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Phytotherapy as Multi-Hit Therapy to Confront the Multiple Pathophysiology in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Experimental Interventions
Conclusions: These findings suggest that herbal extracts have the potential for effective treatment or management of NAFLD.PMID:34441028 | PMC:PMC8400978 | DOI:10.3390/medicina57080822
Source: Medicina (Kaunas) - August 27, 2021 Category: Universities & Medical Training Authors: Ayokanmi Ore Oluseyi Adeboye Akinloye Source Type: research
A Comprehensive Review of Neuronal Changes in Diabetics
Cureus. 2021 Oct 30;13(10):e19142. doi: 10.7759/cureus.19142. eCollection 2021 Oct.ABSTRACTThere has been an exponential rise in diabetes mellitus (DM) cases on a global scale. Diabetes affects almost every system of the body, and the nervous system is no exception. Although the brain is dependent on glucose, providing it with the energy required for optimal functionality, glucose also plays a key role in the regulation of oxidative stress, cell death, among others, which furthermore contribute to the pathophysiology of neurological disorders. The variety of biochemical processes engaged in this process is only matched by ...
Source: Cancer Control - December 6, 2021 Category: Cancer & Oncology Authors: Rudy Luna Ramya Talanki Manjunatha Bhaswanth Bollu Sharan Jhaveri Chaithanya Avanthika Nikhil Reddy Tias Saha Fenil Gandhi Source Type: research
The Theory of Hyperlipidemic Memory of Type 1 Diabetes
Front Endocrinol (Lausanne). 2022 Mar 31;13:819544. doi: 10.3389/fendo.2022.819544. eCollection 2022.ABSTRACTA literature search was conducted to identify publications addressing the early phases of lipid phenotypes in children and adults with either type 1 diabetes or type 2 diabetes. Medline, EMBASE, and Ovid were searched using the following search terms: clinical remission, partial remission, partial clinical remission, honeymoon phase, C-peptide, type 1 or 2 diabetes, children, pediatric type 1 or 2 diabetes, and paediatrics type 1 or 2 diabetes, adults, adult type 1 or type 2 diabetes. Partial clinical remission (PR)...
Source: Atherosclerosis - April 18, 2022 Category: Cardiology Authors: Benjamin Udoka Nwosu Source Type: research
New insights on the cardiovascular effects of IGF-1
DISCUSSION: We anticipate the development of novel IGF-1-related therapy with minimal side effects. This review discusses recent findings on the role of IGF-1 in the cardiovascular (CVD) system, including both normal and pathological conditions. We also discuss progress in therapeutic interventions aimed at targeting the IGF axis and provide insights into the epigenetic regulation of IGF-1 mediated by microRNAs.PMID:36843588 | PMC:PMC9947133 | DOI:10.3389/fendo.2023.1142644
Source: Atherosclerosis - February 27, 2023 Category: Cardiology Authors: Mirjana Macvanin Zoran Gluvic Jelena Radovanovic Magbubah Essack Xin Gao Esma R Isenovic Source Type: research
A systematic review and meta-analysis for the association of the insulin-like growth factor1 pathway genetic polymorphisms with colorectal cancer susceptibility
CONCLUSIONS: This systematic review and meta-analysis provide evidence that genetic variants in IGF1 rs6214C>T, IRS1 rs1801278G>A, and IRS2 rs1805097G>A are associated with an increased risk of CRC. These findings may contribute to a better understanding of the complex genetic mechanisms involved in CRC development and could inform future research on prevention and treatment strategies for this disease.PMID:37284192 | PMC:PMC10240407 | DOI:10.3389/fonc.2023.1168942
Source: Cancer Control - June 7, 2023 Category: Cancer & Oncology Authors: Makan Cheraghpour Masomeh Askari Sascha Tierling Sajad Shojaee Amir Sadeghi Pardis Ketabi Moghadam Maryam Khazdouz Hamid Asadzadeh Aghdaei Moein Piroozkhah Ehsan Nazemalhosseini-Mojarad Nayeralsadat Fatemi Source Type: research
Detection Study of Bipolar Depression Through the Application of a Model-Based Algorithm in Terms of Clinical Feature and Peripheral Biomarkers
Conclusion: It seems to be feasible to combine different types of clinical characteristics with biomarkers in order to detect bipolarity of all depressive episodes. Neurotrophic factors of our interest presented its stable discriminant potentiality in unipolar and bipolar depression, deserving validation analysis in larger samples.IntroductionThe Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) separates the mood disorders into two sections: depressive and related disorders, and bipolar and related disorders. The new version of the diagnostic manual of bipolar disorders emphasizes more specific ...
Source: Frontiers in Psychiatry - April 30, 2019 Category: Psychiatry Source Type: research
Correlates of serum IGF-1 in young children with moderate acute malnutrition: a cross-sectional study in Burkina Faso
CONCLUSIONS: LAZ and WLZ were positively and inflammation negatively associated with sIGF-1. As all children were moderately malnourished and many had inflammation, this probably explains the very low median sIGF-1. The association of FFM with sIGF-1 was fully explained by height. There was a marked age pattern, with a nadir in late infancy, confirming findings from smaller studies from well-nourished populations. There is a need for prospective studies to disentangle the role of sIGF-1 in growth and health. This trial was registered at https://www.isrctn.com as ISRCTN42569496.PMID:33963730 | DOI:10.1093/ajcn/nqab120
Source: The American Journal of Clinical Nutrition - May 8, 2021 Category: Nutrition Authors: Thora W Kjaer Benedikte Grenov Charles W Yam éogo Christian Fabiansen Ann-Sophie Iuel-Brockdorff Bernardette Cichon Nick S Nielsen Suzanne Filteau Andr é Briend Jonathan C K Wells Kim F Michaelsen Henrik Friis Daniel Faurholt-Jepsen Vibeke B Christensen Source Type: research
