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Drug: Sodium Fluoride

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Total 24 results found since Jan 2013.

Thoracic Aortic < sup > 18 < /sup > F-Sodium Fluoride Activity and Ischemic Stroke in Patients With Established Cardiovascular Disease
CONCLUSIONS: In patients with established cardiovascular disease, thoracic aortic 18F-sodium fluoride activity is associated with the progression of atherosclerosis and future ischemic stroke. Arterial 18F-sodium fluoride activity identifies localized areas of atherosclerotic disease activity that are directly linked to disease progression and downstream regional clinical atherothrombotic events. (DIAMOND - Dual Antiplatelet Therapy to Reduce Myocardial Injury [DIAMOND], NCT02110303; Study Investigating the Effect of Drugs Used to Treat Osteoporosis on the Progression of Calcific Aortic Stenosis [SALTIRE II], NCT02132026; ...
Source: Atherosclerosis - February 20, 2022 Category: Cardiology Authors: Alexander J Fletcher Yong Y Tew Evangelos Tzolos Shruti S Joshi Jakub Kaczynski Jennifer Nash Samuel Debono Maria Lembo Jacek Kwiecinski Rong Bing Maaz B J Syed Mhairi K Doris Edwin J R van Beek Alistair J Moss William S Jenkins Niki L Walker Nikhil V Jos Source Type: research

Identification of Suspected Ruptured Atherosclerotic Plaque in Acute Ischemic Stroke on (18)F-Sodium Fluoride Positron Emission Tomography-Computed Tomography.
PMID: 25993996 [PubMed - as supplied by publisher]
Source: Circulation Journal - May 21, 2015 Category: Cardiology Authors: Hung GU, Hung CH, Chen TY, Kung WM, Wei CY, Kao CH, Uchiyama S Tags: Circ J Source Type: research

Cheap and easy 'toothpaste' test that spots risk of stroke and heart attack
Scientists claim the technique, which users sodium fluoride tagged with radioactive tracer, will transform the way doctors are able to identify patients at risk of a heart attack or stroke.
Source: the Mail online | Health - July 13, 2015 Category: Consumer Health News Source Type: news

Scan could detect those on brink of heart attack
Conclusion This is a valuable study which shows the promise of using PET-CT with radioactively labelled sodium fluoride (NaF) as a way of identifying fatty deposits in the heart arteries that could be at risk of rupturing and causing a heart attack. The results confirmed that the marker used in this study (NaF) was better than the chemical marker normally used in PET-CT scans (FDG). The technique has the principal value of being a non-invasive technique compared with coronary angiography, which is the standard method used to look at blockages in heart arteries. As it does not involve surgical intervention, this could ha...
Source: NHS News Feed - November 11, 2013 Category: Consumer Health News Tags: Heart/lungs Medical practice Source Type: news

The uptake pattern of 18F-sodium fluoride radioligand in brain tissue after cerebral infarction
In this study, we measured the maximum and mean standardized uptake value (SUVmax and SUVmean) of NaF uptake level in the cerebral infarct region between lesions with and without diffusion weighted image (DWI) positivity, indicating acute ischemic cell death. Correlation analysis was performed between NaF uptake levels and imaging and clinical variables, including neurological severity. The NaF uptake levels were significantly higher in DWI positive lesions than in negative lesions (SUVmax: 2.0 [0.60-4.2] versus 0.20 [0.10-0.40], p = 0.021 by Mann-Whitney U test). The intensity of NaF uptake (SUVmax) was significantly corr...
Source: Atherosclerosis - December 29, 2022 Category: Cardiology Authors: Jeong-Min Kim Reeree Lee Hae-Bong Jeong Kwang-Yeol Park Ju Won Seok Source Type: research

Exploring the nature of atheroma and cardiovascular inflammation in-vivo using Positron emission Tomography (PET).
Abstract Positron Emission Tomography (PET) has become widely established in oncology. Subsequently a whole new "toolbox" of tracers have become available to look at different aspects of cancer cell function and dysfunction including cell protein production, DNA synthesis, hypoxia and angiogenesis. In the last 5 years these tools have been used increasingly to look at the other great killer of the developed world; cardiovascular disease. For example inflammation of the unstable plaque can be imaged with fluorine-18 (F-18) fluorodeoxyglucose (FDG) and this uptake can be quantified to show the effect statins have in...
Source: The British Journal of Radiology - June 2, 2015 Category: Radiology Authors: Buscombe JR Tags: Br J Radiol Source Type: research

Symptomatic carotid atherosclerosis detection by positron emission tomography imaging
Aim: We investigated whether sodium fluoride (NaF) positron emission tomography (PET) were superior to fluorodeoxyglucose (FDG) PET in the detection of symptomatic carotid artery among stroke patients with carotid artery stenosis.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Jeong -Min Kim, Woo Hyun Paik, Byeong Jun Song, Eun Seoung Lee, Kwang -Yeol Park, Ju Won Seok, Oh -Sang Kwon Source Type: research

Detection of symptomatic carotid atherosclerosis from 18F-fluorodeoxyglucose and 18F-sodium fluoride positron emission tomography after stroke: A prospective study
Aim: We investigated whether symptomatic carotid atherosclerosis can be detected by using 18F-fluorodeoxyglucose (FDG) and 18F-sodium fluoride (NaF) positron emission tomography (PET) among cerebral infarction patients.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Jeong -Min Kim, Woo Hyun Paik, Byeong Jun Song, Eun Seoung Lee, Kwang -Yeol Park, Ju Won Seok Source Type: research

Noninvasive Assessment of Carotid Plaques Calcification by 18F-Sodium Fluoride Accumulation: Correlation with Pathology
This study aimed to correlate 18F-NaF accumulation with the histological characterization of vascular calcification in carotid plaques.
Source: Journal of Stroke and Cerebrovascular Diseases - March 16, 2018 Category: Neurology Authors: Yan Zhang, Hong Li, Yingqin Jia, Pengfei Yang, Feng Zhao, Wei Wang, Wenqing Liu, Guisheng Chen, Xiaoqing Zhuang, Juan Li Source Type: research

Correlation of noninvasive imaging of vulnerable carotid artery plaque using NaF and FDG PET/CT and black-blood MRI with cerebral ischemia on brain MRI
Conclusion] These preliminary results suggest that NaF uptake in carotid artery seems to correlate with cerebral ischemic changes.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Norikane, T., Yamamoto, Y., Maeda, Y., Okada, M., Nishiyama, Y. Tags: Cardiovascular Council YIA Symposium Source Type: research

Carotid artery atherosclerosis:plaque imaging in the personalized-medicine era
Conclusion: The evolution of atherosclerosis imaging and the emergence of new methods to measure atherosclerotic plaque vulnerability, particularly in the field of molecular imaging, have provided new insights into the pathophysiology of atherosclerosis and can be utilized in drug discovery and efficacy trials.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Gharavi, M., Saboury, B., Werner, T., Alavi, A. Tags: Educational Exhibits Source Type: research

18 F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques
Conclusions18F-NaF PET represents a different stage in the calcification process than CT. We observed a similar PET assessed18F-NaF uptake and pattern in culprit and non-culprit plaques of high-risk patients, indicating that this method may be of more value in early atherosclerotic stenosis development.
Source: Journal of Nuclear Cardiology - June 25, 2018 Category: Nuclear Medicine Source Type: research

Quantifying microcalcification activity in the thoracic aorta
ConclusionsAMA is a simple, rapid and reproducible method of quantifying global18F-NaF uptake across the ascending aorta and aortic arch that correlates with cardiovascular risk scores.
Source: Journal of Nuclear Cardiology - January 20, 2021 Category: Nuclear Medicine Source Type: research

Two-year change in 18F-sodium fluoride uptake in the carotid arteries of healthy subjects and angina pectoris patients
Conclusions: Slightly higher NaF uptake in the angina group indicated more ongoing carotid microcalcification at both time points in patients than in healthy subjects. The 2-year changes were very small in both groups, albeit with a tendency of slight decreases among healthy controls, suggesting a more dynamic, waxing and waning, process in these compared to a slow, but more consistent, progression in angina patients despite statin therapy in half of these.
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Piri, R., Lici, G., Riyahimanesh, P., Gerke, O., Alavi, A., Flemming Hoilund-Carlsen, P. Tags: Clinical Science Source Type: research