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Total 69 results found since Jan 2013.

Outcomes of systemic bevacizumab in radiation-induced optic neuropathy, case series
ConclusionSystemic bevacizumab may stabilize vision in some patients with RION, though the limitations of our study do not allow us to draw this conclusion definitively. Therefore, the risks and potential benefits of using IV bevacizumab should be considered in each individual case.
Source: Journal of Neuro-Oncology - May 25, 2023 Category: Cancer & Oncology Source Type: research

Hereditary hemorrhagic telangiectasia
Rev Mal Respir. 2023 Apr 14:S0761-8425(23)00136-5. doi: 10.1016/j.rmr.2023.02.007. Online ahead of print.ABSTRACTHereditary hemorrhagic telangiectasia, also known as Rendu-Osler - Weber disease, is a rare, autosomal dominant vascular disease, with prevalence of 1/5,000. The condition is characterized by muco-cutaneous telangiectasias, which are responsible for a hemorrhagic syndrome of variable severity, as well as arteriovenous malformations (AVMs) appearing in the lungs, the liver, and the nervous system. They can be the source of shunts, which may be associated with high morbidity (neurological ischemic stroke, brain ab...
Source: Revue des Maladies Respiratoires - April 16, 2023 Category: Respiratory Medicine Authors: A Parrot M Barral X Amiot C Bachmeyer I Wagner M Eyries S Alamowitch S Ederhy R Epaud S Dupuis-Girod J Cadranel Source Type: research

VEGF regulates the blood ‑brain barrier through MMP‑9 in a rat model of traumatic brain injury
In conclusion, the present study revealed a potential role for TBI-associated VEGF and MMP-9 upregulation in BBB disruption and nerve damage post-TBI.PMID:36382093 | PMC:PMC9634340 | DOI:10.3892/etm.2022.11664
Source: Experimental and Therapeutic Medicine - November 16, 2022 Category: General Medicine Authors: Muyao Wu Yating Gong Lei Jiang Min Zhang Haiping Gu Hui Shen Baoqi Dang Source Type: research

Ischemic stroke in a patient with EGFR ‐mutated non–small‐cell lung cancer after treatment with ramucirumab
This article presents the case of a non–small-cell lun g cancer patient who experienced a new ischemic stroke after treatment with ramucirumab. The findings suggest that further studies may be necessary to investigate the relationship between ramucirumab and the risk of ischemic stroke.
Source: Thoracic Cancer - October 29, 2022 Category: Cancer & Oncology Authors: Guo ‐Yu Chen, Wen‐Chien Cheng, Chih‐Yen Tu Tags: CASE REPORT Source Type: research

Short bevacizumab infusion as an effective and safe treatment for colorectal cancer
Mol Clin Oncol. 2022 Jul 27;17(3):139. doi: 10.3892/mco.2022.2572. eCollection 2022 Sep.ABSTRACTBevacizumab is a humanized monoclonal antibody that contains <10% murine protein. To prevent infusion-related hypersensitivity reactions (HSRs), the initial bevacizumab infusion is delivered for 90 min, the second for 60 min and subsequent doses for 30 min. Several previous studies have shown that short bevacizumab infusions are safe and do not result in severe HSRs in patients with colorectal, lung, ovarian and brain cancer. However, the efficacy of short bevacizumab infusions for colorectal cancer management remains unclear...
Source: Clinical Colorectal Cancer - August 11, 2022 Category: Cancer & Oncology Authors: Koichi Taira Shunsuke Okazaki Kohei Akiyoshi Hirohisa Machida Tetsuro Ikeya Akie Kimura Akinobu Nakata Yuji Nadatani Masaki Ohminami Shusei Fukunaga Koji Otani Shuhei Hosomi Fumio Tanaka Noriko Kamata Yasuaki Nagami Yasuhiro Fujiwara Source Type: research

Pyruvate kinase M2 (PKM2) improve symptoms of post ‐ischemic stroke depression by activating VEGF to mediate the MAPK/ERK pathway
ConclusionPKM2 improves symptoms of post-ischemic stroke depression by activating VEGF-mediated MAPK/ERK pathway.
Source: Brain and Behavior - December 13, 2021 Category: Neurology Authors: Yun Feng, Xuebin Li, Jie Wang, Xiaohua Huang, Lanqing Meng, Jianmin Huang Tags: ORIGINAL ARTICLE Source Type: research