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Drug: Dexamethasone
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Total 6433 results found since Jan 2013.
Systematic review and meta-analysis of interleulin-6 inhibitors in reducing mortality for hospitalized patients with COVID-19
CONCLUSIONS: A benefit in mortality for interleukine-6 inhibitors was found, but with important differences among the scenarios analyzed in the clinical trials. Positive results are mainly caused by two randomized clinical trials which are similar in concomitant use of steroids and veryhigh mortality in critical patents. Sarilumab was poorly represented in the meta-analysis. Nevertheless, an association between the benefit and the critical/non-critical condition was not found. More randomized clinical trials, mainly focused in atients at high mortality risk, are needed to confirm the benefit of interleukine- 6 inhibitors f...
Source: Farmacia Hospitalaria - October 2, 2022 Category: Drugs & Pharmacology Authors: Emilio Jes ús Alegre-Del-Rey Silvia F énix-Caballero Francisco Javier Salmer ón-Navas Manuel David Gil-Sierra Jes ús Francisco Sierra-Sánchez Ram ón L Díaz-Alersi Rosety Source Type: research
Keratin films for ocular surface reconstruction: Wound healing in an in-vivo model
This study, further explored the biocompatibility of Keratin Film (KF) and its ability to sustain corneal epithelial wound healing. In three equal groups of 5 New Zeeland white rabbits a 4 mm superficial keratectomy was created in the right eye. Five eyes received a KF, five a human AM graft and the remaining five no implant. All eyes were treated with ofloxacin and dexamethasone eye drops and followed up for 10 days. Corneal fluorescein staining, vascularization, and transparency were assessed using slit lamp biomicroscopy according to a standardized grading score during and at the end of follow-up. The corneal-scleral-bu...
Source: Experimental Eye Research - December 23, 2022 Category: Opthalmology Authors: M Borrelli J Witt M Roth S Reichl P Bradenbrink M Schoppe S Schrader G Geerling Source Type: research
Glucocorticoids for croup in children
CONCLUSIONS: The evidence that glucocorticoids reduce symptoms of croup at two hours, shorten hospital stays, and reduce the rate of return visits or (re)admissions has not changed in this update. A smaller dose of 0.15 mg/kg of dexamethasone may be as effective as the standard dose of 0.60 mg/kg. More RCTs are needed to strengthen the evidence for effectiveness of low-dose dexamethasone at 0.15 mg/kg to treat croup.PMID:36626194 | DOI:10.1002/14651858.CD001955.pub5
Source: Cochrane Database of Systematic Reviews - January 10, 2023 Category: General Medicine Authors: Alex Aregbesola Clara M Tam Asha Kothari Me-Linh Le Mirna Ragheb Terry P Klassen Source Type: research
Occurrence of endocrine disruptors in Malaysia's water systems: A scoping review
This report aims to describe the occurrence of EDCs and their locations. Literature search was conducted electronically in two databases (PubMed and Scopus). A total of 41 peer-reviewed articles published between January 2000 and May 2021 were selected. Most of the articles dealt with pharmaceuticals (16), followed by pesticides (7), hormones (7), mixed species (7), and plasticisers (4). Most studies (40/41) were conducted in Peninsular Malaysia, with 60.9% in the central region and almost half (48.8%) in the Selangor State. Only one study was conducted in the northern region and East Malaysia. The Langat River, the Klang ...
Source: Environmental Pollution - January 22, 2023 Category: Environmental Health Authors: Nurul Amalina Khairul Hasni Zurahanim Fasha Anual Siti Aishah Rashid Syahidiah Syed Abu Thahir Yuvaneswary Veloo Khor Sok Fang Mohamad Iqbal Mazeli Source Type: research
Isolated relapse of plasma cell leukemia in the central nervous systems: a case report and literature review
Int J Hematol. 2023 Feb 3. doi: 10.1007/s12185-023-03545-7. Online ahead of print.ABSTRACTPlasma cell leukemia is a rare yet aggressive form of multiple myeloma characterized by high levels of plasma cells circulating in the peripheral blood. We recently experienced a case of plasma cell leukemia that had been in stringent complete remission for nine years after autologous stem cell transplantations with subsequent courses of lenalidomide maintenance therapy, and then relapsed as an extramedullary plasmacytoma in the central nervous system. Assessment of the bone marrow did not prove proliferation of plasma cells at relaps...
Source: International Journal of Hematology - February 3, 2023 Category: Hematology Authors: Takafumi Obo Ken Morita Yutaro Sumida Kumi Nakazaki-Watadani Masako Ikemura Koichiro Yasaka Osamu Abe Hirokazu Takami Shunsaku Takayanagi Shota Tanaka Hiroaki Maki Yosuke Masamoto Akiyoshi Miwa Mineo Kurokawa Source Type: research
Efficacy of Preemptive Dexamethasone versus Methylprednisolone in the Management of Postoperative Discomfort and Pain after Mandibular Third Molar Surgery: A Systematic Review and Meta-Analysis
ScientificWorldJournal. 2023 Apr 30;2023:7412026. doi: 10.1155/2023/7412026. eCollection 2023.ABSTRACTThe corticosteroids have been used for preemptive management of surgical sequelae after mandibular third molar extraction. The aim of this article was to review the efficacy of methylprednisolone versus dexamethasone in the management of postsurgical pain, swelling, and trismus after mandibular third molar surgery. Randomized, double-blinded studies from PubMed, CINAHL, Scopus, DOSS, Cochrane central, and Web of Science were identified by using a search strategy. Randomized controlled trials evaluating the efficacy of use ...
Source: The Scientific World Journal - May 11, 2023 Category: Science Authors: Anupam Singh Kalyana Chakravarthy Pentapati Murali Venkata Rama Mohan Kodali Komal Smriti Vathsala Patil Gandham Lekha Chowdhary Srikanth Gadicherla Source Type: research
Ponatinib vs. Imatinib as Frontline Treatment for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Matching Adjusted Indirect Comparison
ConclusionIn adults with newly diagnosed Ph + ALL, first-line treatment with ponatinib was associated with better outcomes than first-line treatment with imatinib.
Source: Advances in Therapy - May 19, 2023 Category: Drugs & Pharmacology Source Type: research
