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Drug: Dexamethasone
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Total 6562 results found since Jan 2013.
Effect of miR-381-3p/FGF7 axis on the osteogenic differentiation of bone marrow mesenchymal stem cells through MEK/ERK signaling pathway
Tissue Cell. 2022 Apr 1;76:101791. doi: 10.1016/j.tice.2022.101791. Online ahead of print.ABSTRACTAlthough microRNAs (miRNAs) exert an important role in the osteogenesis of mesenchymal stem cells (MSCs), the effect of miR-381-3p on the osteogenic differentiation in MBD‑MSCs is still unclear. The BMMSCs from patients with MBD (MBD‑MSC) or normal participants (Normal‑MSC) were isolated and induced to differentiation with dexamethasone. BMMSCs were transfected with miR-381-3p mimic, miR-381-3p inhibitor, and FGF7 siRNA to regulate the expression of miR-381-3p or FGF7. The direct binding between miR-381-3p and FGF7 was p...
Source: Tissue and Cell - April 15, 2022 Category: Cytology Authors: Ling Qiu Jiao Cai Nan Zhang Lei Ma Fang-Yi Fan Xiao-Ming Li Source Type: research
Glucocorticoid receptor modulates myeloid-derived suppressor cell function via mitochondrial metabolism in immune thrombocytopenia
In conclusion, our study indicated that impaired aerobic metabolism in MDSCs participates in the pathogenesis of glucocorticoid resistance in ITP and that intact control of MDSC metabolism by GR contributes to the homeostatic regulation of immunosuppressive cell function.PMID:35414712 | DOI:10.1038/s41423-022-00859-0
Source: Cellular and Molecular Immunology - April 13, 2022 Category: Molecular Biology Authors: Yu Hou Jie Xie Shuwen Wang Daqi Li Lingjun Wang Haoyi Wang Xiaofei Ni Shaoqiu Leng Guosheng Li Ming Hou Jun Peng Source Type: research
Effect of miR-381-3p/FGF7 axis on the osteogenic differentiation of bone marrow mesenchymal stem cells through MEK/ERK signaling pathway
Tissue Cell. 2022 Apr 1;76:101791. doi: 10.1016/j.tice.2022.101791. Online ahead of print.ABSTRACTAlthough microRNAs (miRNAs) exert an important role in the osteogenesis of mesenchymal stem cells (MSCs), the effect of miR-381-3p on the osteogenic differentiation in MBD‑MSCs is still unclear. The BMMSCs from patients with MBD (MBD‑MSC) or normal participants (Normal‑MSC) were isolated and induced to differentiation with dexamethasone. BMMSCs were transfected with miR-381-3p mimic, miR-381-3p inhibitor, and FGF7 siRNA to regulate the expression of miR-381-3p or FGF7. The direct binding between miR-381-3p and FGF7 was p...
Source: Tissue and Cell - April 15, 2022 Category: Cytology Authors: Ling Qiu Jiao Cai Nan Zhang Lei Ma Fang-Yi Fan Xiao-Ming Li Source Type: research
Glucocorticoid receptor modulates myeloid-derived suppressor cell function via mitochondrial metabolism in immune thrombocytopenia
In conclusion, our study indicated that impaired aerobic metabolism in MDSCs participates in the pathogenesis of glucocorticoid resistance in ITP and that intact control of MDSC metabolism by GR contributes to the homeostatic regulation of immunosuppressive cell function.PMID:35414712 | DOI:10.1038/s41423-022-00859-0
Source: Cellular and Molecular Immunology - April 13, 2022 Category: Molecular Biology Authors: Yu Hou Jie Xie Shuwen Wang Daqi Li Lingjun Wang Haoyi Wang Xiaofei Ni Shaoqiu Leng Guosheng Li Ming Hou Jun Peng Source Type: research
Mouse mesoderm-specific transcript inhibits adipogenic differentiation and induces trans-differentiation into hepatocyte-like cells in 3T3-L1 preadiocytes
BMC Res Notes. 2022 May 10;15(1):164. doi: 10.1186/s13104-022-06051-x.ABSTRACTOBJECTIVE: The mesoderm-specific transcript (Mest) is an imprinted gene that is transcribed from the paternal allele. It is a marker of adipose tissue expansion; however, it is uncertain whether Mest expression promotes or suppresses adipogenic differentiation. To elucidate the effects of Mest expression on adipogenic differentiation, we transfected an expression vector or siRNA for mouse Mest into 3T3-L1 mouse preadipocyte cell line.RESULTS: In differentiated 3T3-L1 adipocytes, Mest overexpression decreased lipid accumulation. Conversely, gene s...
Source: Cell Research - May 10, 2022 Category: Cytology Authors: Yoshito Kadota Takashige Kawakami Masao Sato Shinya Suzuki Source Type: research
Upregulation of hepatic CD36 via glucocorticoid receptor activation contributes to dexamethasone-induced liver lipid metabolism disorder in mice
Toxicol Lett. 2022 May 16:S0378-4274(22)00091-1. doi: 10.1016/j.toxlet.2022.05.003. Online ahead of print.ABSTRACTGlucocorticoids such as dexamethasone (DEX) are widely prescribed to treat numerous conditions and diseases. However, glucocorticoid-induced liver lipid metabolism disorder, even nonalcoholic fatty liver disease, has caused extensive attention. Since fatty acid transporters such as CD36 and FATP play crucial roles in hepatic fatty acid uptake, this work examined their potential involvement in DEX-induced liver lipid accumulation. Chronic DEX administration (1-5mg/kg/day over 28 days) induced hepatic lipid accum...
Source: Toxicology Letters - May 19, 2022 Category: Toxicology Authors: Mingyang Chen Mengru Bai Yaodong Yi Shuanghui Lu Jun Luo Ping Li Hengbin Zhang Huidi Jiang Hui Zhou Source Type: research
Efficacy of COVID-19 treatments among geriatric patients: a systematic review
CONCLUSION: No agent is known to be effective for preventing COVID-19 after exposure to the virus. Further research is needed to ensure safety and efficacy of each of the reviewed interventions for older adults.PMID:35677110 | PMC:PMC9168946 | DOI:10.1177/20499361221095666
Source: Adv Data - June 9, 2022 Category: Epidemiology Authors: Helen Senderovich Danusha Vinoraj Madeline Stever Sarah Waicus Source Type: research
A novel BMP2 secretagogue ameliorates glucocorticoid induced oxidative stress in osteoblasts by activating NRF2 dependent survival while promoting Wnt/ β-catenin mediated osteogenesis
Free Radic Biol Med. 2022 Aug 10:S0891-5849(22)00514-7. doi: 10.1016/j.freeradbiomed.2022.08.007. Online ahead of print.ABSTRACTIn our previous study, a novel BMP2 secretagogue was synthesized belonging to a class of galloyl conjugates of flavanones, with remarkable osteogenic potential that promoted bone regeneration. We aimed to establish the protective effect of our compound against bone loss that co-exists with excess Glucocorticoid (GC) therapy. GC therapy induces osteoblast damage leading to apoptosis by increasing reactive oxygen species (ROS). Our results delineate that compound 5e (a BMP2 secretagogue) activates N...
Source: Free Radical Biology and Medicine - August 13, 2022 Category: Biology Authors: Divya Rai Ashish Kumar Tripathi Anirban Sardar Alka Raj Pandey Shradha Sinha Kunal Chutani Geeta Dhaniya Priyanka Kothari Koneni V Sashidhara Ritu Trivedi Source Type: research
