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Drug: Estradiol

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Total 251 results found since Jan 2013.

Sexual hormones and diabetes: The impact of estradiol in pancreatic β cell
Int Rev Cell Mol Biol. 2021;359:81-138. doi: 10.1016/bs.ircmb.2021.02.004. Epub 2021 Mar 16.ABSTRACTDiabetes is one of the most prevalent metabolic diseases and its incidence is increasing throughout the world. Data from World Health Organization (WHO) point-out that diabetes is a major cause of blindness, kidney failure, heart attacks, stroke and lower limb amputation and estimated 1.6 million deaths were directly caused by it in 2016. Population studies show that the incidence of this disease increases in women after menopause, when the production of estrogen is decreasing in them. Knowing the impact that estrogenic sign...
Source: International Review of Cell and Molecular Biology - April 9, 2021 Category: Cytology Authors: Beatriz Merino Marta Garc ía-Arévalo Source Type: research

Impact of sex differences on thrombin-induced hydrocephalus and white matter injury: the role of neutrophils
ConclusionsICV thrombin injection induced more severe ventricular dilation and white matter damage in female rats compared to males. Estrogen appears to contribute to this difference which may involve greater neutrophil infiltration in females. Understanding sex differences in thrombin-induced brain injury may shed light on future interventions for hemorrhagic stroke.
Source: Fluids and Barriers of the CNS - August 16, 2021 Category: Neuroscience Source Type: research

Hormesis and Endothelial Progenitor Cells
Dose Response. 2022 Feb 23;20(1):15593258211068625. doi: 10.1177/15593258211068625. eCollection 2022 Jan-Mar.ABSTRACTHormetic-biphasic dose response relationships are reported herein for human endothelial progenitor cells involving estradiol, nicotine, the anti-diabetic agent pioglitazone, resveratrol, and progesterone. In general, these studies demonstrate the capacity of these agents to enhance EPC proliferation and angiogenesis functional applications, having a focus on repairing endothelial tissue damage due to acute injury (e.g., stroke), as well as damage from chronic conditions (e.g., atherosclerosis) and normal agi...
Source: Atherosclerosis - February 28, 2022 Category: Cardiology Authors: Edward J Calabrese Source Type: research

Cerebral autoregulation across the menstrual cycle in eumenorrheic women
We describe cerebral autoregulation in eumenorrheic women in the early and late follicular, and mid-luteal phases of the menstrual cycle. The rate of regulation following repeated sit-to-stand maneuvers was correlated with plasma estrogen, with reduced regulation found in women with greater plasma estrogen. No differences in resting hemodynamic variables were observed across the menstrual cycle. These data highlight the individual variation of the cerebrovascular response to forced oscillations in blood pressure in eumenorrheic women. AbstractThere is emerging evidence that ovarian hormones play a significant role in the l...
Source: Physiological Reports - May 7, 2022 Category: Physiology Authors: Stephanie Korad, Toby M ündel, Jui‐Lin Fan, Blake G. Perry Tags: ORIGINAL ARTICLE Source Type: research

Individual Benefits and Risks of Intravaginal Estrogen and Systemic Testosterone in the Management of Women in the Menopause, With a Discussion of Any Associated Risks for Cancer Development
Cancer J. 2022 May-Jun 01;28(3):196-203. doi: 10.1097/PPO.0000000000000598.ABSTRACTSeveral formulations of intravaginal oestrogen are available for the treatment of genitourinary syndrome of menopause (GSM). These are safe and effective treatments for the symptoms of GSM. Licensed doses of intravaginal oestrogen do not elevate systemic estradiol levels above the normal postmenopausal range with long term use and there is no evidence of an increased risk of coronary heart disease, stroke, thromboembolism, colorectal cancer, endometrial cancer, breast cancer or breast cancer recurrence with their use. This should reassure bo...
Source: Cancer Journal - May 20, 2022 Category: Cancer & Oncology Authors: Abbie J Laing Louise Newson James A Simon Source Type: research

Activation of the NLRP3/IL-1 β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats
CONCLUSIONS: To the authors' knowledge, this work represents the first demonstration that, in an aneurysm model under estrogen-deficient conditions, the depletion of ERα and Sirt1 may contribute to activation of the NLRP3/IL-1β/MMP-9 pathway, facilitating the rupture of IAs in the estrogen-deficient rat IA rupture model.PMID:35594890 | DOI:10.3171/2022.4.JNS212945
Source: Journal of Neurosurgery - May 20, 2022 Category: Neurosurgery Authors: Tadashi Yamaguchi Takeshi Miyamoto Eiji Shikata Izumi Yamaguchi Kenji Shimada Kenji Yagi Yoshiteru Tada Masaaki Korai Keiko T Kitazato Yasuhisa Kanematsu Yasushi Takagi Source Type: research

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