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Infectious Disease: Coronavirus
Drug: Dexamethasone
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Total 315 results found since Jan 2013.
Prognostic factors for poor outcomes in patients with severe COVID-19 treated with remdesivir plus dexamethasone in Taiwan
CONCLUSION: High disease severity on admission and delayed initiation of remdesivir therapy were associated with poor outcomes in COVID-19 patients treated with remdesivir and dexamethasone.PMID:37696685 | DOI:10.1016/j.jmii.2023.08.008
Source: Journal of Microbiology, Immunology, and Infection - September 11, 2023 Category: Microbiology Authors: Yi-Hsuan Lai Yi-Chih Lee I-Ren Chen Shih-Neng Lin Yuh-Lih Chang Chih-Chia Lu Ping-Feng Wu Yi-Tsung Lin Source Type: research
Molecular mechanisms and treatment responses of pulmonary fibrosis in severe COVID-19
CONCLUSIONS: ICU patients with COVID-19 who develop PF exhibit upregulated coagulation, inflammation, and neutrophil extracellular trap-related pathways as well as prolonged ICU length-of-stay and mortality. This study indicates that early dexamethasone treatment neither influences the incidence or clinical course of PF, nor clinical outcomes.PMID:37559053 | DOI:10.1186/s12931-023-02496-1
Source: Respiratory Care - August 9, 2023 Category: Respiratory Medicine Authors: Emma J Kooistra Kilian Dahm Antonius E van Herwaarden Jelle Gerretsen Melanie Nuesch Germano Karoline Mauer Ruben L Smeets Sjef van der Velde Maarten J W van den Berg Johannes G van der Hoeven Anna C Aschenbrenner Joachim L Schultze Thomas Ulas Matthijs K Source Type: research
A Comparison of the Effects of Dexamethasone and Methylprednisolone, Used on Level-3 Intensive Care COVID-19 Patients, on Mortality: A Multi-Center Retrospective Study
CONCLUSION: Corticosteroids are shown to be beneficial in critical COVID-19, but the role of early corticosteroids in mild COVID-19 patients remains unclear. The anti-inflammatory effects of corticosteroids may have a positive effect by reducing mortality in severe COVID-19 patients. Although dexamethasone was first used for this purpose, methylprednisolone was found to be as effective at standard doses. Methylprednisolone administered at standard doses was associated with greater PaO2/FiO2 ratios than dexamethasone, especially in the severe group requiring MV. High dose pulse steroid doses are closely associated with mort...
Source: J Korean Med Sci - July 25, 2023 Category: General Medicine Authors: Ahmet Sari Osman Ekinci Kemal Tolga Sara çoğlu Recep Bal ık Mesut Aslan Yelda Bal ık Ceren Önal Murat Aslan Semra Cevher Aylin Parmaks ız Şeule Vatansever M ünire Canan Çicek Özge Sayın Ayan Gaye Şensöz Çelik A çelya Toprak Mehmet Y ılmaz Source Type: research
Seasonal coronavirus infections trigger NLRP3 inflammasome activation in macrophages but is therapeutically targetable
Antiviral Res. 2023 Jul 15:105674. doi: 10.1016/j.antiviral.2023.105674. Online ahead of print.ABSTRACTSeasonal coronaviruses widely circulate in the global population, and severe complications can occur in specific vulnerable populations. Little is known on their pathogenic mechanisms and no approved treatment is available. Here, we present anecdotal evidence that the level of IL-1β, a hallmark of inflammasome activation, appears elevated in a subset of seasonal coronavirus infected patients. We found that cultured human macrophages support the full life cycle of three cultivatable seasonal coronaviruses. Their infection...
Source: Antiviral Research - July 17, 2023 Category: Virology Authors: Yang Li Yining Wang Yunlong Li Annemarie C de Vries Pengfei Li Maikel P Peppelenbosch Qiuwei Pan Source Type: research
The Effects of Remdesivir and Dexamethasone on Renal Sirtuin-1 Expression and Renal Function in Male Rats
Appl Biochem Biotechnol. 2023 May 11. doi: 10.1007/s12010-023-04529-3. Online ahead of print.ABSTRACTRemdesivir (REM) and dexamethasone (DEX) both have been used to treat coronavirus disease 2019 (COVID-19). The present study aimed to evaluate the effects of REM and DEX on kidney structure and function with particular focus on the probable renal sirtuin-1 (SIRT1) expression alteration in rats. Twenty-four male Wistar rats were divided into four groups, as follows: group A (control) received normal saline (5 mL/kg/day for 10 days); group B (REM) received REM (17 mg/kg/day on the first day, and 8.5 mg/kg/day on the 2nd-10th ...
Source: Applied Biochemistry and Biotechnology - May 11, 2023 Category: Biochemistry Authors: Sepideh Danaiyan Mehran Mesgari Abbasi Sina Raeisi Hassan Argani Amir Ghorbanihaghjo Dariush Shanehbandi Leila Roshangar Haniyeh Poursistany Sara Abedi Jamal Mohammadian Mona Bahremani Nadereh Rashtchizadeh Source Type: research
