAO). Treatment with magnesium (MgSO4.7H2O) consisted of an intravenous loading dose (LD: 360 μmol/kg) and a 24 hour infusion (120 μmol/kg/h), while mild hypothermia at 35̊C was maintained for 24 hours. Treatment groups consisted of animals receiving: i) saline; ii) magnesium LD/infusion at 1.5 h/2.5 h post-MCAO; iii) magnesium LD/infusion at 1.5 h/2.5 h post-...
Source: Magnesium Research - June 28, 2013 Category: Biochemistry Authors: Meloni BP, Cross JL, Brookes LM, Clark VW, Campbell K, Knuckey NW Tags: Magnes Res Source Type: research
Electrolyte imbalance triggering relapse of inflammatory neuropathy
We describe a case of a 71 year old female with a fourteen year history of chronic inflammatory demyelinating polyneuropathy (CIDP) and stable monoclonal gammopathy, normally maintained on three–weekly intravenous immunoglobulin (IVIG) therapy. At her best baseline, she has a normal motor examination and reduced vibration sense only to the ankles. She presented with a four week history of progressive numbness and paresthesiae in all four limbs, reduced balance, a decline in mobility with frequent falls and reduced hand function. The deterioration developed after a week of non–bloody diarrhoea with night sweats ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Keshavan, A., Gandhi, S., Lunn, M., Reilly, M. Tags: Neurogastroenterology, Immunology (including allergy), Drugs: CNS (not psychiatric), Multiple sclerosis, Neuromuscular disease, Peripheral nerve disease, Stroke, Hypertension Association of British Neurologists (ABN) joint meeting with the Royal College Source Type: research
Treating cerebral ischemia-reperfusion injuries with salvianolate
Salvianolic acid B, also called salvia magnesium acetate, is a phenolic acid compound composed of three Danshensu units and one molecule of caffeic acid. Salvianolic acid B exerts strong resistance to oxidative stress and inflammatory reaction, and improves energy metabolism against cerebral ischemia-reperfusion injuries. Dr...
Source: Health News from Medical News Today - October 28, 2013 Category: Consumer Health News Tags: Stroke Source Type: news
Intraoperative Magnesium Administration Does Not Improve Neurocognitive Function After Cardiac Surgery Clinical Sciences
Conclusions—
Magnesium administered intravenously during cardiac surgery does not reduce postoperative cognitive dysfunction.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifier: NCT00041392.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Mathew, J. P., White, W. D., Schinderle, D. B., Podgoreanu, M. V., Berger, M., Milano, C. A., Laskowitz, D. T., Stafford-Smith, M., Blumenthal, J. A., Newman, M. F., for the Neurologic Outcome Research Group (NORG) of The Duke Heart Center, Neurologic Out Tags: Clinical Sciences Source Type: research
What Causes Muscle Weakness?
Discussion
Muscle tone is the slight tension that is felt in a muscle when it is voluntarily relaxed. It can be assessed by asking the patient to relax and then taking the muscles through a range of motion such as moving the wrists, forearm and upper arm. Muscle strength is the muscle’s force against active resistance. Impaired strength is called weakness or paresis. There are 5 levels of muscle strength.
0 = No muscle contraction detected
1 = Barely detected flicker of contraction
2 = Active movement with gravity eliminated
3 = Active movement against gravity
4 = Active movement against gravity and some resistance
...
Source: PediatricEducation.org - December 9, 2013 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Mitochondrial Dysfunction in Migraine
Migraine is the most frequent type of headache in children. In the 1980s, scientists first hypothesized a connection between migraine and mitochondrial (mt) disorders. More recent studies have suggested that at least some subtypes of migraine may be related to a mt defect. Different types of evidence support a relationship between mitochondria (mt) and migraine: (1) Biochemical evidence: Abnormal mt function translates into high intracellular penetration of Ca2+, excessive production of free radicals, and deficient oxidative phosphorylation, which ultimately causes energy failure in neurons and astrocytes, thus triggering ...
Source: Seminars in Pediatric Neurology - September 1, 2013 Category: Neurology Authors: William R. Yorns, H. Huntley Hardison Source Type: research
Heme iron intake and acute myocardial infarction: A prospective study of men
Conclusions: Findings from this prospective study indicate that a high heme iron intake, particularly with simultaneous low intake of minerals that can decrease iron absorption, may increase the risk of fatal AMI.
Source: International Journal of Cardiology - January 22, 2014 Category: Cardiology Authors: Joanna Kaluza, Susanna C. Larsson, Niclas Håkansson, Alicja Wolk Tags: Original Articles Source Type: research
Letter by Derakhshan Regarding Article, "Intraoperative Magnesium Administration Does Not Improve Neurocognitive Function Following Cardiac Surgery" Letters to the Editor
Source: Stroke - February 24, 2014 Category: Neurology Authors: Derakhshan, I. Tags: Other Research Letters to the Editor Source Type: research
Response to Letter Regarding Article, "Intraoperative Magnesium Administration Does Not Improve Neurocognitive Function After Cardiac Surgery" Letters to the Editor
Source: Stroke - February 24, 2014 Category: Neurology Authors: Mathew, J. P., Laskowitz, D. T., Newman, M. F. Tags: Behavioral/psychosocial - CV surgery Letters to the Editor Source Type: research
What is the best strategy for successful bowel preparation under special conditions?
Abstract
Adequate bowel preparation is important for successful colonoscopic examination. Several effective colonic cleansing agents are available and routinely prescribed, but each carries its own limitations and benefits from particular dosing regimens. The most frequently prescribed colonic cleansing agent, the polyethylene glycol (PEG) cathartic solution, suffers from low patient compliance in general, due to its unpalatable taste and smell coupled with the large ingested volumes required. However, PEG is preferred over other cathartics for use in individuals of advanced age, sufferers of chronic kidney diseas...
Source: World Journal of Gastroenterology : WJG - March 21, 2014 Category: Gastroenterology Authors: Lim YJ, Hong SJ Tags: World J Gastroenterol Source Type: research
Validation of the ICH Score in Hyperacute Intracerebral Hemorrhage (S25.004)
Conclusions: In the hyperacute setting, all patients with ICH score >=4 had poor outcome. Less than 10%of the patients with an ICH score >=2 had a good outcome.Disclosure: Dr. Bulic has nothing to disclose. Dr. Sanossian has received personal compensation for activities with Boehringer-Ingelheim Pharmaceutical Inc. Dr. Starkman has received research support from the National Institutes of Health, Lundbeck, Mitsubishi, and NTI. Dr. Liebeskind has received personal compensation for activities with Concentric Medical, Inc. and CoAxia, Inc. Dr. Villablanca has nothing to disclose. Dr. Hamilton has nothing to disclose. Dr...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Bulic, S., Sanossian, N., Starkman, S., Liebeskind, D., Villablanca, P., Hamilton, S., Conwit, R., Saver, J. Tags: Cerebrovascular Disease and Interventional Neurology: Hemorrhage, Aneurysms, and Vascular Malformations Source Type: research
Brits eating too much salt, sugar and fat
“Too much sugar, salt and fat: healthy eating still eluding many Britons,” The Guardian reports, while the Daily Mail rather bizarrely warns of a “fruit juice timebomb”. Both papers are covering a major survey that looked at the nation’s eating habits over recent years.The survey found that, overall, adults and children are eating too much saturated fat, added sugar and salt. We are also not getting the recommended levels of fruit, vegetables, oily fish and fibre that our bodies need. Who produced the survey?Public Health England, an agency of the Department of Health, has released data from the National Diet an...
Source: NHS News Feed - May 15, 2014 Category: Consumer Health News Tags: Food/diet QA articles Source Type: news
P-119 * different measures to prevent atrial fibrillation in patients undergoing pulmonary resection for lung cancer: evidence from a comprehensive network meta-analysis of randomized and observational studies
Conclusions: Beta-blockers and flecainide are effective in reducing the incidence of postoperative AF in patients after pulmonary resections which is not the case with digoxin; data on remaining treatments are sparse and preclude drawing definite conclusions.
Disclosure: No significant relationships.
Source: Interactive CardioVascular and Thoracic Surgery - June 9, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Kowalewski, M., Lewandowska, M. A., Kowalewski, J. Tags: SESSION VII: MODERATED POSTERS Source Type: research
