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Total 37 results found since Jan 2013.

A Combination of Atorvastatin and Aspirin Enhances the Pro-Regenerative Interactions of Marrow Stromal Cells and Stroke-Derived Monocytes In Vitro
Conclusion: Atorvastatin, alone and in combination with aspirin can promote anti-inflammatory effect by modulating the secretome profile of Mo and MSCs. Our results suggest that stroke trials involving the use of intravenous MSCs should consider the effect of aspirin and atorvastatin, both of which are administered to the majority of hospitalized ischemic stroke patients.
Source: Frontiers in Pharmacology - April 20, 2021 Category: Drugs & Pharmacology Source Type: research

Lipophilic Statins and the Risk of Intracranial Hemorrhage Following Ischemic Stroke: A Population-Based Study
ConclusionAmong patients treated with a statin following ischemic stroke, the risk of intracranial hemorrhage is not influenced by statin lipophilicity.
Source: Drug Safety - June 15, 2017 Category: Drugs & Pharmacology Source Type: research

Effect of atorvastatin on expression of TLR4 and NF- κB in stroke rats and its protective effect on brain.
CONCLUSIONS: Atorvastatin can effectively reduce the expression of TLR4 and NF-κB in brain tissue of stroke rats, and has a certain protective effect on cerebral nerve function, which is expected to be the first choice for stroke treatment in the future. PMID: 33155240 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - November 10, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Rutin protects hemorrhagic stroke development via supressing oxidative stress and inflammatory events in a zebrafish model
Eur J Pharmacol. 2022 Apr 22:174973. doi: 10.1016/j.ejphar.2022.174973. Online ahead of print.ABSTRACTIntracerebral haemorrhagic (ICH) stroke is a major cause of death and disability globally, with no proper treatment available so far. Rutin, a dietary flavonoid, has shown protection against cerebral ischemic stroke due to its antioxidant and anti-inflammatory attributes. However, the efficacy of rutin against ICH stroke remained unexplored. Therefore, in the current study, we investigated the effect of rutin in an ICH stroke zebrafish larva model. The larvae were exposed to atorvastatin (1.25 μM) in system water for indu...
Source: European Journal of Pharmacology - April 26, 2022 Category: Drugs & Pharmacology Authors: Anil Kumar Rana Supriya Sharma Shiv Kumar Saini Damanpreet Singh Source Type: research

PPARα is involved in the multi‐targeted effects of a pre‐treatment with atorvastatin in experimental stroke
This article is protected by copyright. All rights reserved.
Source: Fundamental and Clinical Pharmacology - April 1, 2013 Category: Drugs & Pharmacology Authors: Thavarak Ouk, Camille Potey, Maud Laprais, Sophie Gautier, Rémi Hanf, Raphaël Darteil, Bart Staels, Patrick Duriez, Régis Bordet Tags: Original Article Source Type: research

PPARα is involved in the multitargeted effects of a pretreatment with atorvastatin in experimental stroke
Abstract There is now substantial data in the literature showing that statins can protect against cerebral ischemia. This neuroprotective potency is related to their pleiotropic effects that modulate various pathways implicated in the pathophysiology of stroke. It has been demonstrated that statins exert anti‐inflammatory and vasculoprotective effects, thus contributing to a reduction in infarct size. The underlying mechanisms are still incompletely known. As a cross‐talk between statins and the nuclear receptor PPARα has been described, we hypothesized that this cross‐talk is necessary to neuroprotection in stroke....
Source: Fundamental and Clinical Pharmacology - May 23, 2013 Category: Drugs & Pharmacology Authors: Thavarak Ouk, Camille Potey, Maud Laprais, Sophie Gautier, Rémi Hanf, Raphaël Darteil, Bart Staels, Patrick Duriez, Régis Bordet Tags: Original Article Source Type: research

Effects of long-term regular oral aspirin combined with atorvastatin to prevent ischemic stroke on human gut microbiota
CONCLUSIONS: Our findings indicated that long-term regular oral aspirin and atorvastatin modulate the human gut microbiota. Taking these drugs may affect the preventive effect of ischemic stroke by changing the abundance of specific gut microbiota.PMID:37201625 | DOI:10.1016/j.ejphar.2023.175800
Source: European Journal of Pharmacology - May 18, 2023 Category: Drugs & Pharmacology Authors: Guangtang Chen Zili Wang Wenxue Song Yidong Liao Xudong Wang Chen Chen Jiang Ming Junshuan Cui Kaya Xu Source Type: research

Polymorphisms in CYP450 Genes and the Therapeutic Effect of Atorvastatin on Ischemic Stroke: A Retrospective Cohort Study in Chinese Population.
Abstract PURPOSE: Ischemic stroke (IS) is one of the most common neurologic diseases and is the main cause of death and disability in the Chinese population. This retrospective cohort study was performed to elucidate the relationship between single nucleotide polymorphisms (SNPs) in cytochrome P450 genes and the therapeutic effect of atorvastatin. METHODS: A total of 192 cases of IS were enrolled in the study. All patients were treated with atorvastatin, and their lipid levels and proportions were measured. Six SNPs in 4 cytochrome P450 genes (CYP2C19, CYP2D6, CYP3A4, and CYP4F2) related to drug metabolism we...
Source: Clinical Therapeutics - February 27, 2018 Category: Drugs & Pharmacology Authors: Peng C, Ding Y, Yi X, Shen Y, Dong Z, Cao L, Li Q, Ren H, He L, Zhou D, Chen X Tags: Clin Ther Source Type: research

A meta-analysis of pharmacological neuroprotection in noncardiac surgery: focus on statins, lidocaine, ketamine, and magnesium sulfate.
CONCLUSIONS: The available clinical data are still scarce. Our analyses indicate no protective effects by statins against perioperative stroke but some favorable trends toward delayed stroke. Further randomized trials are needed to unequivocally assess the neuroprotective potential of current pharmacological agents in non-cardiac surgery. PMID: 29630129 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 10, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Early treatment with atorvastatin exerts parenchymal and vascular protective effects in experimental cerebral ischemia
CONCLUSIONS AND IMPLICATIONSAcute atorvastatin provides global cerebral protection, but only at the higher dose of 20 mg/kg/d, related to a reduction of inflammation in both vascular and parenchymal compartments. Our results suggest that atorvastatin could also be beneficial when administered early after stroke.
Source: British Journal of Pharmacology - August 19, 2015 Category: Drugs & Pharmacology Authors: C Potey, T Ouk, O Petrault, M Petrault, V Berezowski, J Salleron, R Bordet, S Gautier Tags: RESEARCH PAPER Source Type: research

Atorvastatin Modulates Regulatory T Cells and Attenuates Cerebral Damage in a Model of Transient Middle Cerebral Artery Occlusion in Rats
AbstractRegulatory T cells (Tregs) inhibit the activation of the immune response which could down-regulate the systemic and focal activation observed during ischemic stroke. In fact, in animal models, Tregs infiltrate the infarcted brain and reduce the pro-inflammatory cytokine production and infarct volume, mainly in late stages of ischemia. Recently, an expansion and greater suppressive capacity of circulating Tregs after treatment with statins was observed, in addition to their cardio- and neuroprotective actions demonstrated previously. Thus, to determine whether Treg modulation mediated by statins can also be benefici...
Source: Journal of NeuroImmune Pharmacology - September 9, 2016 Category: Drugs & Pharmacology Source Type: research

Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting VE-cadherin internalization and actin-myosin contractility
Publication date: Available online 7 October 2017 Source:Pharmacological Research Author(s): Bin Huang, Zhong-Yan Zhou, Shang Li, Xiao-Hui Huang, Jing-Yi Tang, Maggie Pui Man Hoi, Simon Ming Yuen Lee Defects in vascular integrity in cerebrovasculature lead to serious pathologies including hemorrhagic stroke. The stability of cell adhesion junctions and actin-myosin contractile machinery are two major determinants for the integrity of endothelial monolayer. Here we have evaluated the protective effects of tanshinone I (Tan I), a lipophilic compound presents in Salvia miltiorrhiza, against atorvastatin-induced cerebral hemo...
Source: Pharmacological Research - October 8, 2017 Category: Drugs & Pharmacology Source Type: research