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Drug: Insulin
Nutrition: Antidoxidants
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Total 1451 results found since Jan 2013.
Effects of < em > Aeriscardovia aeriphila < /em > on growth performance, antioxidant functions, immune responses, and gut microbiota in broiler chickens
In conclusion, oral administration of A. aeriphila could improve the growth performance, serum antioxidant capacity, immune modulation, and gut health of broilers. Our findings may provide important information for the application of A. aeriphila in poultry production.PMID:37735944 | DOI:10.1631/jzus.B2200621
Source: J Zhejiang Univ Sci ... - September 22, 2023 Category: Science Authors: Muhammad Zahid Farooq Xinkai Wang Xianghua Yan Source Type: research
D-pinitol ameliorated H < sub > 2 < /sub > O < sub > 2 < /sub > -induced oxidative damage in PC12 cells and prolonged the lifespan by IIS pathway in Caenorhabditis elegans
In this study, we intended to explore the anti-aging mechanism of DP, utilizing computer modeling techniques. The results demonstrated that DP significantly delayed H2O2-induced cellular senescence. Model PC12 cells treated with DP exhibited increased cell viability, increased antioxidant enzyme activity (SOD, CAT), and reduced ROS and MDA levels. Furthermore, DP was discovered to have a positive effect on healthy longevity. In C. elegans, DP treatment enhanced lifespan, stress capacity, antioxidant capacity (T-SOD/CAT/GSH-Px/MDA/ROS), and altered aging-related indicators of lipofuscin accumulation, pharyngeal pump rate, m...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 21, 2023 Category: Biochemistry Authors: Miaosi Zhang Zhe Xu Liangyong Shao Jilite Wang Zouyan He Yumei Jiang Ye Zhang Hao Wang Source Type: research
Thymoquinone attenuates olanzapine-induced metabolic disorders in rats
CONCLUSIONS: The present study demonstrates the effectiveness of TQ on OLZ-induced metabolic abnormalities related to its antioxidant activity and regulation of glucose homeostasis and lipid metabolism.PMID:37707771 | DOI:10.1007/s11033-023-08726-5
Source: Molecular Biology Reports - September 14, 2023 Category: Molecular Biology Authors: Farima Kaviani Bibi Marjan Razavi Mahdieh Sadat Mohsenzadeh Maryam Rameshrad Hossein Hosseinzadeh Source Type: research
Nrf2: Therapeutic target of islet function protection in diabetes and islet transplantation
Biomed Pharmacother. 2023 Sep 11;167:115463. doi: 10.1016/j.biopha.2023.115463. Online ahead of print.ABSTRACTNuclear factor-erythroid 2-related factor 2 (Nrf2) has been reported as a major intracellular regulator of antioxidant stress, notably in islet β cells with low antioxidant enzyme content. Nrf2 is capable of regulating antioxidant function, while it can also regulate insulin secretion, proliferation, and differentiation of β cells, ER stress, as well as mitochondrial function. Thus, Nrf2 pharmacological activators have been employed in the laboratory for the treatment of diabetic mice. Islet cells are exposed to ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 13, 2023 Category: Drugs & Pharmacology Authors: Butian Wei Xin Zhang Jiwei Qian Zhe Tang Bo Zhang Source Type: research
Hypolipidemic effect of β-caryophyllene in high fat diet and fructose induced type-2 diabetic adult male rats
Bioinformation. 2022 Nov 30;18(11):1087-1091. doi: 10.6026/973206300181087. eCollection 2022.ABSTRACTSkeletal muscle is responsible for the majority of insulin-stimulated whole-body glucose elimination, under normal circumstances. High dietary fat consumption increases stored fat mass and is a major risk factor for metabolic disorders. The conventional pharmacological treatments are associated with many adverse side effects and high rates of secondary failure which lead to an increasing demand for natural products with anti-diabetic activity and lesser side effects. β-Caryophyllene is a naturally occurring sequiterpene th...
Source: Bioinformation - September 11, 2023 Category: Bioinformatics Authors: Vadivel Mani Manikandan Balraj Nithya Rajapandian Chaitra Jinka Shyamaladevi Babu Source Type: research
Intense caloric restriction from birth prevents cardiovascular aging in rats
In this study, we investigated in middle-aged rats the consequences of a 50% caloric restriction (CR) from birth on cardiometabolic risk factors, heart function/morphology, ventricular arrhythmia, and fibrillation incidence, and cardiac intracellular proteins involved with redox status and cell survival. From birth to the age of 18 months, rats were divided into an Ad Libitum group (AL18), which had free access to food, and a CR18 group, which had food limited to 50% of that consumed by the AL18. Resting metabolic rate, blood pressure, and heart rate were recorded, and oral glucose and intraperitoneal insulin tolerance tes...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Dirceu de Sousa Melo Liliane Costa-Pereira Carina Sousa Santos Bruno Ferreira Mendes Isaac Konig Bruna Chaves Garcia Ilkilene Queiroz Lauane Gomes Moreno Ricardo Cardoso Cassilhas Elizabethe Adriana Esteves Etel Vieira Rocha Fl ávio Castro Magalhães Luc Source Type: research
The Antioxidant and anti-inflammatory Activity of Selenium and Lecithin Combination Against ethanol-induced Gastric Ulcer in mice via Modulating IGF-1/PTEN/Akt/FoxO3a Signaling
Biol Trace Elem Res. 2023 Sep 7. doi: 10.1007/s12011-023-03831-9. Online ahead of print.ABSTRACTGastric ulcers are one of the most prevalent gastrointestinal disorders. The current study investigated the antioxidant and anti-inflammatory effects of selenium (Se) and lecithin (Lec) alone and in combination against ethanol-induced gastric ulcers in mice, and their ability to modulate insulin-like growth factor-1 (IGF-1)/ Phosphatase and tensin homologue deleted on chromosome 10 (PTEN)/ Protein kinase B (Akt)/ Forkhead box O3a (FoxO3a) signaling. The mice were divided into normal, ethanol, Se + ethanol, Lec + ethanol, Se + Le...
Source: Biological Trace Element Research - September 7, 2023 Category: Biology Authors: Ahmed M M Youssef Hussein H N Abu-Ghazaleh Rawan Al-Suhaimat Rasha M Hussein Source Type: research
Isosteviol attenuates streptozotocin-mediated diabetic nephropathy in rats by upregulating and stimulating adenosine monophosphate-activated protein kinase
In conclusion, AMPK-induced inhibition of NF-κB and activation of Nrf2 entails the nephroprotective effect of ISV in STZ-diabetic rats.PMID:37661183 | DOI:10.26402/jpp.2023.3.06
Source: J Physiol Pharmacol - September 3, 2023 Category: Drugs & Pharmacology Authors: J Z Altamimi N A Alfaris G M Alshammari R I Alagal D H Aljabryn M A Yahya Source Type: research
