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Specialty: Molecular Biology
Drug: Lithium
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Total 87 results found since Jan 2013.
Lithium prevents glucocorticoid ‑induced chondrocyte autophagy: An in vitro study
In conclusion, the present study demonstrated that lithium can prevent glucocorticoid‑induced autophagy by activating the PI3K/AKT/mTOR signaling pathway and preventing the glucocorticoid‑induced decrease in chondrocyte viability.PMID:37594059 | DOI:10.3892/mmr.2023.13070
Source: Molecular Medicine - August 18, 2023 Category: Molecular Biology Authors: Qiuru Wang Wanli Zhang Jian Hu Chengcheng Zhao Lijun Cai Pengde Kang Source Type: research
Outer Arm Dynein Light Chain LC1 Is Required for Normal Motor Assembly Kinetics, Ciliary Stability and Motility
Mol Biol Cell. 2023 May 3:mbcE23030104. doi: 10.1091/mbc.E23-03-0104. Online ahead of print.ABSTRACTLight chain 1 (LC1) is a highly conserved leucine-rich repeat protein associated with the microtubule-binding domain of the Chlamydomonas outer dynein arm γ heavy chain. LC1 mutations in humans and trypanosomes lead to motility defects while its loss in oomycetes results in aciliate zoospores. Here we describe a Chlamydomonas LC1 null mutant (dlu1-1). This strain has reduced swimming velocity and beat frequency, can undergo waveform conversion but often exhibits loss of hydrodynamic coupling between the cilia. Following dec...
Source: Mol Biol Cell - May 3, 2023 Category: Molecular Biology Authors: Miho Sakato-Antoku Stephen M King Source Type: research
Lithium-induced ciliary lengthening sparks Arp2/3 complex-dependent endocytosis
Mol Biol Cell. 2023 Feb 8:mbcE22060219. doi: 10.1091/mbc.E22-06-0219. Online ahead of print.ABSTRACTCiliary length is highly regulated, but can be disrupted by lithium, which causes ciliary elongation across cell types and organisms. We used the algal system Chlamydomonas reinhardtii to investigate the mechanism behind lithium-induced ciliary elongation. Protein synthesis is not required for lengthening and the target of lithium, GSK3, has substrates that can influence membrane dynamics. Further, ciliary assembly requires a supply of ciliary membrane as well protein. Lithium-treated cilia elongate normally with Brefeldin t...
Source: Mol Biol Cell - February 8, 2023 Category: Molecular Biology Authors: Brae M Bigge Larissa L Dougherty Prachee Avasthi Source Type: research
Effects of different doses of lithium on the central nervous system in the rat valproic acid model of autism
Chem Biol Interact. 2022 Dec 16:110314. doi: 10.1016/j.cbi.2022.110314. Online ahead of print.NO ABSTRACTPMID:36535311 | DOI:10.1016/j.cbi.2022.110314
Source: Chemico-Biological Interactions - December 19, 2022 Category: Molecular Biology Authors: Juling Wang Chenlu Xu Chenyang Liu Qinfeng Zhou Guanqun Chao Yongtang Jin Source Type: research
Evaluation of in vivo lithium chloride effects as a GSK3- β inhibitor on human adipose derived stem cells differentiation into oligodendrocytes and re-myelination in an animal model of multiple sclerosis
Mol Biol Rep. 2022 Dec 17. doi: 10.1007/s11033-022-08181-8. Online ahead of print.NO ABSTRACTPMID:36526850 | DOI:10.1007/s11033-022-08181-8
Source: Molecular Biology Reports - December 16, 2022 Category: Molecular Biology Authors: Sahar Ghosouri Mitra Soleimani Mohammad Bakhtiari Nazem Ghasemi Source Type: research
Exosomal STAT1 derived from high phosphorus ‑stimulated vascular endothelial cells induces vascular smooth muscle cell calcification via the Wnt/β‑catenin signaling pathway
In conclusion, the present results indicated that exosomal STAT1 derived from HP‑treated HUVECs could promote VSMC calcification, and activation of the Wnt/β‑catenin pathway may be a potential mechanism of the VSMC calcification promoted by exosomes.PMID:36281932 | DOI:10.3892/ijmm.2022.5195
Source: International Journal of Molecular Medicine - October 25, 2022 Category: Molecular Biology Authors: Zheng Qin Yupei Li Jiameng Li Luojia Jiang Zhuyun Zhang Kaixi Chang Qinbo Yang Shanshan Chen Ruoxi Liao Baihai Su Source Type: research
High-Efficiency Plasmid DNA Transformation in Yeast
Methods Mol Biol. 2022;2513:15-22. doi: 10.1007/978-1-0716-2399-2_2.ABSTRACTTransformation of DNA into cells of the budding yeast Saccharomyces cerevisiae and other industrially important yeasts is most commonly performed using chemical-based methods. Current protocols typically involve exposure of the cells to lithium ions in a solution containing the crowding agent polyethylene glycol (PEG), often in conjunction with other reagents such as dimethyl sulfoxide (DMSO) that promote destabilization of the cell wall and/or cell envelope. Recent work has demonstrated that it is possible to achieve high transformation efficienci...
Source: Mol Biol Cell - July 5, 2022 Category: Molecular Biology Authors: O'Taveon R Fitzgerald Nestor D Rodriguez L Kevin Lewis Source Type: research
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the hippocampus of lithium-pilocarpine-induced acute epileptic rats
CONCLUSIONS: The expression of MMPs and TIMPs reflects a novel feature of epileptogenesis and may offer new perspectives for future therapeutic interventions.PMID:35715602 | DOI:10.1007/s11033-022-07277-5
Source: Molecular Biology Reports - June 17, 2022 Category: Molecular Biology Authors: Ding Wan Lu Yang Jia Ren Haiyue Huang Chen Zhang Le Chen Xueyao Su Qi Huang Jianguo Niu Tao Sun Peng Wang Source Type: research
