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Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo. « Back to Top Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/ It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Comparison of Three Ovulation Induction Therapies for Patients With Polycystic Ovary Syndrome and Infertility
This article is protected by copyright. All rights reserved.PMID:37493193 | DOI:10.1002/jcph.2318
Source: The Journal of Clinical Pharmacology - July 26, 2023 Category: Drugs & Pharmacology Authors: Ting-Ting Xia Ke-Fei Zeng Qing-Mei Peng Source Type: research

Fabrication of 1-octane sulphonic acid modified nanoporous graphene with tuned hydrophilicity for decontamination of industrial wastewater from organic and inorganic contaminants
RSC Adv. 2023 Jul 20;13(32):21926-21944. doi: 10.1039/d3ra02602g. eCollection 2023 Jul 19.ABSTRACTThis research work is based on the fabrication of a graphene oxide-based composite (GOBC) to remove the maximum number of contaminants from different industrial effluents. The GO was first intercalated with 1-octanesulphonic acid sodium salt and subjected to microwave irradiation to produce GOBC. Fixed-bed column tests and Jar-tests were performed for removal of the most harmful endocrine disrupting compounds (EDCs) such as bisphenol A, bisphenol S, endosulphan, beta-estradiol, dyes (methylene blue and violate) and toxic metal...
Source: Adv Data - July 24, 2023 Category: Epidemiology Authors: Shahbaz Ali Mallah Huma Shaikh Najma Memon Sehrish Qazi Source Type: research

Ovarian morphology and follicular dynamics associated with ovarian aging in Bos indicus beef cows
In conclusion, although cows had increased ovarian volume and decreased follicular population as they age, the follicular growth pattern and corpus luteum functionality appear to be unaffected by age.PMID:37353462 | DOI:10.1016/j.anireprosci.2023.107279
Source: Animal Reproduction Science - June 23, 2023 Category: Zoology Authors: Rafael H Alvarez Keila M R Duarte Jo ão B P Carvalho Cec ília C Rocha Gilmar A A Junior Eduardo Trevisol Alfredo J F Melo Guilherme Pugliesi Source Type: research

Response of the hen ovary to eCG treatment: Insight into morphology and expression of genes related to steroidogenesis and vitellogenesis
Anim Reprod Sci. 2023 May 3;252:107250. doi: 10.1016/j.anireprosci.2023.107250. Online ahead of print.ABSTRACTThe present study aimed to examine the effect of equine chorionic gonadotropin (eCG) treatment on the chicken ovarian folliculogenesis and steroidogenesis. The expression of vitellogenesis-related genes in the liver was also investigated. Laying hens were injected with 75 I.U./kg of body weight/0.2 mL of eCG, once a day for 7 successive days. On day 7 of the experiment hens, including control hens which were receiving vehicle, were euthanized. The liver and ovarian follicles were harvested. Blood was collected dail...
Source: Animal Reproduction Science - May 5, 2023 Category: Zoology Authors: Anna Hrabia Dominika Wolak Andrzej Sechman Colin G Scanes Source Type: research

Dietary n-3 PUFA augments pre-ovulatory follicle turnover and prolificacy in well-fed ewes
Anim Reprod Sci. 2023 Apr 12;252:107231. doi: 10.1016/j.anireprosci.2023.107231. Online ahead of print.ABSTRACTThe present study evaluated the effect of dietary supplementation with n-3 polyunsaturated fatty acids (PUFA) on preovulatory follicle (POF) turnover, prolificacy, and endocrine and metabolic milieu in Malpura sheep. Fifty cyclic ewes with 3-3.5 body condition scores on a five-point scale were allocated equally to two groups (n = 25) following estrus synchronization and were supplemented with 0.6 mL/kg body weight of n-3 PUFA-rich fish oil (FO) or palm oil (PO) as control, for 60 d following an acclimatization per...
Source: Animal Reproduction Science - April 22, 2023 Category: Zoology Authors: Ajit Singh Mahla Suresh Kumar Bunkar Babu Lal Kumawat Vijay Kumar Saxena Sellappan Selvaraju Randhir Singh Bhatt Raghvendar Singh Arun Kumar Source Type: research

Diosgenin reduces bone loss through the regulation of gut microbiota in ovariectomized rats
This study aimed to investigate the effects of DIO on the gut microbiota (GM) of ovariectomized (OVX) osteoporotic rats. Female Sprague-Dawley rats were randomly divided into sham operation (sham + vehicle group) or ovariectomy. For 12 weeks, OVX rats were treated using a vehicle (OVX + vehicle group) and DIO (OVX + DIO group). Subsequently, ELISA was conducted to determine serum estradiol levels, micro-CT scanning was performed to evaluate bone quality, and feces were collected for metagenomics sequencing to examine the structure and function of GM. Raw reads were filtered to remove chimera sequences. Operational taxonomi...
Source: Gene - March 31, 2023 Category: Genetics & Stem Cells Authors: Changheng Song Yujie Ma Yuhan Wang Pei Li Yanjing Chen Haixia Liu Zhiguo Zhang Source Type: research

Effects of resistance training on bone mineral density and resting serum hormones in female collegiate distance runners: a randomized controlled pilot trial
CONCLUSIONS: These findings suggest that 16 weeks of RT in female collegiate distance runners may increase total body BMD.PMID:36884123 | DOI:10.23736/S0022-4707.23.14571-3
Source: Health Physics - March 8, 2023 Category: Physics Authors: Tetsuro Kobayashi Shotaro Seki Inkwan Hwang Source Type: research

18FFDG and 18FFES PET/CT Imaging as a Biomarker for Therapy Effect in Patients with Metastatic ER+ Breast Cancer Undergoing Treatment with Rintodestrant
CONCLUSION: Absence of ER expression on [18F]FES PET is a predictor for no response to rintodestrant. [18F]FES uptake during treatment and at time of progression is useful to monitor the (reversible) effect of therapy and continued mode of action of SERDs.PMID:36735488 | DOI:10.1158/1078-0432.CCR-22-2720
Source: Clinical Cancer Research - February 3, 2023 Category: Cancer & Oncology Authors: Ramsha Iqbal Maqsood Yaqub Husseyin O Bektas Daniela E Oprea-Lager Elisabeth G E de Vries Andor W J M Glaudemans Philippe Aftimos G éraldine Gebhart Andrew P Beelen Robert C Schuit Albert D Windhorst Ronald Boellaard C Willemien Menke-van der Houven van Source Type: research