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Acute hepatitis of unknown etiology in an adult female: A case report
CONCLUSION: Idiopathic hepatitis makes treatment challenging. It can leave patients feeling confused and unfulfilled. Thus, educating the patient thoroughly for shared decision-making and management becomes essential.PMID:37621598 | PMC:PMC10445075 | DOI:10.12998/wjcc.v11.i22.5288
Source: Herpes - August 25, 2023 Category: Infectious Diseases Authors: Lucinda Dass Alexandra Marie Malabanan Pacia Mahgol Hamidi Source Type: research

IJERPH, Vol. 19, Pages 16736: Burden of Neurological Diseases in the Philippines as Revealed by Web Searches: An Infodemiological Study
This study evaluated the population’s interest in neurological disorders by using search volumes related to neurology, either disease diagnosis or medications. Bid values generated in API were used as a proxy for the interests of the healthcare industry. Spearman’s rank-order correlation was performed between search volumes and bid prices to determine significance. Among the neurologic diseases listed, the most searched were attention deficit hyperactivity disorder, migraine, and Alzheimer’s disease. The most commonly searched drugs were oral antihypertensives (amlodipine, losartan...
Source: International Journal of Environmental Research and Public Health - December 13, 2022 Category: Environmental Health Authors: Anisah Hayaminnah D. Alonto Almira Doreen Abigail O. Apor Roland Dominic G. Jamora Tags: Article Source Type: research

Evaluation of lens opacity due to inhibition of cholesterol biosynthesis using rat lens explant cultures
In conclusion, we demonstrated that rat lens explant cultures can be useful to assess the potential drug-induced lens opacity associated with inhibition of cholesterol biosynthesis and to elucidate the mechanisms of lens opacity.PMID:34890705 | DOI:10.1016/j.tox.2021.153064
Source: Toxicology - December 10, 2021 Category: Toxicology Authors: Taishi Miyashita Masanori Senshu Kanata Ibi Hiroyuki Yamanaka Hiroaki Nejishima Tatsuki Fukami Miki Nakajima Source Type: research

Pharmacogenetic predictors of cannabidiol (CBD) response and tolerability in treatment-resistant epilepsy
Clin Pharmacol Ther. 2021 Aug 31. doi: 10.1002/cpt.2408. Online ahead of print.ABSTRACTIn patients with treatment-resistant epilepsy (TRE), cannabidiol (CBD) produces variable improvement in seizure control. Patients in the University of Alabama at Birmingham CBD Expanded Access Program (EAP) were enrolled in the genomic study and genotyped using the Affymetrix Drug Metabolizing Enzymes and Transporters plus array. Associations between variants and CBD response (≥50% seizure reduction) and tolerability (diarrhea, sedation, abnormal liver function) was evaluated under dominant and recessive models. Expression quantitative...
Source: Clinical Pharmacology and Therapeutics - August 31, 2021 Category: Drugs & Pharmacology Authors: Brittney H Davis T Mark Beasley Michelle Amaral Jerzy P Szaflarski Tyler Gaston Leslie Perry Grayson David G Standaert E Martina Bebin Nita A Limdi UAB CBD Study Group (includes all the investigators involved in the UAB EAP CBD program) Source Type: research

The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis
Coronavirus disease 2019 (COVID-19) pandemic is caused by the novel coronavirus that has spread rapidly around the world, leading to high mortality because of multiple organ dysfunction; however, its underlying molecular mechanism is unknown. To determine the molecular mechanism of multiple organ dysfunction, a bioinformatics analysis method based on a time-order gene co-expression network (TO-GCN) was performed. First, gene expression profiles were downloaded from the gene expression omnibus database (GSE161200), and a TO-GCN was constructed using the breadth-first search (BFS) algorithm to infer the pattern of changes in...
Source: Frontiers in Immunology - August 24, 2021 Category: Allergy & Immunology Source Type: research

Occurrence and ecological risk assessment of pharmaceuticals and cocaine in the urban drainage channels of Santos beaches (S ão Paulo, Brazil): a neglected, but sensitive issue
This study provides valuable information to reinforce the importance of a continuous monitoring of the diffuse loads (containing PPCPs and illicit drugs) flowing to the coastal zones in developing countries.PMID:34322794 | DOI:10.1007/s11356-021-15249-8
Source: Environmental Science and Pollution Research International - July 29, 2021 Category: Environmental Health Authors: Vinicius Roveri Luciana Lopes Guimar ães Walber Toma Alberto Teodorico Correia Source Type: research

Effects of systemic medication on root resorption associated with orthodontic tooth movement: a systematic review of animal studies.
Conclusions: The pharmaceutical substances investigated were shown to exhibit variable effects on root resorption. Although the overall quality of evidence provides the clinician with a cautious perspective on the strength of the relevant recommendations, good practice would suggest that it is important to identify patients consuming medications and consider the possible implications. Registration: PROSPERO (CRD42017078208). PMID: 29992228 [PubMed - as supplied by publisher]
Source: European Journal of Orthodontics - July 9, 2018 Category: Dentistry Authors: Makrygiannakis MA, Kaklamanos EG, Athanasiou AE Tags: Eur J Orthod Source Type: research

Effects of systemic medication on root resorption associated with orthodontic tooth movement: a systematic review of animal studies
ConclusionsThe pharmaceutical substances investigated were shown to exhibit variable effects on root resorption. Although the overall quality of evidence provides the clinician with a cautious perspective on the strength of the relevant recommendations, good practice would suggest that it is important to identify patients consuming medications and consider the possible implications.RegistrationPROSPERO (CRD42017078208)
Source: The European Journal of Orthodontics - July 9, 2018 Category: Dentistry Source Type: research

Pipe Dreams: Tapping into the Health Information in Our Sewers
The emerging field of sewage chemical-information mining is taking advantage of a readily available yet underappreciated resource: the untreated waste flowing under our feet and the biosolids remaining after treatment. It turns out that sewage and sewage sludge hold a wealth of data on chemical consumption and exposure, and potentially even the health status of whole communities.EHP Freezers at the National Sewage Sludge Repository hold hundreds of samples of raw sewage and sludge collected from more than 200 sites around the United States.© Arjunkrishna Venkatesan   Most chemicals...
Source: EHP Research - May 2, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News May 2016 Source Type: research