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Specialty: Cardiology
Drug: Insulin

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Total 191 results found since Jan 2013.

Metabolic syndrome in the prediction of cardiovascular events: the potential additive role of hsCRP and adiponectin
Conclusions MS is an important predictor of cardiovascular events and is most harmful in combination with high plasma hsCRP. The clustering of components is especially harmful.
Source: European Journal of Preventive Cardiology - September 16, 2014 Category: Cardiology Authors: Santaniemi, M., Ukkola, O., Malo, E., Bloigu, R., Kesaniemi, Y. A. Tags: Original scientific papers Source Type: research

Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists
Patients with type 2 diabetes have a several-fold increased risk of developing cardiovascular disease when compared with nondiabetic controls. Myocardial infarction and stroke are responsible for 75% of all death in patients with diabetes, who present a 2-4x increased incidence of death from coronary artery disease. Patients with diabetes are considered for cardiovascular disease secondary prevention because their risk level is similar to that reported in patients without diabetes who have already suffered a myocardial infarction. More recently, with a better risk factors control, mainly in intensive LDL cholesterol target...
Source: Cardiovascular Diabetology - October 22, 2014 Category: Cardiology Authors: Francisco SaraivaAndrei Sposito Source Type: research

Asymmetric dimethylarginine and long-term adverse cardiovascular events in patients with type 2 diabetes: relation with the glycemic control
Conclusions: In patients with type 2 diabetes, ADMA might be an independent risk factor for long-term adverse cardiovascular events. However, ADMA was not correlated with serum HbA1c level, and in diabetic patients with HbA1c ?6.5%, elevated ADMA level was no longer associated with increased risk of long-term prognosis. Our findings suggested that the prognosis predictive value of ADMA in type 2 diabetes might be modified by the glycemic control.
Source: Cardiovascular Diabetology - December 3, 2014 Category: Cardiology Authors: Chiao-Po HsuPai-Feng HsuMing-Yi ChungShing-Jong LinTse-Min Lu Source Type: research

Age-Specific Performance of the Revised Cardiac Risk Index for Predicting Cardiovascular Risk in Elective Noncardiac Surgery Original Articles
Conclusions— In a nationwide unselected cohort, the performance of the RCRI was similar to that of the original cohort. Having ≥1 risk factor was of moderate sensitivity, but high negative predictive value for all ages.
Source: Circulation: Cardiovascular Quality and Outcomes - January 20, 2015 Category: Cardiology Authors: Andersson, C., Wissenberg, M., Jorgensen, M. E., Hlatky, M. A., Merie, C., Jensen, P. F., Gislason, G. H., Kober, L., Torp-Pedersen, C. Tags: Other diagnostic testing Original Articles Source Type: research

Adiponectin, type 2 diabetes and cardiovascular risk
Conclusions In conclusion, increasing plasma adiponectin is associated with decreased risk of T2DM and subsequently reduced risk of CV events.
Source: European Journal of Preventive Cardiology - February 10, 2015 Category: Cardiology Authors: Lindberg, S., Jensen, J. S., Bjerre, M., Pedersen, S. H., Frystyk, J., Flyvbjerg, A., Galatius, S., Jeppesen, J., Mogelvang, R. Tags: Original scientific paper Source Type: research

Protective effects of methotrexate against ischemic cardiovascular disorders in patients treated for rheumatoid arthritis or psoriasis: novel therapeutic insights coming from a meta-analysis of the literature data.
CONCLUSION: Methotrexate at low doses, such those used for maintenance therapy of RA, predicted a decreased risk of CVE. Since methotrexate doesn't interfere with blood lipids, platelet aggregation or insulin resistance, the protective association may originate from mechanisms other than those exerted by antiplatelet drugs or statins. PMID: 25697810 [PubMed - as supplied by publisher]
Source: The Anatolian Journal of Cardiology - February 16, 2015 Category: Cardiology Authors: De Vecchis R, Baldi C, Palmisani L Tags: Anadolu Kardiyol Derg Source Type: research

Is the Long-Term Outcome of PCI or CABG in Insulin-Treated Diabetic Patients Really Worse Than Non-Insulin-Treated Ones?
In a recent issue of the Journal, Dangas et al. (1), after analyzing 1,850 subjects from the FREEDOM (Comparison of Two Treatments for Multivessel Coronary Artery Disease in Individuals With Diabetes) trial, found that in patients with diabetes and multivessel coronary artery disease, the rate of major adverse cardiovascular events (death, myocardial infarction, or stroke) is higher in patients treated with insulin than it is in those not treated with insulin. Their work is excellent, and the results deserved to be considered given the large number of patients with diabetes and multivessel coronary artery disease who are...
Source: Journal of the American College of Cardiology - March 16, 2015 Category: Cardiology Source Type: research

Insulin Resistance and Risk of Cardiovascular Disease in Postmenopausal Women: A Cohort Study From the Women's Health Initiative Original Articles
Conclusions— Measures of insulin resistance were no longer associated with CVD risk after adjustment for high-density lipoprotein-cholesterol and did not provide independent prognostic information in postmenopausal women without diabetes mellitus. Clinical Trial Registration Information— URL: http://www.clinicaltrial.gov. Unique identifier: NCT00000611.
Source: Circulation: Cardiovascular Quality and Outcomes - May 19, 2015 Category: Cardiology Authors: Schmiegelow, M. D., Hedlin, H., Stefanick, M. L., Mackey, R. H., Allison, M., Martin, L. W., Robinson, J. G., Hlatky, M. A. Tags: Health policy and outcome research, Risk Factors, Acute myocardial infarction, Acute Cerebral Infarction, Epidemiology Original Articles Source Type: research

High Event Rate After a First Percutaneous Coronary Intervention in Patients With Diabetes Mellitus: Results From the Swedish Coronary Angiography and Angioplasty Registry Coronary Interventions
Conclusions— The prognosis after a first percutaneous coronary intervention is more severe in patients with diabetes mellitus, in particular, in patients treated with insulin, with higher rates of mortality, cardiovascular events, and stent thrombosis over the following 5 years.
Source: Circulation: Cardiovascular Interventions - May 29, 2015 Category: Cardiology Authors: Ritsinger, V., Saleh, N., Lagerqvist, B., Norhammar, A. Tags: Type 2 diabetes, Catheter-based coronary interventions: stents Source Type: research

Comparison of outcomes after everolimus-eluting stent implantation in diabetic versus non-diabetic patients in the Tokyo-MD PCI study.
CONCLUSIONS: In this all-comer, observational study, the risk of TLR was greater in IRDM compared with non-DM after EES implantation, while the increased risk for TLR from NIRDM did not reach statistical significance. PMID: 26130583 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - June 27, 2015 Category: Cardiology Authors: Konishi Y, Ashikaga T, Sasaoka T, Kurihara K, Yoshikawa S, Isobe M Tags: J Cardiol Source Type: research

Heartbeat: Highlights from this issue
Prevention of atrial fibrillation (AF) is an urgent unmet clinical need given its association with a higher risk of stroke, heart failure and death. Known risk factors for AF include age, hypertension, body mass index and diabetes as well as markers of systemic inflammation; all of which likely contribute to the high prevalence of this dysrhythmia in our aging, increasingly obese, population. However, there currently are no established biomarkers to help in assessment of AF risk. Adiponectin is an adipocyte-generated hormone with lower levels seen with increased adiposity. Adiponectin has insulin sensitizing, anti-inflamma...
Source: Heart - August 12, 2015 Category: Cardiology Authors: Otto, C. M. Tags: Drugs: cardiovascular system, Hypertension, Epidemiology, Tobacco use Heartbeat Source Type: research

Lifestyle Choices Fuel Epidemics of Diabetes and Cardiovascular Disease among Asian Indians
Within the next 15 years, India is projected to overtake China as the world’s most populous nation. Due to the rapid pace of urbanization and modernization fueling population growth, in conjunction with a genetic predisposition to insulin resistance, India is suffering a rising epidemic of non-communicable diseases (NCDs), including coronary artery disease (CAD), type 2 diabetes mellitus (T2DM), and stroke. In addition to the genetic predisposition, major negative lifestyle factors are contributing to the alarming outbreak of cardiovascular disease (CVD) among the Asian Indian population; these factors include:1) a diet ...
Source: Progress in Cardiovascular Diseases - August 12, 2015 Category: Cardiology Authors: Evan L. O’Keefe, James J. DiNicolantonio, Harshal Patil, John H. Helzberg, Carl J. Lavie Source Type: research

Plasma Levels of Soluble IL-2 Receptor α: Associations With Clinical Cardiovascular Events and Genome-Wide Association Scan.
CONCLUSIONS: These results support a role for sIL-2Rα in atherosclerosis and provide evidence for multiple-associated single-nucleotide polymorphisms at chromosome 10p15-14. PMID: 26293465 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 20, 2015 Category: Cardiology Authors: Durda P, Sabourin J, Lange EM, Nalls MA, Mychaleckyj JC, Jenny NS, Li J, Walston J, Harris TB, Psaty BM, Valdar W, Liu Y, Cushman M, Reiner AP, Tracy RP, Lange LA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Adipose tissue-derived stem cells as a therapeutic tool for cardiovascular disease.
Abstract Adipose tissue-derived stem cells (ADSCs) are adult stem cells that can be easily harvested from subcutaneous adipose tissue. Many studies have demonstrated that ADSCs differentiate into vascular endothelial cells (VECs), vascular smooth muscle cells (VSMCs), and cardiomyocytes in vitro and in vivo. However, ADSCs may fuse with tissue-resident cells and obtain the corresponding characteristics of those cells. If fusion occurs, ADSCs may express markers of VECs, VSMCs, and cardiomyocytes without direct differentiation into these cell types. ADSCs also produce a variety of paracrine factors such as vascular...
Source: World Journal of Cardiology - August 26, 2015 Category: Cardiology Authors: Suzuki E, Fujita D, Takahashi M, Oba S, Nishimatsu H Tags: World J Cardiol Source Type: research

Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes
Type 2 diabetes mellitus (T2DM) is characterized by multiple pathophysiologic abnormalities. With time, multiple glucose-lowering medications are commonly required to reduce and maintain plasma glucose concentrations within the normal range. Type 2 diabetes mellitus individuals also are at a very high risk for microvascular complications and the incidence of heart attack and stroke is increased two- to three-fold compared with non-diabetic individuals. Therefore, when selecting medications to normalize glucose levels in T2DM patients, it is important that the agent not aggravate, and ideally even improve, cardiovascular ri...
Source: European Heart Journal - September 7, 2015 Category: Cardiology Authors: Ferrannini, E., DeFronzo, R. A. Tags: Clinical update Source Type: research