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Specialty: Biochemistry
Drug: Dexamethasone
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Total 156 results found since Jan 2013.
Diosgenin prevents dexamethasone-induced myotube atrophy in C2C12 cells
Arch Biochem Biophys. 2023 Sep 16:109759. doi: 10.1016/j.abb.2023.109759. Online ahead of print.ABSTRACTSeveral pathophysiological abnormalities, including a sedentary lifestyle, chronic diseases, and oxidative stress, can contribute to muscle atrophy triggered by an imbalance in muscle protein synthesis and degradation. Resolving muscle atrophy is a critical issue as it can reduce the quality of life. Here, one of the promising functional food factors, diosgenin (a steroidal sapogenin) showed strong preventive activities against dexamethasone (Dex)-induced muscle atrophy, as determined by the expression levels and morphol...
Source: Archives of Biochemistry and Biophysics - September 18, 2023 Category: Biochemistry Authors: Yasukiyo Yoshioka Shiori Oishi Keita Onoda Katsumi Shibata Noriyuki Miyoshi Source Type: research
Anti-Allergic and Anti-inflammatory Effects of Bakuchiol on Ovalbumin-Induced Allergic Rhinitis in Mice
Appl Biochem Biotechnol. 2023 Sep 4. doi: 10.1007/s12010-023-04675-8. Online ahead of print.ABSTRACTAllergic rhinitis (AR) is a prevalent inflammatory disease primarily affecting the nasal mucosa and is caused by allergies. The common symptoms of AR include rhinorrhea, sneezing, itchy nose, congestion, teary eyes, and nasal rubbings. The present study assessed the beneficial properties of bakuchiol on OVA-induced AR in mice via the regulation of inflammatory responses. AR was induced by injecting (i.p.) OVA (50 µg) and aluminum hydroxide (1 mg) into mice at various time intervals. The bakuchiol treatment was done at dosag...
Source: Applied Biochemistry and Biotechnology - September 4, 2023 Category: Biochemistry Authors: Han Bing Yao Hesham S Almoallim Sulaiman Ali Alharbi Hui Feng Source Type: research
Four New Stilbene Derivatives Isolated from Gnetum latifolium var. funiculare Markgr. and Their Inhibition of NO Production in LPS-activated RAW264.7 Cells
Chem Biodivers. 2023 Aug 17:e202301166. doi: 10.1002/cbdv.202301166. Online ahead of print.ABSTRACTGnetum latifolium var. funiculare Markgr. is a medicinal plant and widely distributed in mountainous areas of Vietnam. Phytochemical investigation on the trunks of this plant afforded eight stilbene derivatives (1-8) including for new compounds (1-4). Their structures were determined based on extensive analyses of HR-ESI-MS, 1D and 2D NMR spectra. Among the isolates, compounds 1-3 showed moderate NO production inhibition in LPS-activated RAW264.7 cells with the IC50 values ranging from 46.81 to 68.10 μM, compounds 4 and 6 sh...
Source: Chemistry and Biodiversity - August 17, 2023 Category: Biochemistry Authors: Trinh Thi Thuy Nguyen Thi Thu Hoa Nguyen Thi Thuy Linh Ba Thi Cham Nguyen Thi Hoang Anh Nguyen Tuan Hiep Sabrina Adorisio Domenico V Delfino Ngo Anh Bang Bui Huu Tai Phan Van Kiem Source Type: research
Enhanced immune responses in dexamethasone immunosuppressed male rats supplemented with herbal extracts, chitosan nanoparticles, and their conjugates
Int J Biol Macromol. 2023 Aug 11:126170. doi: 10.1016/j.ijbiomac.2023.126170. Online ahead of print.ABSTRACTNowadays, the world is challenged with highly contagious diseases, one of their preliminary virulence mechanisms is the suppression of innate immunity. Therefore, promoting natural immunity is a good precautionary strategy. we investigated and compared the effects of several natural herbal extracts -Moringa oleifera, Ziziphus spina christi, and Saussurea costus, and chitosan nanoparticles (CS NPs)- as well as conjugated extracts with CS NPs on the immunological parameters of dexamethasone immunosuppressed (IS) male r...
Source: International Journal of Biological Macromolecules - August 13, 2023 Category: Biochemistry Authors: Selvia S Milad Sara E Ali Mahmoud Z Attia Marwa S Khattab Eman S El-Ashaal Hisham A Elshoky Afaf M Azouz Source Type: research
Undescribed Phenolic Glycosides from Syzygium attopeuense and Their Inhibition of Nitric Oxide Production
Chem Biodivers. 2023 Aug 2:e202301037. doi: 10.1002/cbdv.202301037. Online ahead of print.ABSTRACTFour undescribed phenolic glycosides including three stilbene derivatives (1 and 3) and sodium salt of 3 (2), and a chalcone glycoside (4), together with thirteen known compounds (5-17) were isolated from the leaves of Syzygium attopeuense (Gagnep.) Merr. & L.M.Perry. Their chemical structures were elucidated to be (Z)-gaylussacin (1), 6''-O-galloylgaylussacin sodium salt (2), 6''-O-galloylgaylussacin (3), 4'-O-[β-D-glucopyranosyl-(1→6)-glucopyranosyl]oxy-2'-hydroxy-6'-methoxydihydrochalcone (4), gaylussacin (5), pinosi...
Source: Chemistry and Biodiversity - August 2, 2023 Category: Biochemistry Authors: Phan Van Kiem Bui Hai Ninh Bui Huu Tai Nguyen Xuan Nhiem Pham Hai Yen Nguyen Huy Hoang Do Thi Trang Duong Thi Dung Nguyen Van Tuyen Le Tuan Anh Source Type: research
Dereplication of polar extracts from < em > Croton antisyphiliticus < /em > Mart. roots and its anti-inflammatory and antinociceptive potential
Nat Prod Res. 2023 Jul 10:1-5. doi: 10.1080/14786419.2023.2233672. Online ahead of print.ABSTRACTCroton antisyphiliticus Mart. is a plant popularly used in folk medicine by traditional communities from Brazilian savannah to treat general inflammation. According to ethnopharmacological data, this specie can be considered a source of biologically active molecules for the development of new drugs. Thereby, this study reports the results of the dereplication approach of C. antisyphiliticus roots extracts and the in vivo evaluation of its potential antinociceptive and anti-inflammatory in albino Swiss mice. Based on HPLC couple...
Source: Natural Product Research - July 10, 2023 Category: Biochemistry Authors: Jorge Luiz Souza Sim ão Stephanie Vilela Prado Alana Kelyene Pereira Gerso Pereira Alexandre N úbia Alves Mariano Teixeira Pires Gomide Marcia Matos da Silva Dionys de Souza Almeida Aline Nazareth Martins Daiany Priscilla Bueno da Silva Elson Alves da C Source Type: research
Galangin mitigates glucocorticoid-induced osteoporosis by activating autophagy of BMSCs via triggering the PKA/CREB signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2023 Jun 26. doi: 10.3724/abbs.2023063. Online ahead of print.ABSTRACTGlucocorticoid-induced osteoporosis (GIOP), one of the most common and serious adverse effects associated with glucocorticoid administration, manifests as decreased bone formation and increased bone resorption, eventually culminating in bone loss. Galangin (GAL) is a flavonoid extracted from the medicinal herbal galangal that possesses a variety of pharmacological activities and can inhibit osteoclastogenesis. However, the effects of GAL on GIOP remain unclear. Our study aims to explore the effects of GAL on GIOP in m...
Source: Acta Biochimica et Biophysica Sinica - June 27, 2023 Category: Biochemistry Authors: Chenying Zeng Shan Wang Huimin Gu Fenglei Chen Ziming Wang Jinteng Li Zhongyu Xie Pei Feng Huiyong Shen Yanfeng Wu Source Type: research
Elsholblanosides A-D, Four New Oleuropeic Acid Derivatives Isolated from Elsholtzia blanda and Their Inhibition of NO Production in LPS-activated RAW264.7 Cells
Chem Biodivers. 2023 Jun 21:e202300785. doi: 10.1002/cbdv.202300785. Online ahead of print.ABSTRACTPhytochemical investigation on the aerial parts of Elsholtzia blanda Benth. afforded four new oleuropeic acid derivatives (1-4), named as elsholblanosides A-D, respectively, together with 11 known compounds (5-15). Their structures were determined based on extensive analyses of HR-ESI-MS, 1D and 2D NMR, and ECD spectra. Compounds 1-4 and 14 showed moderate NO production inhibition in LPS-activated RAW264.7 cells with their IC50 values ranging from 23.2 to 86.33 μM, compared to that of the positive control compound, dexametha...
Source: Chemistry and Biodiversity - June 21, 2023 Category: Biochemistry Authors: Duong Thi Dung Do Thi Trang Pham Hai Yen Nguyen Huy Hoang Bui Huu Tai Phan Van Kiem Source Type: research
Pelliolatifolia A-D, Four Undescribed Compounds from Pellionia latifolia Boerl. and Their Nitric Oxide Production Inhibitory Activity
Chem Biodivers. 2023 Jun 21:e202300731. doi: 10.1002/cbdv.202300731. Online ahead of print.ABSTRACTFour undescribed compounds (1-4) named pelliolatifolias A-D together with seven known compounds trans-clovamide (5), N-trans-caffeoyl-4-hydroxyphenylalanine methyl ester (6), N-trans-caffeoyl-3,4-dihydroxyphenylalanine methyl ester (7), luteolin 4'-O-β-D-glucopyrannoside (8), cis-syringin (9), trans-syringin (10), and citroside A (11) have been isolated from the methanol extract of the Pellionia latifolia leaves. Their chemical structures were elucidated based on extensive analyses of HR-ESI-MS, 1D and 2D NMR, and ECD spectr...
Source: Chemistry and Biodiversity - June 21, 2023 Category: Biochemistry Authors: Tran Thi Thu Ha Nguyen Thi Cuc Bui Huu Tai Khuat Huu Trung Tran Dang Khanh Phan Van Kiem Source Type: research
