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Drug: Aspirin
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Total 3546 results found since Jan 2013.
A cardiovascular polypill for secondary stroke prevention in a tertiary centre in Ghana (SMAART): a phase 2 randomised clinical trial
Lancet Glob Health. 2023 Oct;11(10):e1619-e1628. doi: 10.1016/S2214-109X(23)00347-9.ABSTRACTBACKGROUND: A cardiovascular polypill containing generic drugs might facilitate sustained implementation of and adherence to evidence-based treatments, especially in resource-limited settings. However, the impact of a cardiovascular polypill in mitigating atherosclerotic risk among stroke survivors has not been assessed. We aimed to compare a polypill regimen with usual care on carotid intima-media thickness (CIMT) regression after ischaemic stroke.METHODS: In SMAART, a phase 2 parallel, open-label, assessor-masked, randomised clini...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Fred Stephen Sarfo Jenifer Voeks Sheila Adamu Benedict Apaw Agyei Manolo Agbenorku Nyantakyi Adu-Darko Mercy Adomah Oteng Vida Obese Rexford Adu Gyamfi Nathaniel Adusei Mensah Raelle Tagge Michael Ampofo Samuel Amoabeng Kontoh Samuel Blay Nguah Bruce Ovbi Source Type: research
BPDE-DNA adduct formation and alterations of mRNA, protein, and DNA methylation of CYP1A1, GSTP1, and GSTM1 induced by benzoapyrene and the intervention of aspirin in mice
In conclusion, B[a]P induced BPDE-DNA adduct formation in all organs in mice and altered the mRNA, protein, and DNA methylation levels in CYP1A1, GSTP1, and GSTM1 in an organ-dependent pattern, which could be related to the organ toxicity and mechanism of B[a]P. ASP intervention may be an effective measure to prevent B[a]P toxicity. The findings provide scientific evidence for further study on the organ toxicity and mechanisms of B[a]P.PMID:37730975 | DOI:10.1007/s11356-023-29878-8
Source: Environmental Science and Pollution Research International - September 21, 2023 Category: Environmental Health Authors: Aixiang Liu Xin Li Lisha Zhou Xiaoqing Yan Na Xia Zhanfei Song Jingjing Cao Zhongsuo Hao Zhihong Zhang Ruifeng Liang Hongmei Zhang Source Type: research
Atherosclerosis as a Risk Factor for IBD: A Population-Based Case-Control Study
CONCLUSIONS: A history of an atherosclerotic-related condition is associated with increased odds of developing IBD, particularly among older adults. Future studies should investigate whether drugs targeting atherosclerotic-related inflammation may prevent IBD in higher-risk individuals.PMID:37721310 | DOI:10.14309/ajg.0000000000002502
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Adam S Faye Jordan Axelrad Jiangwei Sun Jonas Halfvarson Jonas S öderling Ola Ol én Jonas F Ludvigsson Source Type: research
Single-center experience of endovascular treatment for patients with progressive posterior circulation cerebral infarction exceeding 24 h
CONCLUSION: In patients with progressive posterior circulation cerebral infarction caused by vertebral basilar artery occlusion, ET is effective and safe even if the time from onset to puncture exceeds 24 h.PMID:37719319 | PMC:PMC10505061 | DOI:10.2478/abm-2023-0046
Source: Biomed Res - September 18, 2023 Category: Research Authors: Guangfeng Zhao Xiongjun He Yajie Liu Liang Zhang Kaifeng Li Source Type: research
Atherosclerosis as a Risk Factor for IBD: A Population-Based Case-Control Study
CONCLUSIONS: A history of an atherosclerotic-related condition is associated with increased odds of developing IBD, particularly among older adults. Future studies should investigate whether drugs targeting atherosclerotic-related inflammation may prevent IBD in higher-risk individuals.PMID:37721310 | DOI:10.14309/ajg.0000000000002502
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Adam S Faye Jordan Axelrad Jiangwei Sun Jonas Halfvarson Jonas S öderling Ola Ol én Jonas F Ludvigsson Source Type: research
Single-center experience of endovascular treatment for patients with progressive posterior circulation cerebral infarction exceeding 24 h
CONCLUSION: In patients with progressive posterior circulation cerebral infarction caused by vertebral basilar artery occlusion, ET is effective and safe even if the time from onset to puncture exceeds 24 h.PMID:37719319 | PMC:PMC10505061 | DOI:10.2478/abm-2023-0046
Source: Biomed Res - September 18, 2023 Category: Research Authors: Guangfeng Zhao Xiongjun He Yajie Liu Liang Zhang Kaifeng Li Source Type: research
Risk factors and a prediction model for unruptured intracranial aneurysms in patients with ischemic stroke using carotid intima-media thickness and systemic atherosclerosis
CONCLUSION: The findings revealed that the risk factors for UIA in patients with IS included aspirin use, elevated CRP level, and smaller carotid IMT, and the predictive value of the prediction model was relatively better.PMID:37706007 | PMC:PMC10495834 | DOI:10.3389/fneur.2023.1227673
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Gaiming Gao Dezhi Kang Jinning Zhang Zhixian Jiang Xueyang He Yanyu Wu Source Type: research
AEE alleviates ox-LDL-induced lipid accumulation and inflammation in macrophages
Biomed Pharmacother. 2023 Sep 12;167:115486. doi: 10.1016/j.biopha.2023.115486. Online ahead of print.ABSTRACTAtherosclerosis is a chronic immune inflammatory disease. Aspirin eugenol ester (AEE) is a novel safe and non-toxic compound with many pharmacological effects such as anti-inflammatory, anti-hyperlipidemic and anti-thrombotic action. In order to investigate the effect of AEE on the inhibition of aortic lipid plaque formation and macrophage-derived foam cell formation induced by oxidized low density lipoprotein (ox-LDL), in vivo atherosclerosis model by feeding ApoE-/- mice with a high-fat diet and foam cells format...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 14, 2023 Category: Drugs & Pharmacology Authors: Ya-Xian Liu Xi-Wang Liu Ya-Jun Yang Shi-Hong Li Li-Xia Bai Wen-Bo Ge Xiao Xu Cun Li Jian-Yong Li Zhe Qin Source Type: research
Plasma protein signatures for high on-treatment platelet reactivity to aspirin and clopidogrel in peripheral artery disease
CONCLUSIONS: A plasma protein signature, including eight targets involved in proatherogenic dysfunction of blood cell-vasculature interaction, coagulation and cell death, is associated with HTPR (aspirin and/or clopidogrel) in PAD. This may serve as important systems-based determinants of poor platelet responsiveness to aspirin and/or clopidogrel in PAD and other cardiovascular diseases and may contribute to identify novel treatment strategies.PMID:37708596 | DOI:10.1016/j.thromres.2023.08.017
Source: Cell Research - September 14, 2023 Category: Cytology Authors: G Baidildinova A Pallares Robles V Ten Cate B M M Kremers S Heitmeier H Ten Cate B M E Mees H M H Spronk P S Wild A J Ten Cate-Hoek K Jurk Source Type: research
AEE alleviates ox-LDL-induced lipid accumulation and inflammation in macrophages
Biomed Pharmacother. 2023 Sep 12;167:115486. doi: 10.1016/j.biopha.2023.115486. Online ahead of print.ABSTRACTAtherosclerosis is a chronic immune inflammatory disease. Aspirin eugenol ester (AEE) is a novel safe and non-toxic compound with many pharmacological effects such as anti-inflammatory, anti-hyperlipidemic and anti-thrombotic action. In order to investigate the effect of AEE on the inhibition of aortic lipid plaque formation and macrophage-derived foam cell formation induced by oxidized low density lipoprotein (ox-LDL), in vivo atherosclerosis model by feeding ApoE-/- mice with a high-fat diet and foam cells format...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 14, 2023 Category: Drugs & Pharmacology Authors: Ya-Xian Liu Xi-Wang Liu Ya-Jun Yang Shi-Hong Li Li-Xia Bai Wen-Bo Ge Xiao Xu Cun Li Jian-Yong Li Zhe Qin Source Type: research
Risk factors and a prediction model for unruptured intracranial aneurysms in patients with ischemic stroke using carotid intima-media thickness and systemic atherosclerosis
CONCLUSION: The findings revealed that the risk factors for UIA in patients with IS included aspirin use, elevated CRP level, and smaller carotid IMT, and the predictive value of the prediction model was relatively better.PMID:37706007 | PMC:PMC10495834 | DOI:10.3389/fneur.2023.1227673
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Gaiming Gao Dezhi Kang Jinning Zhang Zhixian Jiang Xueyang He Yanyu Wu Source Type: research
Early Computed Tomography Coronary Angiography and Preventative Treatment in Patients with Suspected Acute Coronary Syndrome A secondary analysis of the RAPID-CTCA trial
CONCLUSIONS: Prescription patterns of preventative treatment varied during index hospitalisation in patients with suspected acute coronary syndrome. Early CTCA facilitated targeted individualisation of these therapies based on the extent of coronary artery disease.PMID:37709109 | DOI:10.1016/j.ahj.2023.09.003
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Kang-Ling Wang Mohammed N Meah Anda Bularga Katherine Oatey Rachel O'Brien Jason E Smith Nick Curzen Attila Kardos Liza Keating Dirk Felmeden Robert F Storey Steve Goodacre Carl Roobottom David E Newby Alasdair J Gray RAPID-CTCA Investigators Source Type: research
AEE alleviates ox-LDL-induced lipid accumulation and inflammation in macrophages
Biomed Pharmacother. 2023 Sep 12;167:115486. doi: 10.1016/j.biopha.2023.115486. Online ahead of print.ABSTRACTAtherosclerosis is a chronic immune inflammatory disease. Aspirin eugenol ester (AEE) is a novel safe and non-toxic compound with many pharmacological effects such as anti-inflammatory, anti-hyperlipidemic and anti-thrombotic action. In order to investigate the effect of AEE on the inhibition of aortic lipid plaque formation and macrophage-derived foam cell formation induced by oxidized low density lipoprotein (ox-LDL), in vivo atherosclerosis model by feeding ApoE-/- mice with a high-fat diet and foam cells format...
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Ya-Xian Liu Xi-Wang Liu Ya-Jun Yang Shi-Hong Li Li-Xia Bai Wen-Bo Ge Xiao Xu Cun Li Jian-Yong Li Zhe Qin Source Type: research
Plasma protein signatures for high on-treatment platelet reactivity to aspirin and clopidogrel in peripheral artery disease
CONCLUSIONS: A plasma protein signature, including eight targets involved in proatherogenic dysfunction of blood cell-vasculature interaction, coagulation and cell death, is associated with HTPR (aspirin and/or clopidogrel) in PAD. This may serve as important systems-based determinants of poor platelet responsiveness to aspirin and/or clopidogrel in PAD and other cardiovascular diseases and may contribute to identify novel treatment strategies.PMID:37708596 | DOI:10.1016/j.thromres.2023.08.017
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: G Baidildinova A Pallares Robles V Ten Cate B M M Kremers S Heitmeier H Ten Cate B M E Mees H M H Spronk P S Wild A J Ten Cate-Hoek K Jurk Source Type: research
Long-term aspirin administration suppresses inflammation in diabetic cystopathy
Aging (Albany NY). 2023 Sep 12;15. doi: 10.18632/aging.205021. Online ahead of print.ABSTRACTDiabetic cystopathy (DCP) is one of the most common and troublesome urologic complications of diabetes mellitus, characterized by chronic low-grade inflammatory response. However, the correlation between inflammation and disease progression remains ambiguous and effective drugs interventions remain deficient. Herein, during 12-week study, 48 male Sprague-Dawley rats were randomly assigned to four groups: negative control (NC), NC treated with aspirin (NC+Aspirin), DCP, and DCP treated with aspirin (DCP+Aspirin). Type 1 diabetes mel...
Source: Aging - September 13, 2023 Category: Biomedical Science Authors: Huifang Du Feihong Xu Jingxuan Liu Jiakui Zhang Yinhua Qin Youqian Xu Ning Li Source Type: research
