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Effects of sex hormones on vascular reactivity in boys with hypospadias
CONCLUSION: In healthy boys, testosterone and 17β-estradiol promote a vasoconstrictor phenotype whereas in boys with hypospadias, these sex hormones reduce vasoconstriction, with androgens promoting vasorelaxation. Differences in baseline artery function may therefore be sex hormone independent and the impact of early-life variations in androgen exposure on vascular function needs further study.PMID:37672642 | DOI:10.1210/clinem/dgad525
Source: The Journal of Clinical Endocrinology and Metabolism - September 6, 2023 Category: Endocrinology Authors: Angela K Lucas-Herald Augusto C Montezano Rheure Alves-Lopes Laura Haddow Stuart O'Toole Martyn Flett Boma Lee S Basith Amjad Mairi Steven Jane McNeilly Katriona Brooksbank Rhian M Touyz S Faisal Ahmed Source Type: research

Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo. « Back to Top Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/ It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Maternal genetic intergenerational and transgenerational effects on hormone synthesis in ovarian granulosa cells of offspring exposed to cadmium during pregnancy
This study aimed to investigate the maternally inherited intergenerational and transgenerational effects of cadmium (Cd) exposure on steroid hormone synthesis in the ovarian granulosa cells (GCs) of offspring rats. F1 rats were obtained by mating adult female Sprague-Dawley rats with healthy adult male rats and were exposed to 0, 0.5, 2.0, and 8.0 mg/kg CdCl2 during pregnancy. The adult female rats (PND 56) were mated with healthy adult male rats to produce F2 and F3 rats. The serum progesterone (Pg) and estradiol (E2) levels of the F2 adult female rats were decreased, while those of F3 rats were significantly increased. M...
Source: Ecotoxicology and Environmental Safety - July 23, 2023 Category: Environmental Health Authors: Lingfeng Luo Jingwen Li Yi Sun Yake Lv Jin Liu Yuchen Li Chenyun Zhang Wenchang Zhang Source Type: research

PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes
In this study, we assessed the role of PARP2 in a Th17-mediated inflammatory skin condition, psoriasis. We found that PARP2 mRNA expression is increased in human psoriatic lesions. Therefore, we studied the functional consequence of decreased PARP2 expression in murine and cellular human models of psoriasis. We observed that the deletion of PARP2 attenuated the imiquimod-induced psoriasis-like dermatitis in mice. Silencing of PARP2 in human keratinocytes prevented their hyperproliferation, maintained their terminal differentiation, and reduced their production of inflammatory mediators after treatment with psoriasis-mimick...
Source: Molecular Medicine - June 23, 2023 Category: Molecular Biology Authors: D óra Antal Ágnes Pór Ilona Kov ács Katalin Dull Szil árd Póliska Gyula Ujlaki M áté Ágoston Demény Attila G ábor Szöllősi Borb ála Kiss Andrea Szegedi P éter Bai Magdolna Sz ántó Source Type: research

Study on the mechanism of estrogen regulating endometrial fibrosis after mechanical injury via miR-21-5p/PPAR α/FAO axis
CONCLUSION: In brief, the above findings revealed that the miR-21-5p/PPARα signal axis played an important role in the fibrosis of endometrial mechanical injury and suggested that estrogen might be a promising agent for its progression.PMID:37078352 | DOI:10.2174/1566524023666230420085743
Source: Current Molecular Medicine - April 20, 2023 Category: Molecular Biology Authors: Shuning Ding Yunyun Hu Peiyu Mao Qiu Lin Zhitao Yao Source Type: research

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