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Drug: Tamoxifen
Nutrition: Antidoxidants
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Total 24 results found since Jan 2013.
Comparative anticancer effects of Annona muricata Linn (Annonaceae) leaves and fruits on DMBA-induced breast cancer in female rats
CONCLUSION: These results confirm the anti-breast cancer effect of A. muricata, however, the aqueous fruit extract was more potent than the ethanolic leaves extract.PMID:37454062 | DOI:10.1186/s12906-023-04073-x
Source: Cancer Control - July 15, 2023 Category: Cancer & Oncology Authors: Kevine Kamga Silihe William Defo Mbou Judith Christiane Ngo Pambe Larissa Vanelle Kenmogne Laure Fotso Maptouom Marius Tr ésor Kemegne Sipping St éphane Zingue Dieudonn é Njamen Source Type: research
Hypothesizing the Green Synthesis of Tamoxifen Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer
The objective of this hypothesis is to prepare tamoxifen-loaded PEGylated NiO nanoparticles using green chemistry, tumbling the toxic effects of the conventional method of synthesis for targeted delivery to breast cancer cells. Significance of the research work: The significance of the work is to hypothesize a green method for the synthesis of NiO nanoparticles that are eco-friendly, cost-effective, decrease multidrug resistance, and can be used for targeted therapy. Garlic extract contains an organosulfur compound (Allicin) which has drug-metabolizing, anti-oxidant, and tumour growth inhibition effects. In breast cancer, ...
Source: Current Molecular Medicine - May 26, 2023 Category: Molecular Biology Authors: Neha Tyagi Tanya Ralli Asgar Ali Kanchan Kohli Source Type: research
Synthesis, identification and evaluation of molecular docking and experimental anti-cancer and antioxidant activity of new spiro four membered ring derivatives bearing 5-nitro isatin
Nat Prod Res. 2023 Mar 30:1-8. doi: 10.1080/14786419.2023.2195178. Online ahead of print.ABSTRACTSpiro-5-nitro isatino aza-β-lactams were produced by a [2 + 2] cycloaddition of 5-nitro isatin Schiff bases [1-5] with different aromatic isocyanate and thioisocyanate. 1HNMR and 13CNMR as well as FTIR spectroscopies, were used to identify the structures of the obtained compounds. These spiro-5-nitro isatin aza- β-lactams interest to us due to their potential antioxidant and anticancer properties. The MTT assay was used to examine in vitro bioactivity testing against breast cancer (MCF-7) cell lines. From result data, compoun...
Source: Natural Product Research - March 30, 2023 Category: Biochemistry Authors: Hala Ayad Mohamed Rasheed Suaad M H Al-Majidi Source Type: research
Screening of Anti-carcinogenic Properties of Phytocompounds from Allium ascalonicum for Treating Breast Cancer Through In Silico and In Vitro Approaches
Appl Biochem Biotechnol. 2022 Nov 4. doi: 10.1007/s12010-022-04202-1. Online ahead of print.ABSTRACTPlants, rich in phytocompounds, have been in usage since time immemorial for treating various diseases, namely, cancer. One such plant species, Allium ascalonicum (Shallot) belonging to Amaryllidaceae family is being studied here for its anti-carcinogenic properties against breast cancer. GC-MS characterization of A. ascalonicum exhibited 48 phytocompounds containing five peak phytocompounds and 13 phytocompounds with anti-carcinogenic properties. These 13 anti-carcinogenic phytocompounds were docked with three hormonal rece...
Source: Applied Biochemistry and Biotechnology - November 4, 2022 Category: Biochemistry Authors: Karunya Jenin Ravindranath Simon Durairaj Christian Hemalatha Srinivasan Source Type: research
Solid Self-Nano Emulsifying Nanoplatform Loaded with Tamoxifen and Resveratrol for Treatment of Breast Cancer
Pharmaceutics. 2022 Jul 18;14(7):1486. doi: 10.3390/pharmaceutics14071486.ABSTRACTThe solid self-nanoemulsifying drug delivery system (s-SNEDDS) is a growing platform for the delivery of drugs via oral route. In the present work, tamoxifen (TAM) was loaded in SNEDDS with resveratrol (RES), which is a potent chemotherapeutic, antioxidant, anti-inflammatory and P-gp inhibitor for enhancing bioavailability and to obtain synergistic anti-cancer effect against breast cancer. SNEDDS were developed using capmul MCM as oil, Tween 80 as surfactant and transcutol-HP as co-surfactant and optimized by central composite rotatable desig...
Source: Cell Research - July 27, 2022 Category: Cytology Authors: Nupur Shrivastava Ankit Parikh Rikeshwer Prasad Dewangan Largee Biswas Anita Kamra Verma Saurabh Mittal Javed Ali Sanjay Garg Sanjula Baboota Source Type: research
Alteration in glucose metabolism in the brain associated with tamoxifen treatment: Study in postmenopausal animal model
Toxicol Appl Pharmacol. 2022 Mar 27:116002. doi: 10.1016/j.taap.2022.116002. Online ahead of print.ABSTRACTTamoxifen is an effective breast cancer therapy in postmenopausal women. However, it can induce hyperglycemia through different mechanisms, such as the impairment of mitochondrial metabolism. Quercetin, a flavonoid with antioxidant potential, has beneficial effects on tamoxifen-induced adverse effects. Therefore, this study aimed to (1) investigate glucose concentration in blood, cerebrospinal fluid, cerebellum, cortex, and hippocampus of tamoxifen-treated ovariectomized female rats, non-treated and treated with querc...
Source: Toxicology and Applied Pharmacology - March 30, 2022 Category: Toxicology Authors: Su élyn Koerich Fernanda Coleraus Silva Ana Maria Itinose Paula Maria Quaglio Bellozi Fabiano Sandrini Sara Cristina Sagae Schneider Carla Brugin Marek Source Type: research
