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Drug: Dexamethasone
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Total 3669 results found since Jan 2013.
Second-line tests in the differential diagnosis of neoplastic and non-neoplastic hypercortisolism: a systematic review and meta-analysis
DiscussionBoth Dex-CRH and Desmopressin tests can be valid tools in helping discrimination between NNH/pCS and CS. Further studies are needed on this topic, possibly focusing on mild Cushing ’s Disease and well-characterized NNH/pCS patients.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022359774, identifier CRD42022359774.
Source: Journal of Endocrinological Investigation - September 22, 2023 Category: Endocrinology Source Type: research
Fraxin in Combination with Dexamethasone Attenuates LPS-Induced Liver and Heart Injury and Their Anticytokine Activity in Mice
CONCLUSIONS: All interventions used in this study significantly reduced interleukin-8 (IL-8) levels and reduced LPS-induced liver and cardiac damage. The combination (FD) did not result in an evident superiority of either agent. More research is required to identify the possible usefulness of these agents in treating hyperinflammatory diseases, such as cytokine storms, in future clinical practice.PMID:37727368 | PMC:PMC10506875 | DOI:10.1155/2023/5536933
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Nada Sahib Shaker Hayder Bahaa Sahib Source Type: research
High-throughput screening as a drug repurposing strategy for poor outcome subgroups of pediatric B-cell precursor Acute Lymphoblastic Leukemia
Biochem Pharmacol. 2023 Sep 15:115809. doi: 10.1016/j.bcp.2023.115809. Online ahead of print.ABSTRACTAlthough a great cure rate has been achieved for pediatric BCP-ALL, approximately 15% of patients do not respond to conventional chemotherapy and experience disease relapse. A major effort to improve the cure rates by treatment intensification would result in an undesirable increase in treatment-related toxicity and mortality, raising the need to identify novel therapeutic approaches. High-throughput (HTP) drug screening enables the profiling of patients' responses in vitro and allows the repurposing of compounds currently ...
Source: Biochemical Pharmacology - September 17, 2023 Category: Drugs & Pharmacology Authors: Athanasios Oikonomou Luigia Valsecchi Manuel Quadri Titus Watrin Katerina Scharov Simona Procopio Jia-Wey Tu Melina Vogt Angela Maria Savino Daniela Silvestri Maria Grazia Valsecchi Andrea Biondi Arndt Borkhardt Sanil Bhatia Giovanni Cazzaniga Grazia Fazi Source Type: research
Pooled Analysis of Studies Evaluating Fosnetupitant and Risk Factors for Cisplatin-Induced Nausea and Vomiting During the Extended Overall Phase
CONCLUSION: This analysis revealed that fosnetupitant could have long-acting antiemetic potency (> 120 h) and indicated the importance of antiemetic therapy at 0-120 h for CINV up to 168 h after chemotherapy.PMID:37715851 | DOI:10.1007/s12325-023-02648-1
Source: Adv Data - September 16, 2023 Category: Epidemiology Authors: Naoki Inui Yukihiro Toi Yasuto Yoneshima Masahiro Morise Akito Hata Kaoru Kubota Toshiaki Saeki Tomohide Tamura Source Type: research
Safety of antenatal predniso(lo)ne and dexamethasone on fetal, neonatal and childhood outcomes: a systematic review
CONCLUSIONS: Based on the limited evidence found in this systematic review, predniso(lo)ne may have less side-effects compared to dexamethasone in short- and long-term outcomes. Current literature shows minimal risk of side-effects in the newborn by administration of a prenatal predniso(lo)ne dose of up to 10 mg per day.PMID:37715964 | DOI:10.1210/clinem/dgad547
Source: The Journal of Clinical Endocrinology and Metabolism - September 16, 2023 Category: Endocrinology Authors: Elise M A Slob Jacqueline U M Termote Janna W Nijkamp Hetty J Van der Kamp Erica L T van den Akker Source Type: research
Resistance exercise alleviates dexamethasone-induced muscle atrophy via Sestrin2/MSTN pathway in C57BL/6J mice
CONCLUSION: Taken together, our results indicated that Sestrin2 may serve as an effective molecule that mimics the protective effect of resistance exercise on dexamethasone-induced muscle atrophy.PMID:37709247 | DOI:10.1016/j.yexcr.2023.113779
Source: Experimental Cell Research - September 14, 2023 Category: Cytology Authors: Yang Yang Xuege Yang Yating Huang Sujuan Liu Yanmei Niu Li Fu Source Type: research
Unveiling pro-angiogenesis and drug delivery using dual-bio polymer with bio-ceramic based nanocomposite hydrogels
Chemosphere. 2023 Sep 8:140131. doi: 10.1016/j.chemosphere.2023.140131. Online ahead of print.ABSTRACTIn regenerative medicine, blood vessel development is of utmost importance as it enables the restoration of blood flow to tissues, and facilitate rapid vascularization in clinical tissue-engineered grafts. Herein, we fabricate the nanocomposite hydrogels from BG, alginate, Polyethylene glycol (PEG) and Dexamethasone (DEX) for the dual applications of drug delivery and angiogenesis assay. The hydrogels were fabricated through cross-linking approach and termed as alginate/PEG (A), alginate/PEG/clinophosinaite (AC), and algin...
Source: Chemosphere - September 10, 2023 Category: Chemistry Authors: K Elakkiya P Bargavi S Balakumar Source Type: research
Topical formulations of Aprepitant are safe and effective in relieving pain and inflammation, and drive neural regeneration
CONCLUSIONS: Aprepitant X formulation is a promising candidate for the treatment of pain associated with inflammation of the ocular surface.PMID:37690516 | DOI:10.1016/j.jtos.2023.09.004
Source: The Ocular Surface - September 10, 2023 Category: Opthalmology Authors: Filippo Bonelli Ibrahim Demirsoy Romina Mayra Lasagni Vitar Philippe Fonteyne Giulio Ferrari Source Type: research
